Chromosome-level genome assembly and annotation of the crested gecko, Correlophus ciliatus, a lizard incapable of tail regeneration.

GigaByte (Hong Kong, China) Pub Date : 2024-11-06 eCollection Date: 2024-01-01 DOI:10.46471/gigabyte.140

Marc A Gumangan, Zheyu Pan, Thomas P Lozito

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Abstract

The vast majority of gecko species are capable of tail regeneration, but singular geckos of Correlophus, Uroplatus, and Nephrurus genera are unable to regrow lost tails. Of these non-regenerative geckos, the crested gecko (Correlophus ciliatus) is distinguished by ready availability, ease of care, high productivity, and hybridization potential. These features make C. ciliatus particularly suited as a model for studying the genetic, molecular, and cellular mechanisms underlying loss of tail regeneration capabilities. We report a contiguous genome of C. ciliatus with a total size of 1.65 Gb, 152 scaffolds, L50 of 6, and N50 of 109 Mb. Repetitive content consists of 40.41% of the genome, and a total of 30,780 genes were annotated. Our assembly of the crested gecko genome provides a valuable resource for future comparative genomic studies between non-regenerative and regenerative geckos and other squamate reptiles.

Findings: We report genome sequencing, assembly, and annotation for the crested gecko, Correlophus ciliatus.

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冠壁虎（Correlophus ciliatus）染色体水平的基因组组装和注释，冠壁虎是一种无法进行尾部再生的蜥蜴。

绝大多数壁虎物种都具有尾巴再生能力，但Correlophus属、Uroplatus属和Nephrurus属的奇特壁虎无法再生失去的尾巴。在这些不具备再生能力的壁虎中，冠壁虎（Correlophus ciliatus）的特点是随时可用、易于照料、产量高且具有杂交潜力。这些特点使冠壁虎特别适合作为研究尾部再生能力丧失的遗传、分子和细胞机制的模型。我们报告的纤毛虫连续基因组总大小为 1.65 Gb，有 152 个支架，L50 为 6，N50 为 109 Mb。重复内容占基因组的 40.41%，共注释了 30,780 个基因。我们对冠壁虎基因组的组装为未来非再生壁虎和再生壁虎以及其他有鳞类爬行动物的基因组比较研究提供了宝贵的资源：我们报告了冠壁虎（Correlophus ciliatus）的基因组测序、组装和注释。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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