Effect of Cooling Capsaicin Application Site on Reducing Burning Sensation in Neuropathic Pain Patients: A Randomized Controlled Trial.

IF 1.6 4区医学 Q2 NURSING Pain Management Nursing Pub Date : 2024-11-11 DOI:10.1016/j.pmn.2024.09.001

Natacha Tailliez, Lucie Planche, Agnès Dorion, Nicolas Kacki, Jérôme Dimet, Yves-Marie Pluchon

{"title":"Effect of Cooling Capsaicin Application Site on Reducing Burning Sensation in Neuropathic Pain Patients: A Randomized Controlled Trial.","authors":"Natacha Tailliez, Lucie Planche, Agnès Dorion, Nicolas Kacki, Jérôme Dimet, Yves-Marie Pluchon","doi":"10.1016/j.pmn.2024.09.001","DOIUrl":null,"url":null,"abstract":"Purpose: Treatment of localized neuropathic pain continues to represent an unmet need. The primary objective of the present study was to evaluate the efficacy of cryotherapy to reduce the burning pain induced by capsaicin (8%) patches (QUTENZA) in a neuropathic pain cohort. We also investigated subsequent neuropathic pain during an 8-week follow-up.Design: The present work resulted from a prospective, randomized, two-center, open-label, interventional French trial.Methods: This study aimed to investigate the effects of cooling of the application area of QUTENZA patches. Visual analog scale (VAS) scores were measured 30 and 60 minutes after patch application. Weekly neuropathic VAS scores were then collated for 2 months. Ninety-nine patients were included and randomized into a cryotherapy group (n = 50 [80% women], median age = 51 years old) and a no cryotherapy group (n = 49 [69% women], median age = 48 years old).Results: Cooling at the application site of the patch resulted in a reduction by 3.20 in burning pain VAS score at 60 minutes, with no cooling VAS 6.99 (95% CI [6.2, 7.77]) versus 3.78 (95% CI [3, 4.56]) for cryotherapy. Neuropathic VAS pain scores over the follow-up period were not statistically different.Conclusions: Cryotherapy at the application site significantly reduced the burning pain induced by capsaicin patches but had no effect on neuropathic pain for the 8 weeks following application.Clinical implications: The use of cooling during capsaicin patch application, by ameliorating the therapeutic alliance, improves the clinical management of neuropathic pain. © 20XX by the American Society for Pain Management Nursing.","PeriodicalId":19959,"journal":{"name":"Pain Management Nursing","volume":" ","pages":""},"PeriodicalIF":1.6000,"publicationDate":"2024-11-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Pain Management Nursing","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1016/j.pmn.2024.09.001","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"NURSING","Score":null,"Total":0}

引用次数: 0

Abstract

Purpose: Treatment of localized neuropathic pain continues to represent an unmet need. The primary objective of the present study was to evaluate the efficacy of cryotherapy to reduce the burning pain induced by capsaicin (8%) patches (QUTENZA) in a neuropathic pain cohort. We also investigated subsequent neuropathic pain during an 8-week follow-up.

Design: The present work resulted from a prospective, randomized, two-center, open-label, interventional French trial.

Methods: This study aimed to investigate the effects of cooling of the application area of QUTENZA patches. Visual analog scale (VAS) scores were measured 30 and 60 minutes after patch application. Weekly neuropathic VAS scores were then collated for 2 months. Ninety-nine patients were included and randomized into a cryotherapy group (n = 50 [80% women], median age = 51 years old) and a no cryotherapy group (n = 49 [69% women], median age = 48 years old).

Results: Cooling at the application site of the patch resulted in a reduction by 3.20 in burning pain VAS score at 60 minutes, with no cooling VAS 6.99 (95% CI [6.2, 7.77]) versus 3.78 (95% CI [3, 4.56]) for cryotherapy. Neuropathic VAS pain scores over the follow-up period were not statistically different.

Conclusions: Cryotherapy at the application site significantly reduced the burning pain induced by capsaicin patches but had no effect on neuropathic pain for the 8 weeks following application.

Clinical implications: The use of cooling during capsaicin patch application, by ameliorating the therapeutic alliance, improves the clinical management of neuropathic pain. © 20XX by the American Society for Pain Management Nursing.

查看原文

微信好友朋友圈 QQ好友复制链接

本刊更多论文

冷却辣椒素应用部位对减轻神经病理性疼痛患者灼烧感的影响：随机对照试验

目的：局部神经病理性疼痛的治疗仍是一项尚未满足的需求。本研究的主要目的是评估冷冻疗法对减轻神经性疼痛人群中由辣椒素（8%）贴片（QUTENZA）引起的灼痛的疗效。我们还调查了 8 周随访期间神经病理性疼痛的后续情况：本研究是法国一项前瞻性、随机、双中心、开放标签、干预性试验的结果：本研究旨在探讨冷却 QUTENZA 贴片应用区域的效果。贴敷 30 分钟和 60 分钟后测量视觉模拟量表（VAS）评分。然后在 2 个月内每周整理一次神经病理性 VAS 评分。99 名患者被随机分为冷冻治疗组（n = 50 [80% 女性]，中位年龄 = 51 岁）和无冷冻治疗组（n = 49 [69% 女性]，中位年龄 = 48 岁）：贴片贴敷部位冷却后，60 分钟后灼烧痛 VAS 评分降低了 3.20，不冷却 VAS 评分为 6.99（95% CI [6.2，7.77]），而冷冻疗法 VAS 评分为 3.78（95% CI [3，4.56]）。随访期间的神经病理性 VAS 疼痛评分没有统计学差异：结论：在贴敷部位进行冷冻治疗可明显减轻辣椒素贴片引起的灼痛，但在贴敷后的 8 周内对神经性疼痛没有影响：临床意义：在贴敷辣椒素贴片时使用冷冻疗法可改善治疗联盟，从而改善神经性疼痛的临床治疗。©20XX年美国疼痛管理护理学会。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文去求助

来源期刊

Pain Management Nursing 医学-护理

CiteScore

3.00

自引率

5.90%

发文量

187

审稿时长

>12 weeks

期刊介绍： This peer-reviewed journal offers a unique focus on the realm of pain management as it applies to nursing. Original and review articles from experts in the field offer key insights in the areas of clinical practice, advocacy, education, administration, and research. Additional features include practice guidelines and pharmacology updates.