A Prediction Model for Lymph Node Metastasis of Oral Squamous Cell Carcinoma Based on Multiple Risk Factors

IF 1.7 Q3 DENTISTRY, ORAL SURGERY & MEDICINE Clinical and Experimental Dental Research Pub Date : 2024-11-17 DOI:10.1002/cre2.70046

Hongyu Shen, Tonghan Zhang, Shuoyu Wang

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Abstract

Objectives

Cervical lymph node metastasis (CLNM) frequently occurs in oral cancer patients. This study aims to investigate risk factors associated with CLNM and predict CLNM preoperatively in patients with oral squamous cell carcinoma (OSCC).

Materials and Methods

This population-based, hospital retrospective cohort study included 158 patients with oral cancer. We performed regression analysis to determine risk factors and establish a model for predicting CLNM in patients with OSCC. To distinguish and validate the prediction model, we used the area under the receiver operating characteristic (ROC) curve (AUC).

Results

Lymph node size, tumor size, degree of differentiation, and LVI were risk factors for cancer metastasis. The OR values were 1.245, 2.847, 2.527, and 6.945, respectively. The AUC value for the clinical prediction model was 0.8736 (95% CI: 0.8043–0.9429).

Conclusions

The prediction model for OSCC patients predicts CLNM and provides a new method for preoperative assessment of whether cervical lymph nodes are metastatic, as well as a guide for surgical treatment, including whether to carry out neck dissection and which neck dissection procedure to use.

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基于多种风险因素的口腔鳞状细胞癌淋巴结转移预测模型

目的：颈淋巴结转移（CLNM）经常发生在口腔癌患者中。本研究旨在调查与颈淋巴结转移相关的风险因素，并对口腔鳞状细胞癌（OSCC）患者的颈淋巴结转移进行术前预测：这项基于人群的医院回顾性队列研究纳入了 158 名口腔癌患者。我们进行了回归分析，以确定OSCC患者的风险因素并建立预测CLNM的模型。为了区分和验证预测模型，我们使用了接收者操作特征曲线（ROC）下面积（AUC）：淋巴结大小、肿瘤大小、分化程度和 LVI 是癌症转移的危险因素。OR值分别为1.245、2.847、2.527和6.945。临床预测模型的AUC值为0.8736（95% CI：0.8043-0.9429）：OSCC患者的预测模型可预测CLNM，为术前评估颈部淋巴结是否转移提供了一种新方法，同时也为手术治疗提供了指导，包括是否进行颈部清扫以及采用哪种颈部清扫术。

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来源期刊

Clinical and Experimental Dental Research DENTISTRY, ORAL SURGERY & MEDICINE-

CiteScore

3.30

自引率

5.60%

发文量

165

审稿时长

26 weeks

期刊介绍： Clinical and Experimental Dental Research aims to provide open access peer-reviewed publications of high scientific quality representing original clinical, diagnostic or experimental work within all disciplines and fields of oral medicine and dentistry. The scope of Clinical and Experimental Dental Research comprises original research material on the anatomy, physiology and pathology of oro-facial, oro-pharyngeal and maxillofacial tissues, and functions and dysfunctions within the stomatognathic system, and the epidemiology, aetiology, prevention, diagnosis, prognosis and therapy of diseases and conditions that have an effect on the homeostasis of the mouth, jaws, and closely associated structures, as well as the healing and regeneration and the clinical aspects of replacement of hard and soft tissues with biomaterials, and the rehabilitation of stomatognathic functions. Studies that bring new knowledge on how to advance health on the individual or public health levels, including interactions between oral and general health and ill-health are welcome.