Sodium alginate/carboxymethylcellulose gel formulations containing Capparis sepieria plant extract for wound healing.

IF 3 Q2 PHARMACOLOGY & PHARMACY Therapeutic delivery Pub Date : 2024-11-12 DOI:10.1080/20415990.2024.2418800

Sindi P Ndlovu, Shirley C M Motaung, Samson A Adeyemi, Philemon Ubanako, Lindokuhle M Ngema, Thierry Youmbi Fonkui, Derek Tantoh Ndinteh, Pradeep Kumar, Yahya E Choonara, Blessing A Aderibigbe

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Abstract

Aim: Using appropriate wound dressings is crucial when treating burn wounds to promote accelerated healing.Materials & methods: Sodium alginate (SA)-based gels containing Carboxymethyl cellulose (CMC) and Pluronic F127 were prepared. The formulations. SA/CMC/Carbopol and SA/CMC/PluronicF127 were loaded with aqueous root extract of Capparis sepiaria. The formulations were characterized using appropriate techniques.Results: The gels' viscosity was in the range of 676.33 ± 121.76 to 20.00 ± 9.78 cP and in vitro whole blood kinetics showed their capability to induce a faster clotting rate. They also supported high cell viability of 80% with cellular migration and proliferation. Their antibacterial activity was significant against most bacteria strains used in the study.Conclusion: The gels' distinct features reveal their potential application as wound dressings for burn wounds.

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海藻酸钠/羧甲基纤维素凝胶配方，含用于伤口愈合的蓝花楹植物提取物。

目的：在治疗烧伤伤口时，使用适当的伤口敷料对促进伤口加速愈合至关重要：制备了含有羧甲基纤维素（CMC）和Pluronic F127的海藻酸钠（SA）凝胶。配方。在 SA/CMC/Carbopol 和 SA/CMC/PluronicF127 中添加了蓝花楹（Capparis sepiaria）的水性根提取物。采用适当的技术对配方进行了表征：凝胶的粘度在 676.33 ± 121.76 到 20.00 ± 9.78 cP 之间，体外全血动力学显示它们能够加快凝血速度。它们还支持高达 80% 的细胞存活率以及细胞迁移和增殖。它们对研究中使用的大多数细菌菌株都有显著的抗菌活性：凝胶的独特特性揭示了其作为烧伤伤口敷料的潜在应用。

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来源期刊

Therapeutic delivery PHARMACOLOGY & PHARMACY-

CiteScore

5.50

自引率

0.00%

发文量

期刊介绍： Delivering therapeutics in a way that is right for the patient - safe, painless, reliable, targeted, efficient and cost effective - is the fundamental aim of scientists working in this area. Correspondingly, this evolving field has already yielded a diversity of delivery methods, including injectors, controlled release formulations, drug eluting implants and transdermal patches. Rapid technological advances and the desire to improve the efficacy and safety profile of existing medications by specific targeting to the site of action, combined with the drive to improve patient compliance, continue to fuel rapid research progress. Furthermore, the emergence of cell-based therapeutics and biopharmaceuticals such as proteins, peptides and nucleotides presents scientists with new and exciting challenges for the application of therapeutic delivery science and technology. Successful delivery strategies increasingly rely upon collaboration across a diversity of fields, including biology, chemistry, pharmacology, nanotechnology, physiology, materials science and engineering. Therapeutic Delivery recognizes the importance of this diverse research platform and encourages the publication of articles that reflect the highly interdisciplinary nature of the field. In a highly competitive industry, Therapeutic Delivery provides the busy researcher with a forum for the rapid publication of original research and critical reviews of all the latest relevant and significant developments, and focuses on how the technological, pharmacological, clinical and physiological aspects come together to successfully deliver modern therapeutics to patients. The journal delivers this essential information in concise, at-a-glance article formats that are readily accessible to the full spectrum of therapeutic delivery researchers.