Locally advanced/metastatic non-small-cell lung cancer in Lebanon: focus on ALK tyrosine kinase inhibitors.

IF 3 4区 医学 Q2 ONCOLOGY Future oncology Pub Date : 2024-11-15 DOI:10.1080/14796694.2024.2421737
Arafat Tfayli, Hady Ghanem, Fadi Nasr, Hampig Raphael Kourie, Georges El Hachem, Jamil Debs, Sarah Masri, Hazem I Assi, Rosario García Campelo, Joseph Kattan
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Abstract

Treatment of non-small-cell lung cancers (NSCLC) has evolved over the last decade. According to studies, the use of targeted therapies has significantly increased the life expectancy of patients. Moreover, ALK-tyrosine kinase inhibitors (ALK-TKIs) have improved clinical outcomes. In Lebanon, translating recommendations into clinical practice remains challenging. A Lebanese expert panel of oncologists was convened to describe the management paradigm and the clinical evidence supporting the optimal use of next-generation TKIs in patients with ALK-rearranged NSCLC and to provide an expert overview of local challenges and recommendations for optimizing the management of advanced NSCLC in Lebanese patients. The experts agreed that these recommendations should be part of a healthcare strategy to be implemented at the national level.

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黎巴嫩的局部晚期/转移性非小细胞肺癌:关注 ALK 酪氨酸激酶抑制剂。
过去十年来,非小细胞肺癌(NSCLC)的治疗不断发展。研究显示,靶向疗法的使用大大延长了患者的预期寿命。此外,ALK-酪氨酸激酶抑制剂(ALK-TKIs)也改善了临床疗效。在黎巴嫩,将建议转化为临床实践仍具有挑战性。我们召集了一个由黎巴嫩肿瘤专家组成的专家小组,以描述支持在 ALK 重组 NSCLC 患者中优化使用新一代 TKIs 的管理模式和临床证据,并提供有关当地挑战的专家概述和优化黎巴嫩晚期 NSCLC 患者管理的建议。专家们一致认为,这些建议应成为在国家层面实施的医疗保健战略的一部分。
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来源期刊
Future oncology
Future oncology ONCOLOGY-
CiteScore
5.40
自引率
3.00%
发文量
335
审稿时长
4-8 weeks
期刊介绍: Future Oncology (ISSN 1479-6694) provides a forum for a new era of cancer care. The journal focuses on the most important advances and highlights their relevance in the clinical setting. Furthermore, Future Oncology delivers essential information in concise, at-a-glance article formats - vital in delivering information to an increasingly time-constrained community. The journal takes a forward-looking stance toward the scientific and clinical issues, together with the economic and policy issues that confront us in this new era of cancer care. The journal includes literature awareness such as the latest developments in radiotherapy and immunotherapy, concise commentary and analysis, and full review articles all of which provide key findings, translational to the clinical setting.
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