Biomimetic drug delivery for anticancer: Focusing on the relationship between drugs and biomimetic carriers

IF 20.3 1区化学 Q1 CHEMISTRY, INORGANIC & NUCLEAR Coordination Chemistry Reviews Pub Date : 2024-11-16 DOI:10.1016/j.ccr.2024.216328

Tian Liu , Qi Lu , Hao Zhang , Fudan Dong , Zhonggui He , Jin Sun , Bingjun Sun

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Abstract

Biomimetic carriers utilizing cells and cellular components revolutionize the field of anticancer drug delivery systems. Existing reviews in this field have predominantly approached biomimetic drug delivery systems by focusing on either the carrier or the payload. However, recognizing the intrinsic inseparability of the drug and the biomimetic carrier is imperative, as their mutual influences decisively shape the drug delivery system. This review delineated the recent progress in biomimetic carriers for antitumor therapeutics from a distinct perspective, concentrating on the relationship between the drug and the carrier. The relationship involves drug-loading mode, the loading position, and the mechanism of drug-release strategies. This review highlighted the crucial roles of drug loading morphologies and loading positions in enhancing the efficiency of carrier delivery and overcoming barriers to cancer treatment. Additionally, innovative strategies for controlled drug release from biomimetic carriers were summarized, and an extensive discussion on the future prospects and potential challenges in this field was provided.

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用于抗癌的生物仿生给药：关注药物与生物仿生载体之间的关系

利用细胞和细胞成分的仿生载体彻底改变了抗癌药物递送系统领域。该领域的现有评论主要通过关注载体或有效载荷来探讨生物仿生给药系统。然而，认识到药物与生物仿生载体之间不可分割的内在联系势在必行，因为它们之间的相互影响对给药系统起着决定性作用。这篇综述从一个独特的视角阐述了抗肿瘤治疗生物仿生载体的最新进展，集中探讨了药物与载体之间的关系。这种关系涉及药物负载模式、负载位置和药物释放策略机制。这篇综述强调了药物装载形态和装载位置在提高载体递送效率和克服癌症治疗障碍方面的关键作用。此外，还总结了仿生载体控释药物的创新策略，并对该领域的未来前景和潜在挑战进行了广泛讨论。

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来源期刊

Coordination Chemistry Reviews 化学-无机化学与核化学

CiteScore

34.30

自引率

5.30%

发文量

457

审稿时长

54 days

期刊介绍： Coordination Chemistry Reviews offers rapid publication of review articles on current and significant topics in coordination chemistry, encompassing organometallic, supramolecular, theoretical, and bioinorganic chemistry. It also covers catalysis, materials chemistry, and metal-organic frameworks from a coordination chemistry perspective. Reviews summarize recent developments or discuss specific techniques, welcoming contributions from both established and emerging researchers. The journal releases special issues on timely subjects, including those featuring contributions from specific regions or conferences. Occasional full-length book articles are also featured. Additionally, special volumes cover annual reviews of main group chemistry, transition metal group chemistry, and organometallic chemistry. These comprehensive reviews are vital resources for those engaged in coordination chemistry, further establishing Coordination Chemistry Reviews as a hub for insightful surveys in inorganic and physical inorganic chemistry.