Aedes albopictus is not an arbovirus aficionado when feeding on cynomolgus macaques or squirrel monkeys.

IF 4.6 2区综合性期刊 Q1 MULTIDISCIPLINARY SCIENCES iScience Pub Date : 2024-10-19 eCollection Date: 2024-11-15 DOI:10.1016/j.isci.2024.111198

Hélène Cecilia, Benjamin M Althouse, Sasha R Azar, Brett A Moehn, Ruimei Yun, Shannan L Rossi, Nikos Vasilakis, Kathryn A Hanley

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Abstract

Viruses transmitted by Aedes mosquitoes (e.g., dengue [DENV], Zika [ZIKV]) have demonstrated high potential to spill over from their ancestral, sylvatic cycles in non-human primates to establish transmission in humans. Epidemiological models require accurate knowledge of the contact structure between hosts and vectors, which is highly sensitive to any impacts of virus infection in mosquitoes or hosts on mosquito feeding behavior. Current evidence for whether these viruses affect vector behavior is mixed. Here we leveraged a study on sylvatic DENV-2 and ZIKV transmission between two species of monkey and Aedes albopictus to determine whether virus infection of either host or vector alters vector feeding behavior. Engorgement rates varied from 0% to 100%, but this was not driven by vector nor host infection, but rather by the individual host, host species, and host body temperature. This study highlights the importance of incorporating individual-level heterogeneity of vector biting in arbovirus transmission models.

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白纹伊蚊在捕食猕猴或松鼠猴时并不喜欢感染虫媒病毒。

伊蚊传播的病毒（如登革热[DENV]、寨卡病毒[ZIKV]）已证明极有可能从其祖先在非人类灵长类动物中的传播周期蔓延到人类中。流行病学模型需要准确了解宿主与病媒之间的接触结构，这对蚊子或宿主感染病毒对蚊子觅食行为的影响非常敏感。目前关于这些病毒是否影响病媒行为的证据不一。在这里，我们利用对两种猴子和白纹伊蚊之间的西欧DENV-2和ZIKV传播的研究，来确定病毒感染宿主或载体是否会改变载体的取食行为。啮食率从0%到100%不等，但这不是由病媒或宿主感染驱动的，而是由宿主个体、宿主种类和宿主体温驱动的。这项研究强调了在虫媒病毒传播模型中纳入病媒叮咬个体水平异质性的重要性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

iScience Multidisciplinary-Multidisciplinary

CiteScore

7.20

自引率

1.70%

发文量

1972

审稿时长

6 weeks

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