Impact of vaginal seeding on the gut microbiome of infants born via cesarean section: A systematic review.

IF 14.3 1区医学 Q1 INFECTIOUS DISEASES Journal of Infection Pub Date : 2024-11-12 DOI:10.1016/j.jinf.2024.106348

Xiaochuan Wang, Hong Cui, Na Li, Borui Liu, Xiaoyan Zhang, Jing Yang, Ju-Sheng Zheng, Chong Qiao, Hui-Xin Liu, Jiajin Hu, Deliang Wen

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Abstract

Objective: This systematic review summarizes eight studies involving 558 cesarean section (CS)-born infants (274 exposed to vaginal seeding (VS), 284 not exposed) and 261 infants born vaginally to investigate the effect of VS on gut microbiome colonization and development in CS-born infants.

Methods: This study adhered to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines. Relevant articles published before March 6, 2024, were identified through systematic searches of PubMed, Scopus, and Web of Science. We included experimental studies that investigated changes in the gut microbiota of CS-born infants following VS and reported changes in the gut microbiota. The relationship between VS and the gut microbiota composition of CS-born infants was assessed.

Results: VS may selectively influence the abundance of bacterial genera from various phyla, such as an increased relative abundance of Bacteroides and Lactobacillus, in the gut microbiome of CS-seeded infants compared to CS-non-seeded infants. Conflicting results mainly concern microbial diversity.

Conclusions: Current evidence indicates modest changes in the gut microbiome of CS-born infants following VS. However, further clinical studies are necessary to fully understand its impact on early-life health outcomes, particularly regarding potential microbiome alterations and associated health risks.

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阴道播种对剖腹产婴儿肠道微生物组的影响：系统回顾

目的：本系统综述总结了涉及 558 例剖宫产（CS）新生儿（274 例暴露于阴道播种（VS），284 例未暴露）和 261 例阴道分娩新生儿的 8 项研究，以探讨 VS 对剖宫产新生儿肠道微生物组定植和发育的影响：本研究遵循《系统综述和元分析首选报告项目》指南。通过对 PubMed、Scopus 和 Web of Science 进行系统检索，确定了 2024 年 3 月 6 日之前发表的相关文章。我们纳入了调查 VS 后 CS 出生婴儿肠道微生物群变化的实验研究，并报告了肠道微生物群的变化。我们还评估了 VS 与 CS 出生婴儿肠道微生物群组成之间的关系：结果：VS 可能会选择性地影响不同门类细菌属的丰度，例如，与未添加 VS 的婴儿相比，添加 VS 的婴儿肠道微生物群中乳酸杆菌和乳酸杆菌的相对丰度增加。相互矛盾的结果主要涉及微生物多样性：目前的证据表明，VS 后 CS 出生婴儿的肠道微生物组发生了适度变化。然而，有必要开展进一步的临床研究，以充分了解其对生命早期健康结果的影响，尤其是潜在的微生物组改变和相关的健康风险。

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来源期刊

Journal of Infection 医学-传染病学

CiteScore

45.90

自引率

3.20%

发文量

475

审稿时长

16 days

期刊介绍： The Journal of Infection publishes original papers on all aspects of infection - clinical, microbiological and epidemiological. The Journal seeks to bring together knowledge from all specialties involved in infection research and clinical practice, and present the best work in the ever-changing field of infection. Each issue brings you Editorials that describe current or controversial topics of interest, high quality Reviews to keep you in touch with the latest developments in specific fields of interest, an Epidemiology section reporting studies in the hospital and the general community, and a lively correspondence section.