{"title":"Secondary Metabolites of Two Desert Endophytic Fungi Neocamarosporum sp. and Alternaria sp.","authors":"Hua-Yang Pan, Hua-Guang Liu, Hui-Ying Liu, Yu Liu, Shuang-Mei Yan, Xiao-Long Zhao, Du-Qiang Luo","doi":"10.1007/s10600-024-04511-3","DOIUrl":null,"url":null,"abstract":"<p>Four new compounds (<b>1</b>–<b>4</b>) along with twelve known compounds (<b>5</b>–<b>16</b>) were isolated from the fermentation broth of two desert endophytic fungi Neocamarosporum sp. HM 175 and Alternaria sp. HM 213. The structures of the compounds were elucidated by ESI-MS and NMR data. The PTP1B inhibitory activity results showed that compounds <b>2</b>, <b>5</b>, <b>11</b>, <b>12</b>, and <b>13</b> exhibited certain inhibitory activity on PTP1B. The activity test of these compounds provided potential drug lead compounds for the research and development of new PTP1B inhibitors.</p>","PeriodicalId":514,"journal":{"name":"Chemistry of Natural Compounds","volume":"60 6","pages":"1021 - 1028"},"PeriodicalIF":0.8000,"publicationDate":"2024-11-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Chemistry of Natural Compounds","FirstCategoryId":"92","ListUrlMain":"https://link.springer.com/article/10.1007/s10600-024-04511-3","RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"CHEMISTRY, MEDICINAL","Score":null,"Total":0}
引用次数: 0
Abstract
Four new compounds (1–4) along with twelve known compounds (5–16) were isolated from the fermentation broth of two desert endophytic fungi Neocamarosporum sp. HM 175 and Alternaria sp. HM 213. The structures of the compounds were elucidated by ESI-MS and NMR data. The PTP1B inhibitory activity results showed that compounds 2, 5, 11, 12, and 13 exhibited certain inhibitory activity on PTP1B. The activity test of these compounds provided potential drug lead compounds for the research and development of new PTP1B inhibitors.
期刊介绍：
Chemistry of Natural Compounds publishes reviews and general articles about the structure of different classes of natural compounds, the chemical characteristics of botanical families, genus, and species, to establish the comparative laws and connection between physiological activity and the structure of substances.
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