Two new flavonoid glucosides from Penthorum chinense Pursh.

IF 1.9 3区化学 Q3 CHEMISTRY, APPLIED Natural Product Research Pub Date : 2024-11-09 DOI:10.1080/14786419.2024.2426211

Shengyao Lu, Songfan Jiang, Jingxian Feng, Wansheng Chen, Doudou Huang, Lianna Sun

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Abstract

Two new flavonoids, Alpinetin-7-O-[3''-O-galloyl-4'',6''-hexahydroxy-diphenoyl]-β-D-glucose (1), Pinocembrin-7-O-[4''-O-galloyl]-β-D-glucose (2), and three known compound (3-5) were isolated from Penthorum chinense Pursh (Saxifragaceae). The structures of all compounds were deduced from their comprehensive spectroscopic analysis including IR, HR-ESI-MS,¹H NMR,¹³C NMR, DEPT, COSY, HMBC and HMQC. Molecular docking model was used to test the anti-cholestatic liver activities of the isolated compounds, and compounds 1 and 2 showed higher docking scores (-9.90 and -11.27 kcal/mol, respectively) binding with FXR than 3, 4 and 5 (-8.00, -9.77, -9.10 kcal/mol, respectively), suggesting 1 and 2 exhibited potential anti-cholestatic activities. The present results show that P. chinense is a potential source of 2 new lead compounds that can be utilised to produce therapeutic drugs for liver diseases upon further studies.

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Penthorum chinense Pursh.的两种新黄酮苷。

从 Penthorum chinense Pursh（虎耳草科）中分离出两种新的黄酮类化合物：Alpinetin-7-O-[3''-O-galloyl-4'',6''-hexahydroxy-diphenoyl]-β-D-葡萄糖（1）、Pinocembrin-7-O-[4''-O-galloyl]-β-D-葡萄糖（2）和三种已知化合物（3-5）。所有化合物的结构都是通过综合光谱分析推导出来的，包括红外光谱、HR-ESI-MS、1H NMR、13C NMR、DEPT、COSY、HMBC 和 HMQC。采用分子对接模型检验了分离化合物的抗胆汁淤积性肝炎活性，结果表明，化合物 1 和 2 与 FXR 的对接得分（分别为 -9.90 和 -11.27 kcal/mol）高于 3、4 和 5（分别为 -8.00、-9.77 和 -9.10 kcal/mol），表明 1 和 2 具有潜在的抗胆汁淤积活性。本研究结果表明，金丝桃是两种新先导化合物的潜在来源，经进一步研究，可用于生产治疗肝病的药物。

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来源期刊

Natural Product Research 化学-医药化学

CiteScore

5.10

自引率

9.10%

发文量

605

审稿时长

2.1 months

期刊介绍： The aim of Natural Product Research is to publish important contributions in the field of natural product chemistry. The journal covers all aspects of research in the chemistry and biochemistry of naturally occurring compounds. The communications include coverage of work on natural substances of land and sea and of plants, microbes and animals. Discussions of structure elucidation, synthesis and experimental biosynthesis of natural products as well as developments of methods in these areas are welcomed in the journal. Finally, research papers in fields on the chemistry-biology boundary, eg. fermentation chemistry, plant tissue culture investigations etc., are accepted into the journal. Natural Product Research issues will be subtitled either ""Part A - Synthesis and Structure"" or ""Part B - Bioactive Natural Products"". for details on this , see the forthcoming articles section. All manuscript submissions are subject to initial appraisal by the Editor, and, if found suitable for further consideration, to peer review by independent, anonymous expert referees. All peer review is single blind and submission is online via ScholarOne Manuscripts.