Therapeutic potential of resveratrol and autologous chondrocytes in male rat knee joint cartilage repair.

IF 1.9 3区化学 Q3 CHEMISTRY, APPLIED Natural Product Research Pub Date : 2024-11-18 DOI:10.1080/14786419.2024.2429111

Alireza Akhlagh, Aida Iraji, Seyyed Sajad Daneshi, Mehdi Kian, Akram Jamshidzadeh, Shahrokh Zare, Nader Tanideh, Maryam Naseh, Nadiar M Mussin, Madina A Kurmanalina, Amin Tamadon

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Abstract

Osteochondral defects (OCDs) in synovial joints are caused by trauma or inflammatory joint diseases, with no definitive treatment available. This study examined the effects of resveratrol and chondrocyte injections in a rat model of OCD. Twenty-four male Sprague-Dawley rats were divided into four groups: a control group, a resveratrol-only group (10 mg/kg), a chondrocyte-only group (1 × 10⁵ cells), and a combined treatment group that received both treatments. After two months, the rats were euthanized, and their knee joints were analysed histologically and immunohistochemically. The results showed that the combined resveratrol and chondrocyte treatment significantly reduced fibrous tissue, increased cartilage tissue volume, improved cellular distribution, and enhanced the regularity of the articular surface. Collagen types I and II and proteoglycan levels were also elevated. These findings suggest that the combination of resveratrol and chondrocytes has a synergistic effect, promoting effective OCD repair in this rat model, offering potential for future therapeutic approaches.

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白藜芦醇和自体软骨细胞在雄性大鼠膝关节软骨修复中的治疗潜力

滑膜关节的骨软骨缺损（OCD）是由创伤或炎症性关节疾病引起的，目前尚无确切的治疗方法。本研究考察了白藜芦醇和软骨细胞注射对大鼠 OCD 模型的影响。24 只雄性 Sprague-Dawley 大鼠被分为四组：对照组、仅注射白藜芦醇组（10 毫克/千克）、仅注射软骨细胞组（1 × 105 个细胞）和接受两种疗法的联合治疗组。两个月后，大鼠被安乐死，并对其膝关节进行组织学和免疫组化分析。结果显示，白藜芦醇和软骨细胞联合治疗组能显著减少纤维组织，增加软骨组织体积，改善细胞分布，提高关节表面的规则性。I 型和 II 型胶原蛋白以及蛋白多糖的水平也有所提高。这些研究结果表明，白藜芦醇与软骨细胞的结合具有协同作用，可促进该大鼠模型中 OCD 的有效修复，为未来的治疗方法提供了潜力。

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来源期刊

Natural Product Research 化学-医药化学

CiteScore

5.10

自引率

9.10%

发文量

605

审稿时长

2.1 months

期刊介绍： The aim of Natural Product Research is to publish important contributions in the field of natural product chemistry. The journal covers all aspects of research in the chemistry and biochemistry of naturally occurring compounds. The communications include coverage of work on natural substances of land and sea and of plants, microbes and animals. Discussions of structure elucidation, synthesis and experimental biosynthesis of natural products as well as developments of methods in these areas are welcomed in the journal. Finally, research papers in fields on the chemistry-biology boundary, eg. fermentation chemistry, plant tissue culture investigations etc., are accepted into the journal. Natural Product Research issues will be subtitled either ""Part A - Synthesis and Structure"" or ""Part B - Bioactive Natural Products"". for details on this , see the forthcoming articles section. All manuscript submissions are subject to initial appraisal by the Editor, and, if found suitable for further consideration, to peer review by independent, anonymous expert referees. All peer review is single blind and submission is online via ScholarOne Manuscripts.