Fabrication of Engineered Drug-Polymer Composite Particles via Piezoelectric Inkjet Technique for Floating Drug Delivery Systems.

IF 3.7 2区 化学 Q2 CHEMISTRY, MULTIDISCIPLINARY Langmuir Pub Date : 2024-11-18 DOI:10.1021/acs.langmuir.4c03556
Hee Jin Kim, Jiye Jang, Jieun Lee, Chang Hun Han, Jin Woong Kim, Bum Jun Park
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Abstract

This study presents a simple approach for fabricating low-density drug-polymer amorphous solid dispersions (ASDs) using a piezoelectric inkjet method, demonstrating potential applications for floating drug delivery systems (FDDS). By adjusting the ratio of two polymers, polylactic acid, and Eudragit RLPO, the floatability and drug release rate of the drug-polymer ASD particles can be easily manipulated. Kinetic model analyses have been conducted to interpret the drug release mechanism. This work offers a robust platform for exploring diverse polymer-drug combinations that are applicable to FDDS.

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来源期刊
Langmuir
Langmuir 化学-材料科学:综合
CiteScore
6.50
自引率
10.30%
发文量
1464
审稿时长
2.1 months
期刊介绍: Langmuir is an interdisciplinary journal publishing articles in the following subject categories: Colloids: surfactants and self-assembly, dispersions, emulsions, foams Interfaces: adsorption, reactions, films, forces Biological Interfaces: biocolloids, biomolecular and biomimetic materials Materials: nano- and mesostructured materials, polymers, gels, liquid crystals Electrochemistry: interfacial charge transfer, charge transport, electrocatalysis, electrokinetic phenomena, bioelectrochemistry Devices and Applications: sensors, fluidics, patterning, catalysis, photonic crystals However, when high-impact, original work is submitted that does not fit within the above categories, decisions to accept or decline such papers will be based on one criteria: What Would Irving Do? Langmuir ranks #2 in citations out of 136 journals in the category of Physical Chemistry with 113,157 total citations. The journal received an Impact Factor of 4.384*. This journal is also indexed in the categories of Materials Science (ranked #1) and Multidisciplinary Chemistry (ranked #5).
期刊最新文献
Electroanalytical Quantification of DNA Chirality. Activation of Carbonyl Groups in Polyimide-Based Covalent Organic Framework with Multiwalled Carbon Nanotubes toward Boosted Pseudocapacitance. Coassembly of Charged Copolymer Amphiphiles Featuring pH-Regulated Antifouling Properties. Fabrication of Engineered Drug-Polymer Composite Particles via Piezoelectric Inkjet Technique for Floating Drug Delivery Systems. Investigation on the Moisture Absorption Behaviors of Palm Leaves (Corypha umbraculifera) and Their Variation Mechanism.
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