Lycopene-Loaded Emulsions: Chitosan Versus Non-Ionic Surfactants as Stabilizers.

IF 4.2 2区化学 Q2 BIOCHEMISTRY & MOLECULAR BIOLOGY Molecules Pub Date : 2024-11-04 DOI:10.3390/molecules29215209

Sonia Álvarez-García, Lucie Couarraze, María Matos, Gemma Gutiérrez

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Abstract

Lycopene is a natural carotenoid with well-known benefits due to its antioxidant properties, including an anti-inflammatory effect in colorectal cancer and anti-angiogenic effects along with a reduction in the risk of prostate cancer and coronary heart disease. Due to their poor water solubility, photosensitivity and heat sensitivity, their incorporation in cosmetic and food matrices should be through encapsulation systems. In the present work, lycopene-loaded emulsions were prepared using two different types of stabilizers: non-ionic surfactants, testing several ratios of Tween 80 and Span 80, and chitosan, using chitosans of different viscosities and molecular weights. Soybean oil was found to be a suitable candidate for O/W emulsion preparation. Lycopene encapsulation efficiency (EE) of 70-75% and loading capacities of 0.14 mg/g were registered in stable emulsions stabilized either by non-ionic surfactants or acidified chitosans. Therefore, chitosan is a good alternative as a sustainable stabilizer to partially replace traditional synthetic ingredients with a new biodegradable, renewable and biocompatible material which could contribute to reduce the environmental impact as well as the ingestion of synthetic toxic materials by humans, decreasing their risk of suffering from chronic and complex pathologies, among which several types of cancer stand out.

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番茄红素乳液：壳聚糖与作为稳定剂的非离子表面活性剂的对比。

番茄红素是一种天然类胡萝卜素，具有众所周知的抗氧化功效，包括对结直肠癌的抗炎作用、抗血管生成作用以及降低前列腺癌和冠心病的风险。由于番茄红素的水溶性差、光敏性和热敏性，因此应通过封装系统将其添加到化妆品和食品基质中。在本研究中，我们使用两种不同类型的稳定剂制备了番茄红素乳液：一种是非离子表面活性剂，测试了 Tween 80 和 Span 80 的不同比例；另一种是壳聚糖，使用了不同粘度和分子量的壳聚糖。结果发现，大豆油是一种适合用于制备 O/W 型乳液的候选物质。在由非离子表面活性剂或酸化壳聚糖稳定的稳定乳液中，番茄红素的封装效率（EE）为 70-75%，负载能力为 0.14 mg/g。因此，壳聚糖是一种很好的可持续稳定剂替代品，它可以用一种可生物降解、可再生和生物兼容的新材料部分取代传统的合成成分，从而有助于减少对环境的影响以及人类对合成有毒材料的摄入，降低他们患慢性和复杂病症的风险，其中包括几种癌症。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Molecules 化学-有机化学

CiteScore

7.40

自引率

8.70%

发文量

7524

审稿时长

1.4 months

期刊介绍： Molecules (ISSN 1420-3049, CODEN: MOLEFW) is an open access journal of synthetic organic chemistry and natural product chemistry. All articles are peer-reviewed and published continously upon acceptance. Molecules is published by MDPI, Basel, Switzerland. Our aim is to encourage chemists to publish as much as possible their experimental detail, particularly synthetic procedures and characterization information. There is no restriction on the length of the experimental section. In addition, availability of compound samples is published and considered as important information. Authors are encouraged to register or deposit their chemical samples through the non-profit international organization Molecular Diversity Preservation International (MDPI). Molecules has been launched in 1996 to preserve and exploit molecular diversity of both, chemical information and chemical substances.