Fabrication of Engineered Drug-Polymer Composite Particles via Piezoelectric Inkjet Technique for Floating Drug Delivery Systems.

IF 3.9 2区 化学 Q2 CHEMISTRY, MULTIDISCIPLINARY Langmuir Pub Date : 2024-12-03 Epub Date: 2024-11-18 DOI:10.1021/acs.langmuir.4c03556
Hee Jin Kim, Jiye Jang, Jieun Lee, Chang Hun Han, Jin Woong Kim, Bum Jun Park
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Abstract

This study presents a simple approach for fabricating low-density drug-polymer amorphous solid dispersions (ASDs) using a piezoelectric inkjet method, demonstrating potential applications for floating drug delivery systems (FDDS). By adjusting the ratio of two polymers, polylactic acid, and Eudragit RLPO, the floatability and drug release rate of the drug-polymer ASD particles can be easily manipulated. Kinetic model analyses have been conducted to interpret the drug release mechanism. This work offers a robust platform for exploring diverse polymer-drug combinations that are applicable to FDDS.

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通过压电喷墨技术制造用于浮动给药系统的工程药物-聚合物复合微粒
本研究介绍了一种利用压电喷墨法制造低密度药物聚合物无定形固体分散体(ASD)的简单方法,展示了其在漂浮给药系统(FDDS)中的潜在应用。通过调整聚乳酸和 Eudragit RLPO 这两种聚合物的比例,药物聚合物无定形固体分散体颗粒的漂浮性和药物释放率很容易控制。为解释药物释放机理,还进行了动力学模型分析。这项工作为探索适用于 FDDS 的各种聚合物-药物组合提供了一个强大的平台。
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来源期刊
Langmuir
Langmuir 化学-材料科学:综合
CiteScore
6.50
自引率
10.30%
发文量
1464
审稿时长
2.1 months
期刊介绍: Langmuir is an interdisciplinary journal publishing articles in the following subject categories: Colloids: surfactants and self-assembly, dispersions, emulsions, foams Interfaces: adsorption, reactions, films, forces Biological Interfaces: biocolloids, biomolecular and biomimetic materials Materials: nano- and mesostructured materials, polymers, gels, liquid crystals Electrochemistry: interfacial charge transfer, charge transport, electrocatalysis, electrokinetic phenomena, bioelectrochemistry Devices and Applications: sensors, fluidics, patterning, catalysis, photonic crystals However, when high-impact, original work is submitted that does not fit within the above categories, decisions to accept or decline such papers will be based on one criteria: What Would Irving Do? Langmuir ranks #2 in citations out of 136 journals in the category of Physical Chemistry with 113,157 total citations. The journal received an Impact Factor of 4.384*. This journal is also indexed in the categories of Materials Science (ranked #1) and Multidisciplinary Chemistry (ranked #5).
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