β-Cyclodextrin-SO3H as a Supramolecular Catalyst for Efficient Greener Synthesis of Substituted Bis(6-aminouracil-5-yl)methanes in Water

Abstract

A simple, straightforward, and highly efficient greener approach for synthesizing bis(6-aminouracil-5-yl)methane derivatives was developed by employing β-cyclodextrin-SO₃H as supramolecular catalyst in water at 100 °C. A total of 16 bis(6-aminouracil-5-yl)methanes were synthesized via a one-pot reaction between substituted aromatic aldehydes, 6-amino-1,3-dimethyluracil, and 10% β-cyclodextrin-SO₃H in water with 84%–92% yield within 20–120 min. The salient features of this protocol included water as green solvent, β-cyclodextrin-SO₃H as recyclable supramolecular catalyst, mild reaction conditions, easy isolation of pure products, and good to excellent yields.