{"title":"Constructing Conjugated Polymer Composite Fluorescent Nanodrug Materials for Treating Abdominal Aortic Aneurysm.","authors":"Chao Weng, Yan Xia","doi":"10.1007/s10895-024-04047-3","DOIUrl":null,"url":null,"abstract":"<p><p>The abdominal aortic aneurysm (AAA) is a dilation of the lower part of the body aorta. AAA has no obvious symptoms in the early stages until the aortic wall ruptures suddenly, resulting in massive blood loss and flow into the abdominal cavity. Currently, there is no effective drug treatment for AAA, and the development of effective drugs is crucial. In this study, a novel approach utilizing chitosan/genipin/zinc oxide (CH/G-ZnO) composite nanoparticles as a drug delivery system is proposed. Compound 1 was loaded onto these nanoparticles to form CH/G-ZnO@1 composite. The composite material exhibited light-triggered and rapid gelation properties, and its structure and performance were comprehensively characterized. Subsequently, by treating vascular smooth muscle cells (VSMCs), we found that CH/G-ZnO@1 was able to significantly reduce metalloproteinase (MMP) and increase the expression of COL4A1, thereby increasing the proliferative activity of VSMCs.</p>","PeriodicalId":15800,"journal":{"name":"Journal of Fluorescence","volume":" ","pages":""},"PeriodicalIF":2.6000,"publicationDate":"2024-11-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Fluorescence","FirstCategoryId":"92","ListUrlMain":"https://doi.org/10.1007/s10895-024-04047-3","RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"BIOCHEMICAL RESEARCH METHODS","Score":null,"Total":0}
引用次数: 0
Abstract
The abdominal aortic aneurysm (AAA) is a dilation of the lower part of the body aorta. AAA has no obvious symptoms in the early stages until the aortic wall ruptures suddenly, resulting in massive blood loss and flow into the abdominal cavity. Currently, there is no effective drug treatment for AAA, and the development of effective drugs is crucial. In this study, a novel approach utilizing chitosan/genipin/zinc oxide (CH/G-ZnO) composite nanoparticles as a drug delivery system is proposed. Compound 1 was loaded onto these nanoparticles to form CH/G-ZnO@1 composite. The composite material exhibited light-triggered and rapid gelation properties, and its structure and performance were comprehensively characterized. Subsequently, by treating vascular smooth muscle cells (VSMCs), we found that CH/G-ZnO@1 was able to significantly reduce metalloproteinase (MMP) and increase the expression of COL4A1, thereby increasing the proliferative activity of VSMCs.
期刊介绍：
Journal of Fluorescence is an international forum for the publication of peer-reviewed original articles that advance the practice of this established spectroscopic technique. Topics covered include advances in theory/and or data analysis, studies of the photophysics of aromatic molecules, solvent, and environmental effects, development of stationary or time-resolved measurements, advances in fluorescence microscopy, imaging, photobleaching/recovery measurements, and/or phosphorescence for studies of cell biology, chemical biology and the advanced uses of fluorescence in flow cytometry/analysis, immunology, high throughput screening/drug discovery, DNA sequencing/arrays, genomics and proteomics. Typical applications might include studies of macromolecular dynamics and conformation, intracellular chemistry, and gene expression. The journal also publishes papers that describe the synthesis and characterization of new fluorophores, particularly those displaying unique sensitivities and/or optical properties. In addition to original articles, the Journal also publishes reviews, rapid communications, short communications, letters to the editor, topical news articles, and technical and design notes.
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