Rumen-Targeted Mining of Enzymes for Bioenergy Production.

IF 8.7 1区农林科学 Q1 AGRICULTURE, DAIRY & ANIMAL SCIENCE Annual Review of Animal Biosciences Pub Date : 2024-11-14 DOI:10.1146/annurev-animal-021022-030040

Isaac Cann, Yanfen Cheng, Manal A B Alhawsawi, Mallory Moran, Yuqi Li, Tian Gong, Weiyun Zhu, Roderick I Mackie

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Abstract

Second-generation biofuel production, which aims to convert lignocellulose to liquid transportation fuels, could be transformative in worldwide energy portfolios. A bottleneck impeding its large-scale deployment is conversion of the target polysaccharides in lignocellulose to their unit sugars for microbial fermentation to the desired fuels. Cellulose and hemicellulose, the two major polysaccharides in lignocellulose, are complex in nature, and their interactions with pectin and lignin further increase their recalcitrance to depolymerization. This review focuses on the intricate linkages present in the feedstocks of interest and examines the potential of the enzymes evolved by microbes, in the microbe/ruminant symbiotic relationship, to depolymerize the target polysaccharides. We further provide insights to how a rational and more efficient assembly of rumen microbial enzymes can be reconstituted for lignocellulose degradation. We conclude by expounding on how gains in this area can impact the sustainability of both animal agriculture and the energy sector.

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以瘤胃为目标挖掘用于生物能源生产的酶。

第二代生物燃料的生产旨在将木质纤维素转化为液体运输燃料，它可以改变全球能源组合。阻碍其大规模应用的瓶颈是将木质纤维素中的目标多糖转化为微生物发酵所需的单位糖。纤维素和半纤维素是木质纤维素中的两种主要多糖，性质复杂，它们与果胶和木质素的相互作用进一步增加了它们对解聚的不稳定性。本综述重点关注相关原料中存在的复杂联系，并研究微生物/反刍动物共生关系中微生物进化出的酶解聚目标多糖的潜力。我们进一步深入探讨了如何合理、更有效地重组瘤胃微生物酶，以实现木质纤维素降解。最后，我们阐述了这一领域的成果如何影响畜牧业和能源行业的可持续性。

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来源期刊

Annual Review of Animal Biosciences BIOTECHNOLOGY & APPLIED MICROBIOLOGY-ZOOLOGY

CiteScore

21.30

自引率

0.80%

发文量

期刊介绍： The Annual Review of Animal Biosciences is primarily dedicated to the fields of biotechnology, genetics, genomics, and breeding, with a special focus on veterinary medicine. This includes veterinary pathobiology, infectious diseases and vaccine development, and conservation and zoo biology. The publication aims to address the needs of scientists studying both wild and domesticated animal species, veterinarians, conservation biologists, and geneticists.