Polymers最新文献

Natural polysaccharides can serve as carriers of genes owing to their intrinsic biocompatibility, biodegradability, and low toxicity. Additionally, they can be easily chemically modified, e.g., through grafting, leading to hybrid synthetic-biological copolymers with additional functionalities. In this work we report on the electrostatic interaction between a chitosan-g-poly(N-isopropylacrylamide) (Chit-g-PNIPAM) copolymer and DNA macromolecules of different lengths (i.e., 50 and 2000 bp), towards the construction of polyplexes that can serve as potential gene delivery systems. At the basic science level, the work aims to elucidate the effects of DNA length on the structural and physicochemical properties of the thermoresponsive hybrid macromolecular assemblies. The protonated amino groups on the chitosan backbone enable electrostatic binding with the anionic phosphate groups of the DNA molecules, while the PNIPAM side chains are expected to impart thermoresponsive properties to the formed polyplexes. Different amino to phosphate group (N/P) mixing ratios were examined, aiming to produce stable dispersions. The physicochemical properties of the resulting polyplexes were investigated by dynamic and electrophoretic light scattering (DLS and ELS), while their morphology was studied by scanning-transmission electron microscopy (STEM). Moreover, their response to changes in temperature and ionic strength, as well as their stability against biological media, was also examined. Finally, the binding affinity of the copolymer towards DNA was evaluated through fluorescence spectroscopy, using ethidium bromide quenching assays, while infrared spectroscopy was used to investigate the structure of the incorporated DNA chains.

We introduce a novel concept in nucleic acid delivery based on the use of mixed polymeric micelles (MPMs) as platforms for the preparation of micelleplexes with DNA. MPMs were prepared by the co-assembly of a cationic copolymer, poly(1-(4-methylpiperazin-1-yl)-propenone)-b-poly(d,l-lactide), and nonionic poly(ethylene oxide)-b-poly(propylene oxide)-b-poly(ethylene oxide) block copolymers. We hypothesize that by introducing nonionic entities incorporated into the mixed co-assembled structures, the mode and strength of DNA binding and DNA accessibility and release could be modulated. The systems were characterized in terms of size, surface potential, buffering capacity, and binding ability to investigate the influence of composition, in particular, the poly(ethylene oxide) chain length on the properties and structure of the MPMs. Endo-lysosomal conditions were simulated to follow the changes in fundamental parameters and behavior of the micelleplexes. The results were interpreted as reflecting the specific structure and composition of the corona and localization of DNA in the corona, predetermined by the poly(ethylene oxide) chain length. A favorable effect of the introduction of the nonionic block copolymer component in the MPMs and micelleplexes thereof was the enhancement of biocompatibility. The slight reduction of the transfection efficiency of the MPM-based micelleplexes compared to that of the single-component polymer micelles was attributed to the premature release of DNA from the MPM-based micelleplexes in the endo-lysosomal compartments.

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Incremental sheet forming has emerged as an excellent alternative to other material forming procedures, incrementally deforming flat metal sheets into complex three-dimensional profiles. The main characteristics of this process are its versatility and cost-effectiveness; additionally, it allows for greater formability compared to conventional sheet forming processes. Recently, its application has been extended to polymers and composites. The following review aims to present the current state of the art in the incremental sheet forming of polycarbonate, an outstanding engineering plastic, beginning with initial studies on the feasibility of this process for polymers. Attention is given to the advantages, drawbacks, and main applications of incrementally formed polycarbonate sheets, as well as the influence of process parameters and toolpath strategies on features such as formability, forming forces, deformation and failure mechanisms, geometric accuracy, surface quality, etc. Additionally, new hybrid forming methods for process optimisation are presented. Finally, a discussion is provided on the technical challenges and future research directions for incremental sheet forming of polycarbonate and, more generally, thermoplastics. Thus, this review aims to offer an extensive overview of the incremental forming of polycarbonate sheets, useful to both academic and industrial researchers working on this topic.

Biobased polymers such as polylactic acid (PLA) and polybutylene succinate (PBS) break down naturally under certain environmental conditions. The efficiency of degradation can be linked directly to fiber surface properties, which influence polymer accessibility. Here, the degradation of PLA and PBS fibers with six different cross-sections was investigated. The fibers were aged by hydrolysis and UV exposure in an accelerated weathering test, followed by an ISO 20200 laboratory-scale disintegration test with non-aged fibers as controls. The polymers were analyzed by differential scanning calorimetry, Fourier transform infrared spectroscopy, and gel permeation chromatography, comparing the polymer granulate, virgin fibers, and UV-exposed fibers. It was found that the molecular mass and crystallinity of PBS changed more than PLA during spinning. Several PLA samples were completely degraded, whereas all the PBS samples remained intact. Furthermore, surface openings appeared on the PLA fibers during weathering, suggesting greater sensitivity to UV exposure and hydrolysis than PBS. A clear correlation between the fiber surface area and the degradation rate was observed for all samples, but the correlation was positive for PLA and negative for PBS. The slower degradation of PBS fibers with a larger surface area may reflect the ability of PBS to preserve itself by further crystallization during degradation processes at temperatures higher than the glass transition point. The data clearly show that the analysis of single degradation mechanisms is insufficient to predict the behavior of material under real-world conditions, where different degradation mechanisms may work in parallel or consecutively, and may show interdependencies.

Accurate energy consumption prediction in the injection molding process is crucial for optimizing energy efficiency in polymer processing. Traditional parameter optimization methods face challenges in achieving optimal energy prediction due to complex energy transmission. In this study, a data-driven approach based on the Rolling Learning Informer model is proposed to enhance the accuracy and adaptability of energy consumption forecasting. The Informer model addresses the limitations of long-sequence prediction with sparse attention mechanisms, self-attention distillation, and generative decoder techniques. Rolling learning prediction is incorporated to enable continuous updating of the model to reflect new data trends. Experimental results demonstrate that the RL-Informer model achieves a normalized root mean square error of 0.1301, a root mean square error of 0.0758, a mean absolute error of 0.0562, and a coefficient of determination of 0.9831 in energy consumption forecasting, outperforming other counterpart models like Gated Recurrent Unit, Temporal Convolutional Networks, Long Short-Term Memory, and two variants of the pure Informer models without Rolling Learning. It is of great potential for practical engineering applications.

In the last decade, the task of developing environmentally friendly and cost-effective methods for obtaining stable superhydrophobic coatings has become topical. In this study, we examined the effect of the concentrations of filler and polymer binder on the hydrophobic properties and surface roughness of composite coatings made from organic-aqueous compositions based on hexyl methacrylate (HMA) and glycidyl methacrylate (GMA) copolymers. Silicon dioxide nanoparticles were used as a filler. A single-stage "all-in-one" aerosol application method was used to form the coatings without additional intermediate steps for attaching the adhesive layer or texturing the substrate surface, as well as pre-modification of the surface of filler nanoparticles. As the ratio of the mass fraction of polymer binder (Wn) to filler (Wp) increases, the coatings show the lowest roll-off angles among the whole range of samples studied. Coatings with an optimal mass fraction ratio (Wn/Wp = 1.2 ÷ 1.6) of the filler to polymer binder maintained superhydrophobic properties for 24 h in contact with a drop of water in a chamber saturated with water vapor and exhibited roll-off angles of 6.1° ± 1°.

This study investigated the performance of recycled waste fishing net sheets (WSs) as a sustainable strengthening material for reinforced concrete (RC) slabs. The primary challenge addressed is the debonding failure caused by the low bond strength at the WS-to-concrete interface. To analyze this, two full-scale RC slabs-one with and one without strengthening-were cast and tested under a four-point bending setup. Finite element (FE) models incorporating existing bond-slip laws were developed using the ABAQUS software to simulate the strengthened slab's behavior. A sensitivity analysis was performed to assess the impact of bond-slip parameters on the failure mechanism. Experimental results indicated that the WS-strengthened slab enhanced the RC slab capacities by 15% in yield load and 13% in initial stiffness. Furthermore, the maximum shear stress of 0.5τ_max or interfacial fracture energy of 0.2G_f, compared to values proposed by Monti et al., enabled the simulation of the global response observed in the experiment.

In this study, we designed a molecularly imprinted polymers-dispersive solid-phase extraction-high-performance liquid chromatography (MIPs-DSPE-HPLC) method, as a simple and efficient platform for the sensitive detection of two sulfonamide antibiotics (SAs) of sulfamethoxine (SMM) and sulfamethoxazole (SMZ) in environmental water samples. Using SMM and SMZ as templates, methacrylic acid as the functional monomer, ethylene glycol dimethacrylate as the crosslinking agent, and azodiisobutyronitrile as the catalyst, the dual-template molecularly imprinted polymers (dt-MIPs) were successfully synthesized via surface imprinting technology and multi-template imprinting strategy. The adsorption properties of the prepared MIPs were characterized, and the adsorption capacities of MIPs towards SMZ and SMM were 27.35 mg/g and 30.92 mg/g, respectively. The detection limits of the method in three environmental water samples were in the range of 0.23-1.74 μg/L, and the recoveries were between 82.7 and 110.3%, with relative standard deviations less than 5.93%. The construction process of this MIPs-DSPE-HPLC method is straightforward, exhibits high sensitivity and selectivity, and thus provides a versatile method for the quantification of SAs in complex matrices.

Compressive testing of specimens taken from relatively thin composite plates is difficult, especially due to the occurrence of buckling. To prevent buckling, the central portion of the specimens used for the compression test has smaller dimensions, and the specimens can be guided along their entire length. For these reasons, optical methods, such as digital image correlation (DIC), cannot be used for the compression test and strain rosettes cannot be glued onto the samples to determine Poisson's ratio. In this study, compression tests of a glass fiber-reinforced polymer (GFRP) were conducted using both the ASTM D695 (Boeing version) and a newly proposed method. The new method involves using special specimens that allow T-type rosettes to be bonded to determine Poisson's ratio, whose value of 0.14 was thus determined. SEM images of the failure surfaces were presented and interpreted. A finite element analysis (FEA) of the specimens tested in compression is also presented. The first analyzed case considers the homogeneous and orthotropic composite, loaded with a uniformly distributed force. The normal stress in the central section of the specimen, determined with FEA, has an error of 6.52% compared to that determined experimentally. Additionally, the strain in the center of the strain gauge, determined with FEA, has an error of 4.76% compared to the measured one. In the second case studied with FEA, the sample is loaded with a quasi-concentrated force, which can move in the direction of the symmetry axes of the cross-section, to study the effect of the eccentricity of the compression force on the state of stress. It was shown that the eccentricity of the force has a great influence: the stress distribution in the section of the specimen becomes strongly non-uniform. For a force eccentricity of 0.4 mm in the direction of the OX axis, the minimum stress decreases by 53.7%, and the maximum stress increases by 55.4%. In order to analyze the influence of some manufacturing defects, two other cases were analyzed by FEA, in which it was assumed that the thicknesses of the outer resin layers were modified, making them asymmetrical. For this final FEA, the specimen was considered to be composed of laminates. These results demonstrate the special attention that must be paid to the centric application of force in compression testing.