Chromosome Engineering: Technologies, Applications, and Challenges.

IF 8.7 1区农林科学 Q1 AGRICULTURE, DAIRY & ANIMAL SCIENCE Annual Review of Animal Biosciences Pub Date : 2024-11-14 DOI:10.1146/annurev-animal-111523-102225

Yihuan Mao, Yulong Zhao, Qi Zhou, Wei Li

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Abstract

Chromosome engineering is a transformative field at the cutting edge of biological science, offering unprecedented precision in manipulating large-scale genomic DNA within cells. This discipline is central to deciphering how the multifaceted roles of chromosomes-guarding genetic information, encoding sequence positional information, and influencing organismal traits-shape the genetic blueprint of life. This review comprehensively examines the technological advancements in chromosome engineering, which center on engineering chromosomal rearrangements, generating artificial chromosomes, de novo synthesizing chromosomes, and transferring chromosomes. Additionally, we introduce the application progress of chromosome engineering in basic and applied research fields, showcasing its capacity to deepen our knowledge of genetics and catalyze breakthroughs in therapeutic strategies. Finally, we conclude with a discussion of the challenges the field faces and highlight the profound implications that chromosome engineering holds for the future of modern biology and medical applications.

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染色体工程：技术、应用和挑战。

染色体工程是生物科学最前沿的一个变革性领域，它能以前所未有的精确度操纵细胞内的大规模基因组 DNA。这门学科是破解染色体如何发挥多方面作用--保护遗传信息、编码序列位置信息和影响生物体性状--塑造生命遗传蓝图的核心。本综述全面探讨了染色体工程的技术进展，主要包括染色体重排工程、人工染色体生成、染色体从头合成和染色体转移。此外，我们还介绍了染色体工程在基础研究和应用研究领域的应用进展，展示了染色体工程在深化遗传学知识和促进治疗策略突破方面的能力。最后，我们讨论了该领域面临的挑战，并强调了染色体工程对现代生物学和医学应用的未来所具有的深远影响。

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来源期刊

Annual Review of Animal Biosciences BIOTECHNOLOGY & APPLIED MICROBIOLOGY-ZOOLOGY

CiteScore

21.30

自引率

0.80%

发文量

期刊介绍： The Annual Review of Animal Biosciences is primarily dedicated to the fields of biotechnology, genetics, genomics, and breeding, with a special focus on veterinary medicine. This includes veterinary pathobiology, infectious diseases and vaccine development, and conservation and zoo biology. The publication aims to address the needs of scientists studying both wild and domesticated animal species, veterinarians, conservation biologists, and geneticists.