[Force-Velocity-Endurance (FoVE) Model: a new method for functional striated skeletal muscle in situ evaluation in murine models].

Abstract

The FoVE model is a new theoretical framework coupled with innovative modeling to evaluate the striated skeletal muscle function. The theoretical model is based on two fundamental relationships: the force-velocity relationship and the force-time relationship. These relationships describe the muscle force production capacity as a function of contraction velocity and exercise duration, respectively. By combining them, the FoVE model offers a comprehensive view of the muscle functional capacities at various velocities, with and without fatigue. A unique experimental protocol has been developed using an isokinetic force measurement system to obtain the FoVE parameters of the model. This protocol enables muscle force to be measured at various contraction velocities for a total duration of 3 minutes. Applied to mouse model, the results obtained with the FoVE model show significant differences in the functional capacity of the tibialis anterior muscle. Females have a higher normalized initial maximal force. Conversely, males have a higher initial maximum velocity capacity under fatigue conditions. This approach provides a comprehensive mapping of muscle function, surpassing traditional assessments of isometric strength. It can be applied to basic research in pre-clinical models and translational research in humans.