Effects of Bisphenol A on the Risk of Developing Obesity.

IF 4.8 2区医学 Q1 NUTRITION & DIETETICS Nutrients Pub Date : 2024-10-31 DOI:10.3390/nu16213740

Mónica García García, Yolanda Picó, María Morales-Suárez-Varela

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Abstract

Background: Every year the global incidence of obesity increases considerably and among the factors that favor it is bisphenol A (BPA), an endocrine disruptor widely used in plastics and omnipresent in many everyday objects.

Methods: A total of 19 studies published between 2018 and 2023 that addressed the relationship between BPA exposure and obesity were included in this review in order to better understand its behavior and mechanisms of action.

Results: The studies reviewed conclude that BPA is an obesogen that alters the function of hormonal receptors, promotes metabolic syndrome, affects certain genes, etc., leading to a greater risk of developing obesity. With important emphasis on the ability to cause epigenetic changes, thus transmitting the effects to offspring when exposure has occurred during critical stages of development such as during gestation or the perinatal period.

Conclusions: There is sufficient evidence to show that BPA is a risk factor in the development of obesity. Even so, further research is necessary to exhaustively understand the causal relationship between the two in order to develop prevention measures and avoid possible future adverse effects.

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双酚 A 对肥胖症发病风险的影响。

背景：全球肥胖症的发病率每年都在大幅增加，而双酚A（BPA）是导致肥胖的因素之一，双酚A是一种内分泌干扰物，广泛应用于塑料中，在许多日常用品中无处不在：为了更好地了解双酚 A 的行为和作用机制，本综述共纳入了 2018 年至 2023 年间发表的 19 项关于双酚 A 暴露与肥胖关系的研究：综述的研究得出结论：双酚A是一种肥胖原，会改变激素受体的功能，促进代谢综合征，影响某些基因等，导致肥胖风险增加。结论：有足够的证据表明，在妊娠期或围产期等发育的关键阶段接触溴化联苯醚，会引起表观遗传学的变化，从而将影响传给后代：有足够的证据表明，双酚 A 是导致肥胖的一个危险因素。尽管如此，仍有必要开展进一步的研究，以全面了解两者之间的因果关系，从而制定预防措施，避免未来可能出现的不利影响。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Nutrients NUTRITION & DIETETICS-

CiteScore

9.20

自引率

15.30%

发文量

4599

审稿时长

16.74 days

期刊介绍： Nutrients (ISSN 2072-6643) is an international, peer-reviewed open access advanced forum for studies related to Human Nutrition. It publishes reviews, regular research papers and short communications. Our aim is to encourage scientists to publish their experimental and theoretical results in as much detail as possible. There is no restriction on the length of the papers. The full experimental details must be provided so that the results can be reproduced.