{"title":"Pimarane diterpenoids: sources, structures and biological activities.","authors":"Haiqiang Zhang, Meng Li, Ayi Lvha, Shengming Zhang","doi":"10.1080/14786419.2024.2426071","DOIUrl":null,"url":null,"abstract":"<p><p>The pimarane diterpenoids, a widespread class of secondary metabolites, have been found in several dozens of plant species from various families and in organisms from other taxonomic groups. According to the different chiral centres, pimarane diterpenes can be divided into four types, including pimarane, isopimarane, <i>ent</i>-pimarane, and <i>ent</i>-isopimarane. Meanwhile, these compounds possessed many pharmacological activities, such as cytotoxic, anti-inflammatory, and antibacterial activities. Due to their notable structure and biological activities these substances have attracted interest in recent years. A comprehensive account of the structural diversity (368 structures, 117 references) and biological activities of pimarane diterpenes discovered from 2000 until 2023 is given in this review.</p>","PeriodicalId":18990,"journal":{"name":"Natural Product Research","volume":" ","pages":"1-17"},"PeriodicalIF":1.9000,"publicationDate":"2024-11-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Natural Product Research","FirstCategoryId":"92","ListUrlMain":"https://doi.org/10.1080/14786419.2024.2426071","RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"CHEMISTRY, APPLIED","Score":null,"Total":0}
引用次数: 0
Abstract
The pimarane diterpenoids, a widespread class of secondary metabolites, have been found in several dozens of plant species from various families and in organisms from other taxonomic groups. According to the different chiral centres, pimarane diterpenes can be divided into four types, including pimarane, isopimarane, ent-pimarane, and ent-isopimarane. Meanwhile, these compounds possessed many pharmacological activities, such as cytotoxic, anti-inflammatory, and antibacterial activities. Due to their notable structure and biological activities these substances have attracted interest in recent years. A comprehensive account of the structural diversity (368 structures, 117 references) and biological activities of pimarane diterpenes discovered from 2000 until 2023 is given in this review.
期刊介绍：
The aim of Natural Product Research is to publish important contributions in the field of natural product chemistry. The journal covers all aspects of research in the chemistry and biochemistry of naturally occurring compounds.
The communications include coverage of work on natural substances of land and sea and of plants, microbes and animals. Discussions of structure elucidation, synthesis and experimental biosynthesis of natural products as well as developments of methods in these areas are welcomed in the journal. Finally, research papers in fields on the chemistry-biology boundary, eg. fermentation chemistry, plant tissue culture investigations etc., are accepted into the journal.
Natural Product Research issues will be subtitled either ""Part A - Synthesis and Structure"" or ""Part B - Bioactive Natural Products"". for details on this , see the forthcoming articles section.
All manuscript submissions are subject to initial appraisal by the Editor, and, if found suitable for further consideration, to peer review by independent, anonymous expert referees. All peer review is single blind and submission is online via ScholarOne Manuscripts.
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