Electrochemically Induced, Metal Free Synthesis of 2-substituted chroman-4-ones

IF 3.1 4区 化学 Q2 CHEMISTRY, MULTIDISCIPLINARY ChemistryOpen Pub Date : 2024-11-16 DOI:10.1002/open.202400395
Mohsen Monirialamdari, Aleksandra Podlaska, Dominika Pomikło, Anna Albrecht
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Abstract

Electrochemically induced, decarboxylative functionalization of chromone-3-carboxylic acids by N-hydroxyphthalimide esters as alkyl radical precursors was studied. Electrochemical protocol offers a sustainable and green approach, obviating the need for catalysts, relying on the direct reduction of NHPI esters using electric current. Developed protocol provides a straightforward route to the synthesis of diverse molecules with potential biological activity.

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电化学诱导的 2-取代色满-4-酮的无金属合成。
研究了以 N-羟基邻苯二甲酰亚胺酯为烷基自由基前体,通过电化学方法诱导色酮-3-羧酸的脱羧功能化。电化学方案提供了一种可持续的绿色方法,无需催化剂,依靠电流直接还原 NHPI 酯。所开发的方案为合成具有潜在生物活性的多种分子提供了一条直接的途径。
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来源期刊
ChemistryOpen
ChemistryOpen CHEMISTRY, MULTIDISCIPLINARY-
CiteScore
4.80
自引率
4.30%
发文量
143
审稿时长
1 months
期刊介绍: ChemistryOpen is a multidisciplinary, gold-road open-access, international forum for the publication of outstanding Reviews, Full Papers, and Communications from all areas of chemistry and related fields. It is co-owned by 16 continental European Chemical Societies, who have banded together in the alliance called ChemPubSoc Europe for the purpose of publishing high-quality journals in the field of chemistry and its border disciplines. As some of the governments of the countries represented in ChemPubSoc Europe have strongly recommended that the research conducted with their funding is freely accessible for all readers (Open Access), ChemPubSoc Europe was concerned that no journal for which the ethical standards were monitored by a chemical society was available for such papers. ChemistryOpen fills this gap.
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