Dual-Template Molecularly Imprinted Polymers for Dispersive Solid-Phase Extraction Combined with High Performance Liquid Chromatography for the Determination of Sulfonamide Antibiotics in Environmental Water Samples.

IF 4.7 3区工程技术 Q1 POLYMER SCIENCE Polymers Pub Date : 2024-11-01 DOI:10.3390/polym16213095

Yuhao Wen, Mingyang Hou, Xingkai Hao, Dani Sun, Hao Zhang, Farooq Saqib, Wenhui Lu, Huitao Liu, Lingxin Chen, Jinhua Li

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Abstract

In this study, we designed a molecularly imprinted polymers-dispersive solid-phase extraction-high-performance liquid chromatography (MIPs-DSPE-HPLC) method, as a simple and efficient platform for the sensitive detection of two sulfonamide antibiotics (SAs) of sulfamethoxine (SMM) and sulfamethoxazole (SMZ) in environmental water samples. Using SMM and SMZ as templates, methacrylic acid as the functional monomer, ethylene glycol dimethacrylate as the crosslinking agent, and azodiisobutyronitrile as the catalyst, the dual-template molecularly imprinted polymers (dt-MIPs) were successfully synthesized via surface imprinting technology and multi-template imprinting strategy. The adsorption properties of the prepared MIPs were characterized, and the adsorption capacities of MIPs towards SMZ and SMM were 27.35 mg/g and 30.92 mg/g, respectively. The detection limits of the method in three environmental water samples were in the range of 0.23-1.74 μg/L, and the recoveries were between 82.7 and 110.3%, with relative standard deviations less than 5.93%. The construction process of this MIPs-DSPE-HPLC method is straightforward, exhibits high sensitivity and selectivity, and thus provides a versatile method for the quantification of SAs in complex matrices.

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用于分散固相萃取的双模板分子印迹聚合物结合高效液相色谱法测定环境水样中的磺胺类抗生素。

本研究设计了一种分子印迹聚合物-分散固相萃取-高效液相色谱（MIPs-DSPE-HPLC）方法，作为灵敏检测环境水样中磺胺类抗生素（SAs）--磺胺甲噁嗪（SMM）和磺胺甲噁唑（SMZ）--的简单高效平台。以SMM和SMZ为模板，甲基丙烯酸为功能单体，乙二醇二甲基丙烯酸酯为交联剂，偶氮二异丁腈为催化剂，通过表面印迹技术和多模板印迹策略成功合成了双模板分子印迹聚合物（dt-MIPs）。对所制备的分子印迹聚合物的吸附性能进行了表征，其对SMZ和SMM的吸附量分别为27.35 mg/g和30.92 mg/g。该方法在3种环境水样中的检出限为0.23～1.74 μg/L，回收率为82.7%～110.3%，相对标准偏差小于5.93%。该MIPs-DSPE-HPLC方法的构建过程简便、灵敏度高、选择性好,为复杂基质中SAs的定量提供了一种通用的方法。

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来源期刊

Polymers POLYMER SCIENCE-

CiteScore

8.00

自引率

16.00%

发文量

4697

审稿时长

1.3 months

期刊介绍： Polymers (ISSN 2073-4360) is an international, open access journal of polymer science. It publishes research papers, short communications and review papers. Our aim is to encourage scientists to publish their experimental and theoretical results in as much detail as possible. Therefore, there is no restriction on the length of the papers. The full experimental details must be provided so that the results can be reproduced. Polymers provides an interdisciplinary forum for publishing papers which advance the fields of (i) polymerization methods, (ii) theory, simulation, and modeling, (iii) understanding of new physical phenomena, (iv) advances in characterization techniques, and (v) harnessing of self-assembly and biological strategies for producing complex multifunctional structures.