{"title":"Profile of Cytokines and T Cell Subsets Transcription Factors in Cerebrospinal Fluid of Patients with Viral Encephalitis.","authors":"Khadija Tebibi, Rafika Ben Laamari, Zakaria Saied, Olfa Maghrebi, Henda Touzi, Zina Meddeb, Samia Ben Sassi, Henda Triki, Meriam Belghith, Dorra Rezig","doi":"10.1089/vim.2024.0058","DOIUrl":null,"url":null,"abstract":"<p><p>This study investigates the demographic, clinical characteristics, virological profiles, and immunological responses of patients with viral encephalitis (VE) compared with a control group. The VE group displayed a wide range of neurological symptoms. Virological analysis revealed the predominance of Herpesviridae family viruses. Immune responses in cerebrospinal fluid (CSF) from patients with VE were examined, highlighting an immunological shift toward T helper 1 (Th1) cells dominance, altered T helper 17 cells/regulatory T cells (Th17/Tregs) balance, and high interleukin-6 expression. These findings provide insights into the complex immunological landscape of VE, highlighting the role of specific cytokines and T cell subsets in its pathogenesis and potentially guiding targeted therapeutic strategies.</p>","PeriodicalId":23665,"journal":{"name":"Viral immunology","volume":" ","pages":""},"PeriodicalIF":1.5000,"publicationDate":"2024-11-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Viral immunology","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1089/vim.2024.0058","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"IMMUNOLOGY","Score":null,"Total":0}
引用次数: 0
Abstract
This study investigates the demographic, clinical characteristics, virological profiles, and immunological responses of patients with viral encephalitis (VE) compared with a control group. The VE group displayed a wide range of neurological symptoms. Virological analysis revealed the predominance of Herpesviridae family viruses. Immune responses in cerebrospinal fluid (CSF) from patients with VE were examined, highlighting an immunological shift toward T helper 1 (Th1) cells dominance, altered T helper 17 cells/regulatory T cells (Th17/Tregs) balance, and high interleukin-6 expression. These findings provide insights into the complex immunological landscape of VE, highlighting the role of specific cytokines and T cell subsets in its pathogenesis and potentially guiding targeted therapeutic strategies.
本研究调查了病毒性脑炎（VE）患者与对照组相比在人口统计学、临床特征、病毒学特征和免疫学反应方面的差异。病毒性脑炎组患者表现出多种神经系统症状。病毒学分析显示，主要是疱疹病毒科病毒。对 VE 患者脑脊液（CSF）中的免疫反应进行了研究，结果表明免疫学转向 T 辅助细胞 1（Th1）占优势、T 辅助细胞 17 细胞/调节性 T 细胞（Th17/Tregs）平衡发生改变以及白细胞介素-6 高表达。这些发现有助于深入了解 VE 复杂的免疫学特征，突出了特定细胞因子和 T 细胞亚群在其发病机制中的作用，并有可能为靶向治疗策略提供指导。
期刊介绍：
Viral Immunology delivers cutting-edge peer-reviewed research on rare, emerging, and under-studied viruses, with special focus on analyzing mutual relationships between external viruses and internal immunity. Original research, reviews, and commentaries on relevant viruses are presented in clinical, translational, and basic science articles for researchers in multiple disciplines.
Viral Immunology coverage includes:
Human and animal viral immunology
Research and development of viral vaccines, including field trials
Immunological characterization of viral components
Virus-based immunological diseases, including autoimmune syndromes
Pathogenic mechanisms
Viral diagnostics
Tumor and cancer immunology with virus as the primary factor
Viral immunology methods.
京公网安备 11010802042870号
京ICP备2023020795号-1
分享
求助内容：
应助结果提醒方式：
扫码关注我们
