Association of matrix metalloproteinases (MMPs) gene polymorphisms with periodontitis: a systematic review.

IF 1.7 Q3 PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH GMS Hygiene and Infection Control Pub Date : 2024-10-23 eCollection Date: 2024-01-01 DOI:10.3205/dgkh000508

Ruchi Pandey, Nandini Gupta, Tripti Jha, Tooba Bint E Manzoor

{"title":"Association of matrix metalloproteinases (MMPs) gene polymorphisms with periodontitis: a systematic review.","authors":"Ruchi Pandey, Nandini Gupta, Tripti Jha, Tooba Bint E Manzoor","doi":"10.3205/dgkh000508","DOIUrl":null,"url":null,"abstract":"Matrix metalloproteinases (MMPs) are proteinases released by gingival cells, macrophages and neutrophils, induced by potentially pathogenic periodontal bacteria of the subgingival plaque, which play a critical role in the pathogenesis of periodontal disease. The expression of MMPs is controlled by chromosome 11. Single nucleotide polymorphisms (SNPs) are linked with variations in the secretion of MMPs, resulting in periodontal disease progression. Genetic studies aim to find the markers for early diagnosis and prevention of the related diseases. This systematic review focuses on finding the association between the MMPs and periodontitis among Indians. A literature review was performed, including studies published between January 1st 2012 and May 2024 were incorporated. This systematic review included 1,046 participants in seven Indian studies, and substantial evidence was found for an association between MMP-9 (-1562C/T) and periodontitis in Indian population.","PeriodicalId":12738,"journal":{"name":"GMS Hygiene and Infection Control","volume":"19 ","pages":"Doc53"},"PeriodicalIF":1.7000,"publicationDate":"2024-10-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11565592/pdf/","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"GMS Hygiene and Infection Control","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.3205/dgkh000508","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2024/1/1 0:00:00","PubModel":"eCollection","JCR":"Q3","JCRName":"PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH","Score":null,"Total":0}

引用次数: 0

Abstract

Matrix metalloproteinases (MMPs) are proteinases released by gingival cells, macrophages and neutrophils, induced by potentially pathogenic periodontal bacteria of the subgingival plaque, which play a critical role in the pathogenesis of periodontal disease. The expression of MMPs is controlled by chromosome 11. Single nucleotide polymorphisms (SNPs) are linked with variations in the secretion of MMPs, resulting in periodontal disease progression. Genetic studies aim to find the markers for early diagnosis and prevention of the related diseases. This systematic review focuses on finding the association between the MMPs and periodontitis among Indians. A literature review was performed, including studies published between January 1^st 2012 and May 2024 were incorporated. This systematic review included 1,046 participants in seven Indian studies, and substantial evidence was found for an association between MMP-9 (-1562C/T) and periodontitis in Indian population.

查看原文

微信好友朋友圈 QQ好友复制链接

本刊更多论文

基质金属蛋白酶（MMPs）基因多态性与牙周炎的关系：系统综述。

基质金属蛋白酶（MMPs）是牙龈细胞、巨噬细胞和中性粒细胞释放的蛋白酶，由龈下牙菌斑中潜在的致病牙周细菌诱导，在牙周病的发病机制中起着关键作用。MMPs 的表达受 11 号染色体控制。单核苷酸多态性（SNPs）与 MMPs 的分泌变化有关，从而导致牙周病的发展。基因研究旨在找到相关疾病早期诊断和预防的标记物。本系统综述的重点是发现印度人的 MMPs 与牙周炎之间的关联。我们进行了文献综述，包括 2012 年 1 月 1 日至 2024 年 5 月期间发表的研究。该系统性综述纳入了七项印度研究中的 1,046 名参与者，发现大量证据表明印度人群中的 MMP-9 (-1562C/T) 与牙周炎存在关联。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文去求助

来源期刊

GMS Hygiene and Infection Control PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH-

自引率

0.00%

发文量

审稿时长

10 weeks