112° field of view high-resolution swept-source OCT angiography for rat retinas.

IF 3.1 2区物理与天体物理 Q2 OPTICS Optics letters Pub Date : 2024-11-15 DOI:10.1364/OL.538165

Guangru B Liang, Shuibin Ni, Tristan T Hormel, John C Morrison, Diana C Lozano, Yifan Jian, J Peter Campbell, Yali Jia

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Abstract

This study introduces an ultra-wide field (UWF) and high-resolution swept-source optical coherence tomographic angiography (OCTA) system for rat retinal imaging. Using an asymmetrical optics design, the system achieves unprecedented details of retinal structures and vascular plexuses over a large field of view (112°) in a single-shot acquisition. Views of single-nerve fiber bundles and single capillary vessels are consistently visible over a 112° field of view. The system has a long imaging range and high penetration and allows a full view of vitreous hyaloid vessels, retina, choroid, sclera, and posterior ciliary arteries, down to sub-sclera connective tissues. In a longitudinal study of oxygen-induced retinopathy (OIR) in rats, the system successfully revealed the progression and regression of OIR-related vascular pathologies, such as ischemia, neovascularization, and tortuosity. To our knowledge, this novel UWF-OCT/OCTA prototype designed for rat retinal imaging will be a vital tool for monitoring disease progression and evaluating therapeutic interventions in preclinical models.

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用于大鼠视网膜的 112° 视场高分辨率扫源 OCT 血管造影。

本研究介绍了一种用于大鼠视网膜成像的超宽视场（UWF）和高分辨率扫源光学相干断层血管成像（OCTA）系统。该系统采用非对称光学设计，可在大视野（112°）范围内通过单次采集获得前所未有的视网膜结构和血管丛细节。在 112° 的视场范围内，单神经纤维束和单根毛细血管的图像始终清晰可见。该系统成像范围大、穿透力强，可全面观察玻璃体透明血管、视网膜、脉络膜、巩膜和睫状体后动脉，直至巩膜下结缔组织。在对大鼠氧诱导视网膜病变（OIR）的纵向研究中，该系统成功揭示了与 OIR 相关的血管病变（如缺血、新生血管和迂曲）的进展和消退。据我们所知，这种专为大鼠视网膜成像设计的新型 UWF-OCT/OCTA 原型将成为在临床前模型中监测疾病进展和评估治疗干预措施的重要工具。

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来源期刊

Optics letters 物理-光学

CiteScore

6.60

自引率

8.30%

发文量

2275

审稿时长

1.7 months

期刊介绍： The Optical Society (OSA) publishes high-quality, peer-reviewed articles in its portfolio of journals, which serve the full breadth of the optics and photonics community. Optics Letters offers rapid dissemination of new results in all areas of optics with short, original, peer-reviewed communications. Optics Letters covers the latest research in optical science, including optical measurements, optical components and devices, atmospheric optics, biomedical optics, Fourier optics, integrated optics, optical processing, optoelectronics, lasers, nonlinear optics, optical storage and holography, optical coherence, polarization, quantum electronics, ultrafast optical phenomena, photonic crystals, and fiber optics. Criteria used in determining acceptability of contributions include newsworthiness to a substantial part of the optics community and the effect of rapid publication on the research of others. This journal, published twice each month, is where readers look for the latest discoveries in optics.