Coffee and Risk of Pancreatic Cancer: Insights from Two-Sample and Multivariable Mendelian Randomization Analyses.

IF 4.8 2区医学 Q1 NUTRITION & DIETETICS Nutrients Pub Date : 2024-10-31 DOI:10.3390/nu16213723

Yin Lu, Peng Wang, Haiyan Liu, Tiandong Li, Han Wang, Donglin Jiang, Ling Liu, Hua Ye

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Abstract

Background: The association between coffee and pancreatic cancer risk has reported inconsistent results. Therefore, a Mendelian randomization (MR) study was undertaken to investigate the association between coffee and pancreatic cancer from a genetic perspective.

Methods: In East Asian and European populations, independent genetic variants strongly associated with coffee were chosen as instrumental variables (IVs) from relevant genome-wide association studies (GWASs). GWAS data for pancreatic cancer were obtained from the JENGER (Japanese Encyclopedia of Genetic Associations by Riken) project and GWAS catalog database. Two-sample (TSMR) and multivariable Mendelian randomization (MVMR) analyses were conducted to investigate the genetically predicted causal relationship between coffee consumption and pancreatic cancer. A fixed-effect meta-analysis was employed to aggregate estimates from the two populations to reveal the overall association.

Results: Both in East Asian and European populations, an increase in coffee intake of a cup per day was not associated with pancreatic cancer risk, regardless of coffee type (including caffeine drinks, instant coffee, decaffeinated coffee, ground coffee, etc.). The results aligned with the findings of the meta-analysis (OR = 1.100, 95%CI = 0.862-1.403, p = 0.450). Also, for coffee intake with positive results in the TSMR analysis (OR = 1.739, 95%CI 1.104-2.739, p = 0.017), consistent negative results were observed after adjusting for potential confounders (smoking traits, drinking, type 2 diabetes, body mass index) in the MVMR analyses.

Conclusions: This study found no genetically predicted causal relationship between coffee consumption and pancreatic cancer risk.

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咖啡与胰腺癌风险：双样本和多变量孟德尔随机分析的启示。

背景：关于咖啡与胰腺癌风险之间的关系，报道的结果并不一致。因此，我们开展了一项孟德尔随机化（MR）研究，从遗传学角度探讨咖啡与胰腺癌之间的关联：方法：在东亚和欧洲人群中，从相关的全基因组关联研究（GWAS）中选择与咖啡密切相关的独立遗传变异作为工具变量（IV）。胰腺癌的 GWAS 数据来自 JENGER（日本理研遗传关联百科全书）项目和 GWAS 目录数据库。通过双样本（TSMR）和多变量孟德尔随机化（MVMR）分析，研究了饮用咖啡与胰腺癌之间的遗传预测因果关系。采用固定效应荟萃分析将两个人群的估计值进行汇总，以揭示整体关联：结果：在东亚和欧洲人群中，无论咖啡类型（包括咖啡因饮料、速溶咖啡、无咖啡因咖啡、研磨咖啡等）如何，每天增加一杯咖啡的摄入量与胰腺癌风险无关。结果与荟萃分析的结果一致（OR = 1.100，95%CI = 0.862-1.403，p = 0.450）。此外，咖啡摄入量在TSMR分析中呈阳性结果（OR = 1.739，95%CI = 1.104-2.739，p = 0.017），在MVMR分析中调整了潜在的混杂因素（吸烟特征、饮酒、2型糖尿病、体重指数）后，也观察到了一致的阴性结果：本研究发现，饮用咖啡与胰腺癌风险之间没有遗传学预测的因果关系。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Nutrients NUTRITION & DIETETICS-

CiteScore

9.20

自引率

15.30%

发文量

4599

审稿时长

16.74 days

期刊介绍： Nutrients (ISSN 2072-6643) is an international, peer-reviewed open access advanced forum for studies related to Human Nutrition. It publishes reviews, regular research papers and short communications. Our aim is to encourage scientists to publish their experimental and theoretical results in as much detail as possible. There is no restriction on the length of the papers. The full experimental details must be provided so that the results can be reproduced.