Lanfeng He, Enhua Wang, Shuang Zheng, Yingguo Ban, Kaiping Hou, Dr. Lishou Yang, Dr. Xiaosheng Yang
{"title":"Diethyl Phosphate-Catalyzed One-Pot Synthesis of 2,3-Dihydroquinolin-4(1H)-ones from 2-Aminoacetophenones and Benzaldehydes","authors":"Lanfeng He, Enhua Wang, Shuang Zheng, Yingguo Ban, Kaiping Hou, Dr. Lishou Yang, Dr. Xiaosheng Yang","doi":"10.1002/slct.202404028","DOIUrl":null,"url":null,"abstract":"<p>A diethyl phosphate (DEP)-catalyzed one-pot synthesis of 2,3-dihydroquinolin-4(1<i>H</i>)-ones in DMF was achieved. Control experiments led to a plausible mechanism involving an intermolecular aldol condensation of 2-aminoacetophenone and aldehyde, followed by a hydrogen bond-driven cyclization. In this process, a series of 2,3-dihydroquinolin-4(1<i>H</i>)-ones were obtained in good yields (48–84%). This strategy features transition metal-free and short reaction times.</p>","PeriodicalId":146,"journal":{"name":"ChemistrySelect","volume":"9 43","pages":""},"PeriodicalIF":1.9000,"publicationDate":"2024-11-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"ChemistrySelect","FirstCategoryId":"92","ListUrlMain":"https://onlinelibrary.wiley.com/doi/10.1002/slct.202404028","RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"CHEMISTRY, MULTIDISCIPLINARY","Score":null,"Total":0}
引用次数: 0
Abstract
A diethyl phosphate (DEP)-catalyzed one-pot synthesis of 2,3-dihydroquinolin-4(1H)-ones in DMF was achieved. Control experiments led to a plausible mechanism involving an intermolecular aldol condensation of 2-aminoacetophenone and aldehyde, followed by a hydrogen bond-driven cyclization. In this process, a series of 2,3-dihydroquinolin-4(1H)-ones were obtained in good yields (48–84%). This strategy features transition metal-free and short reaction times.
期刊介绍：
ChemistrySelect is the latest journal from ChemPubSoc Europe and Wiley-VCH. It offers researchers a quality society-owned journal in which to publish their work in all areas of chemistry. Manuscripts are evaluated by active researchers to ensure they add meaningfully to the scientific literature, and those accepted are processed quickly to ensure rapid online publication.
京公网安备 11010802042870号
京ICP备2023020795号-1
分享
求助内容：
应助结果提醒方式：
扫码关注我们
