{"title":"Crystal structure and the degradation products of Tenvermectin B.","authors":"Zhen-Yu Wang, Chun-Hui Wu, Xiao-Han Ren, Wei Zhang, Shao-Yong Zhang, Huan Qi, Jun Huang, Ji-Dong Wang, Hui Zhang","doi":"10.1080/14786419.2024.2429110","DOIUrl":null,"url":null,"abstract":"<p><p>The purpose of this work was to investigate the crystal structure and degradant products (DPs) of tenvermectin B (TVM B). A suitable crystal of TVM B was obtained from a solvent system (MeOH:formamide:H<sub>2</sub>O = 2:5:2) and its absolute configuration was unambiguously established by single-crystal X-ray diffraction analysis. Meanwhile, a formamide-assisted crystallisation method for the purification of TVM B was developed. During the stress degradation studies of TVM B, four DPs (DPs <b>1</b>-<b>4</b>) were prepared and characterised by MS and NMR. Among them, DP <b>2</b> and DP <b>3</b> have not been reported previously. In addition, the nematocidal activity of these DPs were evaluated.</p>","PeriodicalId":18990,"journal":{"name":"Natural Product Research","volume":" ","pages":"1-7"},"PeriodicalIF":1.9000,"publicationDate":"2024-11-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Natural Product Research","FirstCategoryId":"92","ListUrlMain":"https://doi.org/10.1080/14786419.2024.2429110","RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"CHEMISTRY, APPLIED","Score":null,"Total":0}
引用次数: 0
Abstract
The purpose of this work was to investigate the crystal structure and degradant products (DPs) of tenvermectin B (TVM B). A suitable crystal of TVM B was obtained from a solvent system (MeOH:formamide:H2O = 2:5:2) and its absolute configuration was unambiguously established by single-crystal X-ray diffraction analysis. Meanwhile, a formamide-assisted crystallisation method for the purification of TVM B was developed. During the stress degradation studies of TVM B, four DPs (DPs 1-4) were prepared and characterised by MS and NMR. Among them, DP 2 and DP 3 have not been reported previously. In addition, the nematocidal activity of these DPs were evaluated.
期刊介绍：
The aim of Natural Product Research is to publish important contributions in the field of natural product chemistry. The journal covers all aspects of research in the chemistry and biochemistry of naturally occurring compounds.
The communications include coverage of work on natural substances of land and sea and of plants, microbes and animals. Discussions of structure elucidation, synthesis and experimental biosynthesis of natural products as well as developments of methods in these areas are welcomed in the journal. Finally, research papers in fields on the chemistry-biology boundary, eg. fermentation chemistry, plant tissue culture investigations etc., are accepted into the journal.
Natural Product Research issues will be subtitled either ""Part A - Synthesis and Structure"" or ""Part B - Bioactive Natural Products"". for details on this , see the forthcoming articles section.
All manuscript submissions are subject to initial appraisal by the Editor, and, if found suitable for further consideration, to peer review by independent, anonymous expert referees. All peer review is single blind and submission is online via ScholarOne Manuscripts.
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