The roles of pyroptosis in the pathogenesis of autoimmune diseases

IF 5.2 2区医学 Q1 MEDICINE, RESEARCH & EXPERIMENTAL Life sciences Pub Date : 2024-11-12 DOI:10.1016/j.lfs.2024.123232

Yingqiu Song , Yanhui Peng , Bing Wang , Xinyue Zhou , Yikang Cai , Haiyong Chen , Chenggui Miao

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Abstract

The occurrence of autoimmune diseases is a result of the immune system's immune response against healthy components of the body. Pyroptosis is an innovative form of programmed cell death dependent on inflammatory caspases, leading to the release of cytokines. Excessive pyroptosis can lead to a sustained inflammatory response, which may aggravate the development of autoimmune diseases. In rheumatoid arthritis (RA), tumor necrosis factor (TNF) and NLRP3 enhance pyroptosis, exacerbating the disease. In systemic lupus erythematosus (SLE), the release of nuclear antigen promotes the development of SLE. In multiple sclerosis (MS), elevated active caspase-11 in primary astrocytes induces oligodendrocyte pyroptosis, advancing MS progression. This review outlines the mechanisms of pyroptosis in autoimmune diseases. Meanwhile, we elaborated the possible therapeutic targets from the perspective of pyroptosis. We conclude that pyroptosis is expected to be a therapeutic target for autoimmune diseases.

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热蛋白沉积在自身免疫性疾病发病机制中的作用。

自身免疫性疾病的发生是免疫系统对身体健康成分产生免疫反应的结果。细胞凋亡是一种创新的程序性细胞死亡形式，依赖于炎症性卡巴酶，导致细胞因子的释放。过度的裂解热可导致持续的炎症反应，从而可能加重自身免疫性疾病的发展。在类风湿性关节炎（RA）中，肿瘤坏死因子（TNF）和 NLRP3 会增强化脓作用，从而加重病情。在系统性红斑狼疮（SLE）中，核抗原的释放促进了系统性红斑狼疮的发展。在多发性硬化症（MS）中，原发性星形胶质细胞中活性 Caspase-11 的升高会诱导少突胶质细胞热解，从而推进 MS 的进展。本综述概述了自身免疫性疾病的热解机制。同时，我们从热蛋白沉积的角度阐述了可能的治疗靶点。最后，我们得出结论，热蛋白沉积有望成为自身免疫性疾病的治疗靶点。

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来源期刊

Life sciences 医学-药学

CiteScore

12.20

自引率

1.60%

发文量

841

审稿时长

6 months

期刊介绍： Life Sciences is an international journal publishing articles that emphasize the molecular, cellular, and functional basis of therapy. The journal emphasizes the understanding of mechanism that is relevant to all aspects of human disease and translation to patients. All articles are rigorously reviewed. The Journal favors publication of full-length papers where modern scientific technologies are used to explain molecular, cellular and physiological mechanisms. Articles that merely report observations are rarely accepted. Recommendations from the Declaration of Helsinki or NIH guidelines for care and use of laboratory animals must be adhered to. Articles should be written at a level accessible to readers who are non-specialists in the topic of the article themselves, but who are interested in the research. The Journal welcomes reviews on topics of wide interest to investigators in the life sciences. We particularly encourage submission of brief, focused reviews containing high-quality artwork and require the use of mechanistic summary diagrams.