Changes in senescence markers after a weight loss intervention in older adults with obesity

IF 3.5 3区医学 Q2 GERIATRICS & GERONTOLOGY Archives of gerontology and geriatrics Pub Date : 2024-11-07 DOI:10.1016/j.archger.2024.105685

David H. Lynch , Curtis L. Petersen , Delisha Stewart , Jamie N. Justice , Dakota J Batchek , Susan Sumner , Susan McRitchie , John A. Batsis

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Abstract

Background

Understanding how weight loss interventions in older adults with obesity impact aging biology can lay the foundation for targeted, ‘geroscience-based’ interventions. This study examines the association between changes in the senescence-associated secretory phenotypes (SASP) and changes in function in response to a weight loss intervention.

Methods

We conducted a post-hoc biomarker analysis on adults aged ≥ 65 years with body mass index [BMI] ≥30 kg/m² enrolled in a six-month, non-randomized telemedicine-delivered weight loss intervention. We assessed 16 SASP cytokines using serum samples collected pre-and post-intervention. Clinical outcomes include anthropometric and physical function measurements. A weight loss responder was defined as a loss of ≥5 % of body weight.

Results

Mean age was 73.2 ± 3.9 years (73 % female), and BMI was 36.5 ± 5.2 kg/m². Responders lost 7.6 ± 2.5 %, while non-responders lost 2.0 ± 2.3 % of weight (n = 16 per group, p < 0.001). We observed several significant associations between SASP cytokines and physical function and anthropometric measurement outcomes in age- and sex-adjusted linear models. These included grip strength and Interleukin-8 (IL-8) (b = 9.07) and Insulin-like Growth Factor 1 (IGF-1) (b = 2.6); gait speed and Thymus and Activation-Regulated Chemokine (TARC) (b = 0.46) and IL-7(b = 61 0.11); weight IL-6 (b = -6.77) and IL-15 (b = -2.53); BMI and IL-15 (b = -0.95); waist-to-hip ratio and osteopontin (b = -0.07) (p < 0.05 for all).

Conclusions

Our pilot data demonstrated an association between changes in select SASP biomarkers and increased functional ability with intentional weight loss in older adults with obesity. However, findings must be replicated in prospective randomized trials with a control group and additional SASP biomarkers.

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对肥胖症老年人进行减肥干预后衰老标志物的变化。

背景：了解对患有肥胖症的老年人采取的减肥干预措施如何影响衰老生物学，可为采取有针对性的、"基于科学 "的干预措施奠定基础。本研究探讨了衰老相关分泌表型（SASP）的变化与减肥干预后功能变化之间的关联：我们对体重指数[BMI]≥30 kg/m2、年龄≥65岁的成年人进行了一项事后生物标志物分析，这些成年人参加了为期六个月的非随机远程医疗减肥干预。我们使用干预前后采集的血清样本评估了 16 种 SASP 细胞因子。临床结果包括人体测量和身体功能测量。体重下降≥5%即为减肥反应者：平均年龄为 73.2 ± 3.9 岁（73% 为女性），体重指数为 36.5 ± 5.2 kg/m2。有反应者体重减轻了 7.6 ± 2.5%，无反应者体重减轻了 2.0 ± 2.3%（每组 16 人，P < 0.001）。在年龄和性别调整线性模型中，我们观察到 SASP 细胞因子与身体功能和人体测量结果之间存在几种重要的关联。其中包括握力与白细胞介素-8（IL-8）（b = 9.07）和胰岛素样生长因子 1（IGF-1）（b = 2.6）；步速与胸腺和激活调节的趋化因子（TARC）（b = 0.46）和 IL-7（b = 61 0.11）；体重 IL-6（b = -6.77）和 IL-15（b = -2.53）；体重指数（BMI）和 IL-15（b = -0.95）；腰臀比和骨质素（b = -0.07）（所有数据的 p < 0.05）：我们的试验数据表明，在有意减轻肥胖症老年人体重的情况下，某些 SASP 生物标志物的变化与功能能力的提高之间存在关联。然而，这些研究结果必须在有对照组和其他 SASP 生物标志物的前瞻性随机试验中得到证实。

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来源期刊

Archives of gerontology and geriatrics 医学-老年医学

CiteScore

7.30

自引率

5.00%

发文量

198

审稿时长

16 days

期刊介绍： Archives of Gerontology and Geriatrics provides a medium for the publication of papers from the fields of experimental gerontology and clinical and social geriatrics. The principal aim of the journal is to facilitate the exchange of information between specialists in these three fields of gerontological research. Experimental papers dealing with the basic mechanisms of aging at molecular, cellular, tissue or organ levels will be published. Clinical papers will be accepted if they provide sufficiently new information or are of fundamental importance for the knowledge of human aging. Purely descriptive clinical papers will be accepted only if the results permit further interpretation. Papers dealing with anti-aging pharmacological preparations in humans are welcome. Papers on the social aspects of geriatrics will be accepted if they are of general interest regarding the epidemiology of aging and the efficiency and working methods of the social organizations for the health care of the elderly.