Relationship between HALP and PNI score with 1-month mortality after CABG.

IF 4 2区农林科学 Q2 NUTRITION & DIETETICS Frontiers in Nutrition Pub Date : 2024-11-01 eCollection Date: 2024-01-01 DOI:10.3389/fnut.2024.1489301

Ilhan Koyuncu, Emin Koyun

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Abstract

Background: Coronary heart disease (CHD) is the most common cause of cardiovascular disease (CVD). CHD is among the most common causes of mortality and morbidity world wide. In addition, CHD is one of the most important causes of health expenditures world wide. Today, coronary artery bypass grafting (CABG) operations are a widely used surgical procedure and have an important place in the treatment of CHD. Many scoring systems have been evaluated to estimate the risk of mortality and morbidity. 30-day mortality rates after CABG have been reported as 1-4% in large-scale studies.

Objectives: The aim of our study was to evaluate the relationship between 1-month mortality in patients undergoing CABG and the Hemoglobin, albumin, lymphocyte, platelet index (HALP score) and Prognostic nutritional index (PNI) calculated using laboratory data in the preoperative period.

Methods and design: A total of 239 patients who underwent CABG were evaluated retrospectively. Preoperative biochemical and hemogram values, demographic characteristics, comorbidities, HALP score and PNI values of the patients were recorded. The patients were divided into two groups: Exitus group (n = 51) and survival group (n = 188). The data of the two groups were compared, mainly HALP score and PNI.

Results: It was observed that 51 of 239 patients (21.3%) developed exitus during the 30-day follow-up after CABG. When demographic data are compared; advanced age, female gender, history of DM (Diabetes Mellitus), history of HL (hyperlipidemia) and smoking were found to be associated with mortality. When laboratory data are compared; high troponin levels, low hemoglobin, low lymphocyte and low albumin levels were found to be associated with mortality. Low HALP score (p < 0.001) and low PNI (p < 0.001) were also found to be associated with mortality. In univariate and multivariate regression analysis; advanced age, history of DM, HALP score and PNI were found to be independent predictors of 30-day mortality after CABG. It was determined that a cut-off value of 0.29 for the HALP score and 39.1 for PNI had found, respectively, 81 and 79% sensitivity and 82 and 80% specificity.

Conclusion: Preoperatively measured HALP score and PNI can be used to predict 1-month mortality after CABG.

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HALP 和 PNI 评分与 CABG 术后 1 个月死亡率的关系。

背景：冠心病（CHD）是心血管疾病（CVD）最常见的病因。冠心病是全球最常见的死亡和发病原因之一。此外，冠心病还是造成全球健康支出的最重要原因之一。如今，冠状动脉旁路移植术（CABG）是一种广泛使用的外科手术，在冠心病治疗中占有重要地位。许多评分系统都被用来评估死亡率和发病率风险。在大规模研究中，CABG 术后 30 天的死亡率为 1-4%：我们的研究旨在评估接受 CABG 手术患者的 1 个月死亡率与利用术前实验室数据计算的血红蛋白、白蛋白、淋巴细胞、血小板指数（HALP 评分）和预后营养指数（PNI）之间的关系：对 239 例接受 CABG 的患者进行回顾性评估。记录了患者术前的生化指标和血液图值、人口统计学特征、合并症、HALP 评分和 PNI 值。患者被分为两组：出院组（51 人）和生存组（188 人）。对两组的数据进行比较，主要是 HALP 评分和 PNI：结果显示：239 名患者中有 51 人（21.3%）在 CABG 术后 30 天随访期间出现了出血症。比较人口统计学数据发现，高龄、女性、糖尿病史、高脂血症史和吸烟与死亡率有关。在比较实验室数据时，发现高肌钙蛋白水平、低血红蛋白、低淋巴细胞和低白蛋白水平与死亡率有关。HALP 评分低（p p 结论：术前测量的 HALP 评分和 PNI 可用于预测 CABG 术后 1 个月的死亡率。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Frontiers in Nutrition Agricultural and Biological Sciences-Food Science

CiteScore

5.20

自引率

8.00%

发文量

2891

审稿时长

12 weeks

期刊介绍： No subject pertains more to human life than nutrition. The aim of Frontiers in Nutrition is to integrate major scientific disciplines in this vast field in order to address the most relevant and pertinent questions and developments. Our ambition is to create an integrated podium based on original research, clinical trials, and contemporary reviews to build a reputable knowledge forum in the domains of human health, dietary behaviors, agronomy & 21st century food science. Through the recognized open-access Frontiers platform we welcome manuscripts to our dedicated sections relating to different areas in the field of nutrition with a focus on human health. Specialty sections in Frontiers in Nutrition include, for example, Clinical Nutrition, Nutrition & Sustainable Diets, Nutrition and Food Science Technology, Nutrition Methodology, Sport & Exercise Nutrition, Food Chemistry, and Nutritional Immunology. Based on the publication of rigorous scientific research, we thrive to achieve a visible impact on the global nutrition agenda addressing the grand challenges of our time, including obesity, malnutrition, hunger, food waste, sustainability and consumer health.