Early-life undernutrition in the great Chinese famine and the risk of early natural menopause: a retrospective cohort study in Western China.

IF 4 2区农林科学 Q2 NUTRITION & DIETETICS Frontiers in Nutrition Pub Date : 2024-11-01 eCollection Date: 2024-01-01 DOI:10.3389/fnut.2024.1432707

Xiaoyang Xu, Yong Zhang, Xiaoya Qi

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Abstract

Purpose: Early age of menopause may increase the risk of fracture, cardiovascular diseases, and all-cause mortality. This study aimed to investigate the relation between early-life undernutrition in the Great Chinese Famine and the risk of early natural menopause.

Methods: A famine exposure retrospective cohort was established during 2017-2018. Postmenopausal women who were born on 01 October 1956-30 September 1964 and came to the hospital for routine health examinations were candidates for the study. Famine time was defined from 1 January 1959 to 31 December 1961. Three types of early-life famine exposure status were determined by the participant's date of birth. Natural menopause age below 45 was defined as early menopause. The association between early-life famine exposure status and the risk of early natural menopause was confirmed by multiple logistic regression.

Result: A total of 3,337 participants born around famine were included in this study. The prevalence of early menopause was 13.1, 10.0, and 8.3% for those born before, during, and after the famine, respectively. The multiple logistic regression showed that women born before famine significantly increased the risk of early menopause compared to non-exposure (born after famine) (the fully adjusted OR = 1.463, 95%CI = 1.049-2.042). The fetal famine exposure did not significantly increase the risk of early menopause (the fully adjusted OR = 1.244, 95%CI = 0.878-1.764).

Conclusion: Long-term early childhood famine exposure, which caused chronic undernutrition at young ages, increased the risk of early menopause. Early lifetime undernutrition can be recognized as an adverse factor in female reproductive development and aging. This cohort study further confirmed the hypothesis of developmental origins of health and disease from the aspect of women's reproductive health. Further mechanism study is warranted.

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中国大饥荒中的早年营养不良与自然绝经提前的风险：一项在中国西部进行的回顾性队列研究。

目的：绝经年龄过早可能会增加骨折、心血管疾病和全因死亡的风险。本研究旨在探讨中国大饥荒早期营养不良与自然绝经年龄提前风险之间的关系：在2017-2018年间建立了一个饥荒暴露回顾性队列。1956年10月1日-1964年9月30日出生并到医院进行常规健康检查的绝经后妇女为研究对象。饥荒时间定义为 1959 年 1 月 1 日至 1961 年 12 月 31 日。根据受试者的出生日期确定三种早期饥荒暴露状况。自然绝经年龄低于 45 岁被定义为早期绝经。多重逻辑回归证实了早期饥荒暴露状况与自然绝经早期风险之间的关联：本研究共纳入了 3337 名出生在饥荒前后的参与者。在饥荒前、饥荒期间和饥荒后出生的人中，提前绝经的发生率分别为 13.1%、10.0% 和 8.3%。多元逻辑回归结果显示，与未接触过饥荒（饥荒后出生）的妇女相比，饥荒前出生的妇女提前绝经的风险明显增加（完全调整后的OR = 1.463，95%CI = 1.049-2.042）。胎儿时期遭受饥荒并不会明显增加更年期提前的风险（完全调整后的OR = 1.244，95%CI = 0.878-1.764）：结论：长期的幼年饥荒会导致幼年时期的慢性营养不良，从而增加更年期提前的风险。早期终生营养不良可被视为女性生殖发育和衰老的不利因素。这项队列研究从女性生殖健康方面进一步证实了健康和疾病起源于发育的假说。有必要开展进一步的机制研究。

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来源期刊

Frontiers in Nutrition Agricultural and Biological Sciences-Food Science

CiteScore

5.20

自引率

8.00%

发文量

2891

审稿时长

12 weeks

期刊介绍： No subject pertains more to human life than nutrition. The aim of Frontiers in Nutrition is to integrate major scientific disciplines in this vast field in order to address the most relevant and pertinent questions and developments. Our ambition is to create an integrated podium based on original research, clinical trials, and contemporary reviews to build a reputable knowledge forum in the domains of human health, dietary behaviors, agronomy & 21st century food science. Through the recognized open-access Frontiers platform we welcome manuscripts to our dedicated sections relating to different areas in the field of nutrition with a focus on human health. Specialty sections in Frontiers in Nutrition include, for example, Clinical Nutrition, Nutrition & Sustainable Diets, Nutrition and Food Science Technology, Nutrition Methodology, Sport & Exercise Nutrition, Food Chemistry, and Nutritional Immunology. Based on the publication of rigorous scientific research, we thrive to achieve a visible impact on the global nutrition agenda addressing the grand challenges of our time, including obesity, malnutrition, hunger, food waste, sustainability and consumer health.