Sepsis is a potentially life-threatening condition recognized as a global health priority by the World Health Organization. Survivors who develop intensive care unit-acquired weakness (ICUAW) often face long-term motor and functional deficits that significantly impact their quality of life. Although some studies have investigated the mechanisms underlying ICUAW and its long-term effects, much remains unknown. Further research into ICUAW is therefore essential to gain a comprehensive understanding of this phenomenon, which may guide the development of effective treatments to restore patients' quality of life.
{"title":"[Pathophysiology of neuromuscular weakness acquired in intensive care during sepsis].","authors":"Pauline Michel-Flutot, Stéphane Vinit, Arnaud Mansart","doi":"10.1051/medsci/2025024","DOIUrl":"https://doi.org/10.1051/medsci/2025024","url":null,"abstract":"<p><p>Sepsis is a potentially life-threatening condition recognized as a global health priority by the World Health Organization. Survivors who develop intensive care unit-acquired weakness (ICUAW) often face long-term motor and functional deficits that significantly impact their quality of life. Although some studies have investigated the mechanisms underlying ICUAW and its long-term effects, much remains unknown. Further research into ICUAW is therefore essential to gain a comprehensive understanding of this phenomenon, which may guide the development of effective treatments to restore patients' quality of life.</p>","PeriodicalId":18205,"journal":{"name":"M S-medecine Sciences","volume":"41 3","pages":"253-259"},"PeriodicalIF":0.6,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143674368","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-03-01Epub Date: 2025-03-21DOI: 10.1051/medsci/2025026
Rida Al-Rifai, Jean-Rémi Lavillegrand, Alain Tedgui, Hafid Ait-Oufella
{"title":"[Alternating exposure to a high-fat diet aggravates the development of atherosclerosis].","authors":"Rida Al-Rifai, Jean-Rémi Lavillegrand, Alain Tedgui, Hafid Ait-Oufella","doi":"10.1051/medsci/2025026","DOIUrl":"https://doi.org/10.1051/medsci/2025026","url":null,"abstract":"","PeriodicalId":18205,"journal":{"name":"M S-medecine Sciences","volume":"41 3","pages":"213-215"},"PeriodicalIF":0.6,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143674340","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-03-01Epub Date: 2025-03-21DOI: 10.1051/medsci/2025036
Alaedine Benani, Emmanuel Messas
On October 8, 2024, the Nobel Prize in Physics was awarded to John J. Hopfield, professor at Princeton University, and Geoffrey E. Hinton, professor at the University of Toronto, for their "fundamental discoveries that made possible machine learning through artificial neural networks." According to the Nobel committee, John Hopfield designed an associative memory capable of storing and reconstructing images, while Geoffrey Hinton developed a method enabling tasks such as identifying specific elements within images. This article retraces the career paths of these two researchers and highlights their pioneering contributions.
{"title":"[Nobel Prize in physics 2024 : John J. Hopfield and Geoffrey E. Hinton. From Hopfield and Hinton to AlphaFold: The 2024 Nobel Prize honors the pioneers of deep learning].","authors":"Alaedine Benani, Emmanuel Messas","doi":"10.1051/medsci/2025036","DOIUrl":"https://doi.org/10.1051/medsci/2025036","url":null,"abstract":"<p><p>On October 8, 2024, the Nobel Prize in Physics was awarded to John J. Hopfield, professor at Princeton University, and Geoffrey E. Hinton, professor at the University of Toronto, for their \"fundamental discoveries that made possible machine learning through artificial neural networks.\" According to the Nobel committee, John Hopfield designed an associative memory capable of storing and reconstructing images, while Geoffrey Hinton developed a method enabling tasks such as identifying specific elements within images. This article retraces the career paths of these two researchers and highlights their pioneering contributions.</p>","PeriodicalId":18205,"journal":{"name":"M S-medecine Sciences","volume":"41 3","pages":"277-280"},"PeriodicalIF":0.6,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143674366","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-03-01Epub Date: 2025-03-21DOI: 10.1051/medsci/2025022
Manik Bhattacharjee, Thomas Christen, Chantal Delon-Martin, Michel Dojat, Etienne Hugues, Yves Goldberg, Christian Graff, Anne Laurençon, Lydia Oujamaa, Karin Pernet-Gallay, Laurent Vercueil
How does experience outside the present moment become part of living matter? Mental travel, which is both creative and low-carbon, is an experience that anyone can enjoy without needing to abstract from immediacy and project themselves beyond reality. The possibility of such a virtual journey has long fascinated philosophers and then scientists. What does mental travel actually involve? Which neural circuits are engaged? What are the conditions that take us on a hallucinatory journey, deprive us of it, or enable us to control it? What are the adaptive advantages of this imaginary journey? Is it present in other living beings and in our "intelligent" machines?
{"title":"[The shifting territories of mental travel].","authors":"Manik Bhattacharjee, Thomas Christen, Chantal Delon-Martin, Michel Dojat, Etienne Hugues, Yves Goldberg, Christian Graff, Anne Laurençon, Lydia Oujamaa, Karin Pernet-Gallay, Laurent Vercueil","doi":"10.1051/medsci/2025022","DOIUrl":"https://doi.org/10.1051/medsci/2025022","url":null,"abstract":"<p><p>How does experience outside the present moment become part of living matter? Mental travel, which is both creative and low-carbon, is an experience that anyone can enjoy without needing to abstract from immediacy and project themselves beyond reality. The possibility of such a virtual journey has long fascinated philosophers and then scientists. What does mental travel actually involve? Which neural circuits are engaged? What are the conditions that take us on a hallucinatory journey, deprive us of it, or enable us to control it? What are the adaptive advantages of this imaginary journey? Is it present in other living beings and in our \"intelligent\" machines?</p>","PeriodicalId":18205,"journal":{"name":"M S-medecine Sciences","volume":"41 3","pages":"239-245"},"PeriodicalIF":0.6,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143674372","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-03-01Epub Date: 2025-03-21DOI: 10.1051/medsci/2025035
Bertrand Jordan
Using DNA as a storage medium for digital data promises ultra-high density and safe long-term storage. A number of companies are actively working in this space; they have demonstrated the feasibility of the approach and made progress on its implementation. However, speed and cost improvements spanning several orders of magnitude are needed before storage of information on DNA becomes practical.
{"title":"[Progress on DNA information storage].","authors":"Bertrand Jordan","doi":"10.1051/medsci/2025035","DOIUrl":"https://doi.org/10.1051/medsci/2025035","url":null,"abstract":"<p><p>Using DNA as a storage medium for digital data promises ultra-high density and safe long-term storage. A number of companies are actively working in this space; they have demonstrated the feasibility of the approach and made progress on its implementation. However, speed and cost improvements spanning several orders of magnitude are needed before storage of information on DNA becomes practical.</p>","PeriodicalId":18205,"journal":{"name":"M S-medecine Sciences","volume":"41 3","pages":"291-293"},"PeriodicalIF":0.6,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143674369","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-03-01Epub Date: 2025-03-21DOI: 10.1051/medsci/2025032
Pierre G Lutz, Isabelle Lamsoul
{"title":"[Filamins, T helper 2 lymphocytes and asthma : A matter of balance].","authors":"Pierre G Lutz, Isabelle Lamsoul","doi":"10.1051/medsci/2025032","DOIUrl":"https://doi.org/10.1051/medsci/2025032","url":null,"abstract":"","PeriodicalId":18205,"journal":{"name":"M S-medecine Sciences","volume":"41 3","pages":"232-235"},"PeriodicalIF":0.6,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143674362","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-03-01Epub Date: 2025-03-21DOI: 10.1051/medsci/2025029
Milen Milenkov, Laurence Armand-Lefevre
{"title":"[WHO-Tricycle surveillance in Antananarivo (Madagascar) : Circulation of both extended-spectrum β-lactamase producing Escherichia coli strains and plasmids among humans, chickens and the environment].","authors":"Milen Milenkov, Laurence Armand-Lefevre","doi":"10.1051/medsci/2025029","DOIUrl":"https://doi.org/10.1051/medsci/2025029","url":null,"abstract":"","PeriodicalId":18205,"journal":{"name":"M S-medecine Sciences","volume":"41 3","pages":"222-226"},"PeriodicalIF":0.6,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143674373","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-03-01Epub Date: 2025-03-21DOI: 10.1051/medsci/2025034
Joël Coste
{"title":"[Contributions of Mirko Dražen Grmek to the history of medicine and biological science].","authors":"Joël Coste","doi":"10.1051/medsci/2025034","DOIUrl":"https://doi.org/10.1051/medsci/2025034","url":null,"abstract":"","PeriodicalId":18205,"journal":{"name":"M S-medecine Sciences","volume":"41 3","pages":"273-276"},"PeriodicalIF":0.6,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143674348","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Intestinal gluconeogenesis refers to the ability of the gut to produce glucose outside of meals. By initiating a gut-brain neural axis, its activation by dietary fiber or protein improves the regulation of energy balance. Recently, the creation of a genetic activation model of intestinal gluconeogenesis has demonstrated its anti-obesity, anti-diabetes and anti-hepatic steatosis effects. Interestingly, it increases thermogenesis in brown adipose tissue, thereby promoting energy expenditure and contributing to the fight against obesity. Therefore, targeting intestinal gluconeogenesis could be an innovative strategy to address metabolic diseases such as hepatic steatosis and diabetes, paving the way to new therapeutic approaches.
{"title":"[Intestinal gluconeogenesis : When the intestine produces glucose to prevent obesity and hepatic steatosis].","authors":"Justine Vily-Petit, Amandine Gautier-Stein, Gilles Mithieux","doi":"10.1051/medsci/2025023","DOIUrl":"https://doi.org/10.1051/medsci/2025023","url":null,"abstract":"<p><p>Intestinal gluconeogenesis refers to the ability of the gut to produce glucose outside of meals. By initiating a gut-brain neural axis, its activation by dietary fiber or protein improves the regulation of energy balance. Recently, the creation of a genetic activation model of intestinal gluconeogenesis has demonstrated its anti-obesity, anti-diabetes and anti-hepatic steatosis effects. Interestingly, it increases thermogenesis in brown adipose tissue, thereby promoting energy expenditure and contributing to the fight against obesity. Therefore, targeting intestinal gluconeogenesis could be an innovative strategy to address metabolic diseases such as hepatic steatosis and diabetes, paving the way to new therapeutic approaches.</p>","PeriodicalId":18205,"journal":{"name":"M S-medecine Sciences","volume":"41 3","pages":"246-252"},"PeriodicalIF":0.6,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143674364","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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