Impact of Age and Comorbid Conditions on Incidence Rates of COVID-19-Associated Hospitalizations, 2020–2021

IF 4.3 4区医学 Q1 INFECTIOUS DISEASES Influenza and Other Respiratory Viruses Pub Date : 2024-11-17 DOI:10.1111/irv.70016

Lisa Saiman, Edward E. Walsh, Angela R. Branche, Angela Barrett, Luis Alba, Sonia Gollerkeri, Julia A. Schillinger, Matthew Phillips, Lyn Finelli

{"title":"Impact of Age and Comorbid Conditions on Incidence Rates of COVID-19-Associated Hospitalizations, 2020–2021","authors":"Lisa Saiman, Edward E. Walsh, Angela R. Branche, Angela Barrett, Luis Alba, Sonia Gollerkeri, Julia A. Schillinger, Matthew Phillips, Lyn Finelli","doi":"10.1111/irv.70016","DOIUrl":null,"url":null,"abstract":"<div>\n \n \n <section>\n \n <h3> Background</h3>\n \n <p>COVID-19-associated hospitalization rates by age and comorbid conditions can more precisely assess risk for severe illness and target prevention and treatment strategies.</p>\n </section>\n \n <section>\n \n <h3> Methods</h3>\n \n <p>We performed a retrospective study to estimate population-based COVID-19-associated hospitalization among patients by age and selected comorbid conditions in three hospital systems in Rochester and New York City (NYC), NY. Incidence rate ratios (IRR) comparing incidence rates for patients with and without these comorbidities were determined.</p>\n </section>\n \n <section>\n \n <h3> Results</h3>\n \n <p>From March 2020 to December 2021, 7779 patients were hospitalized with COVID-19 of whom 43.8% had ≥3 comorbid conditions. Overall annual incidence ranged from 325.3 to 965.8 per 100,000 persons. Age group-specific incidence was lowest in children 10–14 years (range 4.4–58.9) and highest in adults ≥85 years (range 2790.5–5889.6). Incidence rates for comorbid conditions generally increased with increasing age while IRR decreased with increasing age. Children in NYC 5–17 years with asthma or obesity had 3.4 and 53.3 times higher hospitalization rates, respectively, than children without these conditions. Adults in all age groups with obesity, diabetes, coronary artery disease, or congestive heart failure CHF had 1.6–4.7 times, 1.7–7.2 times, 2.0–10.1 times, or 1.7–20.2 times higher hospitalization rates, respectively, than those without these conditions. Adults ≥50 years with asthma had 1.5 to 1.8 times higher hospitalization rates than those without asthma.</p>\n </section>\n \n <section>\n \n <h3> Conclusions</h3>\n \n <p>The burden of hospitalization with COVID-19 was high, particularly among adults ≥85 years and adults with obesity, diabetes, CAD, or CHF. However, the impact of comorbidities was less in older adults. Population-based incidence rates by age and comorbidities provide more precise estimates of the benefits of vaccines and antiviral medications.</p>\n </section>\n </div>","PeriodicalId":13544,"journal":{"name":"Influenza and Other Respiratory Viruses","volume":"18 11","pages":""},"PeriodicalIF":4.3000,"publicationDate":"2024-11-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/irv.70016","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Influenza and Other Respiratory Viruses","FirstCategoryId":"3","ListUrlMain":"https://onlinelibrary.wiley.com/doi/10.1111/irv.70016","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"INFECTIOUS DISEASES","Score":null,"Total":0}

引用次数: 0

Abstract

Background

COVID-19-associated hospitalization rates by age and comorbid conditions can more precisely assess risk for severe illness and target prevention and treatment strategies.

Methods

We performed a retrospective study to estimate population-based COVID-19-associated hospitalization among patients by age and selected comorbid conditions in three hospital systems in Rochester and New York City (NYC), NY. Incidence rate ratios (IRR) comparing incidence rates for patients with and without these comorbidities were determined.

Results

From March 2020 to December 2021, 7779 patients were hospitalized with COVID-19 of whom 43.8% had ≥3 comorbid conditions. Overall annual incidence ranged from 325.3 to 965.8 per 100,000 persons. Age group-specific incidence was lowest in children 10–14 years (range 4.4–58.9) and highest in adults ≥85 years (range 2790.5–5889.6). Incidence rates for comorbid conditions generally increased with increasing age while IRR decreased with increasing age. Children in NYC 5–17 years with asthma or obesity had 3.4 and 53.3 times higher hospitalization rates, respectively, than children without these conditions. Adults in all age groups with obesity, diabetes, coronary artery disease, or congestive heart failure CHF had 1.6–4.7 times, 1.7–7.2 times, 2.0–10.1 times, or 1.7–20.2 times higher hospitalization rates, respectively, than those without these conditions. Adults ≥50 years with asthma had 1.5 to 1.8 times higher hospitalization rates than those without asthma.

Conclusions

The burden of hospitalization with COVID-19 was high, particularly among adults ≥85 years and adults with obesity, diabetes, CAD, or CHF. However, the impact of comorbidities was less in older adults. Population-based incidence rates by age and comorbidities provide more precise estimates of the benefits of vaccines and antiviral medications.

Abstract Image

查看原文

微信好友朋友圈 QQ好友复制链接

本刊更多论文

2020-2021 年年龄和合并症对 COVID-19 相关住院发病率的影响。

背景：按年龄和合并症分类的 COVID-19 相关住院率可以更准确地评估重症风险，并有针对性地制定预防和治疗策略：按年龄和合并症分类的 COVID-19 相关住院率可更准确地评估重症风险，并有针对性地制定预防和治疗策略：方法：我们进行了一项回顾性研究，在纽约州罗切斯特市和纽约市（NYC）的三个医院系统中，按年龄和选定的合并症估算人群中与 COVID-19 相关的住院率。结果显示，从 2020 年 3 月到 2021 年 12 月，COVID-19 患者的住院率将达到 20%：2020年3月至2021年12月，7779名患者因COVID-19住院，其中43.8%的患者合并症≥3种。总体年发病率为每 10 万人 325.3 例至 965.8 例。10-14岁儿童的年龄组发病率最低（范围为4.4-58.9），≥85岁的成年人发病率最高（范围为2790.5-5889.6）。随着年龄的增长，合并症的发病率普遍上升，而IRR则随着年龄的增长而下降。患有哮喘或肥胖症的 5-17 岁《纽约时报》儿童的住院率分别是无哮喘或肥胖症儿童的 3.4 倍和 53.3 倍。患有肥胖症、糖尿病、冠状动脉疾病或充血性心力衰竭（CHF）的各年龄组成人的住院率分别是无上述疾病者的 1.6-4.7 倍、1.7-7.2 倍、2.0-10.1 倍或 1.7-20.2 倍。≥50岁的成人哮喘患者的住院率是非哮喘患者的1.5至1.8倍：COVID-19造成的住院负担很高，尤其是在年龄≥85岁的成年人和患有肥胖症、糖尿病、CAD或心房颤动的成年人中。然而，合并症对老年人的影响较小。按年龄和合并症划分的基于人群的发病率能更精确地估计疫苗和抗病毒药物的益处。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文去求助

来源期刊

Influenza and Other Respiratory Viruses 医学-病毒学

CiteScore

7.20

自引率

4.50%

发文量

120

审稿时长

6-12 weeks

期刊介绍： Influenza and Other Respiratory Viruses is the official journal of the International Society of Influenza and Other Respiratory Virus Diseases - an independent scientific professional society - dedicated to promoting the prevention, detection, treatment, and control of influenza and other respiratory virus diseases. Influenza and Other Respiratory Viruses is an Open Access journal. Copyright on any research article published by Influenza and Other Respiratory Viruses is retained by the author(s). Authors grant Wiley a license to publish the article and identify itself as the original publisher. Authors also grant any third party the right to use the article freely as long as its integrity is maintained and its original authors, citation details and publisher are identified.