Association between sleep quality and cognitive impairment in older adults hypertensive patients in China: a case-control study.

IF 3 3区医学 Q2 PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH Frontiers in Public Health Pub Date : 2024-11-01 eCollection Date: 2024-01-01 DOI:10.3389/fpubh.2024.1446781

Shunxin Lv, Huachen Jiao, Xia Zhong, Ying Qu, Mengdi Zhang, Rui Wang, Donghai Liu

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Abstract

Background: Previous studies have found that poor sleep quality promotes the occurrence of cognitive impairment (CI), but this relationship has been rarely reported in older adults hypertensive patients. The purpose of this study was to investigate the relationship between sleep quality and CI in older adults hypertensive patients and the mediating effect of sleep quality between physical activity (PA) and CI.

Methods: A total of 2072 older adults hypertensive patients were included in this case-control study. Five hundred and eighteen older adults hypertensive patients with CI were matched 1:3 by age and sex to 1,554 older adults hypertensive patients with normal cognitive function. The International Physical Activity Questionnaire-Long Form, Pittsburgh Sleep Quality Index, and Mini-Mental State Examination were used to evaluate PA intensity, sleep quality, and cognitive function in older adults hypertensive patients. Multivariate logistic regression and the mediation package in R Language were used to analyze the relationship between sleep quality and CI and the mediating effect of sleep quality between PA intensity and CI in older adults hypertensive patients.

Results: After adjusting for all confounding factors, sleep quality was positively correlated with CI in older adults hypertensive patients (OR = 2.565, 95%CI: 1.958-3.360, p < 0.001), and this relationship also existed in the older adults hypertensive patients with education levels of primary school and below and junior high school and above (OR = 2.468, 95%CI: 1.754-3.473, p < 0.001; OR = 2.385, 95%CI: 1.367-4.161, p = 0.002). In addition, sleep quality mediated part of the mediating effect between PA intensity and CI in older adults hypertensive patients (Za*Zb: - 17.19339; 95%CI: -0.37312, -0.04194).

Conclusion: Poor sleep quality was associated with the occurrence of CI in older adults hypertensive patients, and this relationship also existed in older adults hypertensive patients with education levels of primary school and below and junior high school and above.

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中国老年高血压患者睡眠质量与认知障碍的关系：一项病例对照研究。

背景：以往的研究发现，睡眠质量差会促进认知障碍（CI）的发生，但这种关系在老年高血压患者中鲜有报道。本研究旨在探讨老年高血压患者的睡眠质量与认知障碍之间的关系，以及睡眠质量在体力活动（PA）与认知障碍之间的中介作用：这项病例对照研究共纳入了 2072 名老年高血压患者。518 名患有 CI 的老年高血压患者与 1554 名认知功能正常的老年高血压患者按年龄和性别 1:3 配对。研究采用国际体力活动问卷-长表、匹兹堡睡眠质量指数和迷你精神状态检查来评估老年高血压患者的体力活动强度、睡眠质量和认知功能。使用多变量逻辑回归和 R 语言的中介包分析了睡眠质量与认知功能之间的关系，以及睡眠质量在老年高血压患者的 PA 强度与认知功能之间的中介效应：在调整了所有干扰因素后，老年高血压患者的睡眠质量与CI呈正相关（OR = 2.565，95%CI：1.958-3.360，p p = 0.002）。此外，睡眠质量对老年高血压患者 PA 强度与 CI 之间的部分中介效应具有中介作用（Za*Zb：-17.19339；95%CI：-0.37312，-0.04194）：结论：睡眠质量差与老年高血压患者 CI 的发生有关，小学及以下和初中及以上文化程度的老年高血压患者也存在这种关系。

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来源期刊

Frontiers in Public Health Medicine-Public Health, Environmental and Occupational Health

CiteScore

4.80

自引率

7.70%

发文量

4469

审稿时长

14 weeks

期刊介绍： Frontiers in Public Health is a multidisciplinary open-access journal which publishes rigorously peer-reviewed research and is at the forefront of disseminating and communicating scientific knowledge and impactful discoveries to researchers, academics, clinicians, policy makers and the public worldwide. The journal aims at overcoming current fragmentation in research and publication, promoting consistency in pursuing relevant scientific themes, and supporting finding dissemination and translation into practice. Frontiers in Public Health is organized into Specialty Sections that cover different areas of research in the field. Please refer to the author guidelines for details on article types and the submission process.