Association between total, regional and organ fat and type 2 diabetes risk factors among Latino youth: A longitudinal study.

IF 2.7 3区医学 Q1 PEDIATRICS Pediatric Obesity Pub Date : 2024-11-17 DOI:10.1111/ijpo.13185

Eyitayo O Owolabi, Micah L Olson, Houchun H Hu, Armando Peña, Janiel L Pimentel, Keenan A Pituch, Smita S Bailey, Gabriel Q Shaibi

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Abstract

Introduction: To examine whether within-person changes in total, regional and organ fat were associated with within-person changes in type 2 diabetes (T2D)-related biomarkers following interventions.

Methods: A secondary analysis from a randomised trial among Latino youth (30 males, 25 females) aged 12-16 years with obesity. The study sample combined participants randomised to either lifestyle intervention (N = 39) or usual care (N = 16). Total body composition was assessed by DEXA. Hepatic and pancreatic fat fractions were assessed using MRI. T2D risk factors included insulin sensitivity, beta-cell function and post-challenge glucose.

Results: Significant changes in %body fat, lean mass, insulin sensitivity and 2-h glucose were observed. Changes in fat mass were associated with changes in insulin sensitivity (β = -0.45, p < 0.001), while changes in lean mass were associated with changes in 2-h glucose concentrations (β = -0.50, p = 0.02). No association between changes in total, regional, or organ fat and beta cell function were noted.

Conclusions: Our study revealed that within-person changes in fat mass and lean mass were associated with increased insulin sensitivity and reduced 2-h glucose concentrations, respectively, among high-risk Latino youth. The impact of reductions in regional and organ fat deposition on T2D risk factors warrants further examination.

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拉丁裔青少年的总脂肪、区域脂肪和器官脂肪与 2 型糖尿病风险因素之间的关系：一项纵向研究。

简介：目的：研究干预措施后，人体内总脂肪、区域脂肪和器官脂肪的变化是否与2型糖尿病（T2D）相关生物标志物的变化有关：研究人体内总脂肪、区域脂肪和器官脂肪的变化是否与干预后人体内与2型糖尿病（T2D）相关的生物标志物的变化有关：对一项随机试验进行二次分析，研究对象为 12-16 岁患有肥胖症的拉丁裔青少年（男性 30 人，女性 25 人）。研究样本包括随机接受生活方式干预（39 人）或常规护理（16 人）的参与者。身体总成分通过 DEXA 进行评估。肝脏和胰腺脂肪含量通过核磁共振成像进行评估。T2D风险因素包括胰岛素敏感性、β细胞功能和挑战后血糖：结果：观察到体脂率、瘦体重、胰岛素敏感性和 2 小时血糖发生了显著变化。脂肪量的变化与胰岛素敏感性的变化相关（β = -0.45，p 结论：胰岛素敏感性的变化与脂肪量的变化相关：我们的研究表明，在高风险拉丁裔青年中，脂肪量和瘦肉量的个人内部变化分别与胰岛素敏感性的增加和 2 小时血糖浓度的降低有关。减少区域和器官脂肪沉积对终末期糖尿病风险因素的影响值得进一步研究。

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来源期刊

Pediatric Obesity PEDIATRICS-

CiteScore

7.30

自引率

5.30%

发文量

117

审稿时长

6-12 weeks

期刊介绍： Pediatric Obesity is a peer-reviewed, monthly journal devoted to research into obesity during childhood and adolescence. The topic is currently at the centre of intense interest in the scientific community, and is of increasing concern to health policy-makers and the public at large. Pediatric Obesity has established itself as the leading journal for high quality papers in this field, including, but not limited to, the following: Genetic, molecular, biochemical and physiological aspects of obesity – basic, applied and clinical studies relating to mechanisms of the development of obesity throughout the life course and the consequent effects of obesity on health outcomes Metabolic consequences of child and adolescent obesity Epidemiological and population-based studies of child and adolescent overweight and obesity Measurement and diagnostic issues in assessing child and adolescent adiposity, physical activity and nutrition Clinical management of children and adolescents with obesity including studies of treatment and prevention Co-morbidities linked to child and adolescent obesity – mechanisms, assessment, and treatment Life-cycle factors eg familial, intrauterine and developmental aspects of child and adolescent obesity Nutrition security and the "double burden" of obesity and malnutrition Health promotion strategies around the issues of obesity, nutrition and physical activity in children and adolescents Community and public health measures to prevent overweight and obesity in children and adolescents.