A. V. Terekhova, A. V. Petrova, O. B. Kazakova, Yu.V. Vakhitova, D. N. Polovyanenko, I. Yu. Bagryanskaya
{"title":"Acylation of Azepanoglycyrrhetol","authors":"A. V. Terekhova, A. V. Petrova, O. B. Kazakova, Yu.V. Vakhitova, D. N. Polovyanenko, I. Yu. Bagryanskaya","doi":"10.1007/s10600-024-04521-1","DOIUrl":null,"url":null,"abstract":"<p>Acylation of azepano-11-deoxoglycyrrhetol synthesized<i> N</i>-acetyl- and <i>N,O</i>-bis-acetyl derivatives. The structure of azepano-11-deoxoglycyrrhetol was confirmed by an XSA. Data for its influence on cell cycle progression suggested that suppression of cell survival was due primarily to a cytostatic effect that was related to arrest of the S or G1 phase, depending on the cell line.</p>","PeriodicalId":514,"journal":{"name":"Chemistry of Natural Compounds","volume":"60 6","pages":"1066 - 1071"},"PeriodicalIF":0.8000,"publicationDate":"2024-11-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Chemistry of Natural Compounds","FirstCategoryId":"92","ListUrlMain":"https://link.springer.com/article/10.1007/s10600-024-04521-1","RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"CHEMISTRY, MEDICINAL","Score":null,"Total":0}
引用次数: 0
Abstract
Acylation of azepano-11-deoxoglycyrrhetol synthesized N-acetyl- and N,O-bis-acetyl derivatives. The structure of azepano-11-deoxoglycyrrhetol was confirmed by an XSA. Data for its influence on cell cycle progression suggested that suppression of cell survival was due primarily to a cytostatic effect that was related to arrest of the S or G1 phase, depending on the cell line.
期刊介绍:
Chemistry of Natural Compounds publishes reviews and general articles about the structure of different classes of natural compounds, the chemical characteristics of botanical families, genus, and species, to establish the comparative laws and connection between physiological activity and the structure of substances.