Application of exosomes for the regeneration of skin wounds: Principles, recent applications and limitations

IF 2.7 4区生物学 Q1 ANATOMY & MORPHOLOGY Tissue & cell Pub Date : 2024-11-10 DOI:10.1016/j.tice.2024.102611

Ali Esmaeili , Ghasem Noorkhajavi , Masoud Soleimani , Hana Farsinezhad , Saeid Bagheri-Mohammadi , Saeed Heidari Keshel

{"title":"Application of exosomes for the regeneration of skin wounds: Principles, recent applications and limitations","authors":"Ali Esmaeili , Ghasem Noorkhajavi , Masoud Soleimani , Hana Farsinezhad , Saeid Bagheri-Mohammadi , Saeed Heidari Keshel","doi":"10.1016/j.tice.2024.102611","DOIUrl":null,"url":null,"abstract":"<div><div>In the medical field, wound healing poses significant challenges due to its complexity and time-consuming nature. Cell-free wound repair, notably the utilization of exosomes (EXOs), has made significant progress in recent years. Urine, saliva, umbilical cord, blood, mesenchymal stem cells and breast milk cells can be used to extract and purify EXOs, which are Nano-sized lipid bilayer vesicles. Besides their relatively little toxicity, non-specific immunogenicity and excellent biocompatibility, EXOs also contain bioactive molecules such as proteins, lipids, microRNAs (miRNAs), and messenger RNAs (mRNAs). Their bioactive compounds have anti-inflammatory properties and can speed up wound healing. Various medicinal agents can also be contained within the EXOs. This review briefly provides new information on the different aspects of EXOs and evaluate the application of EXOs as a promising therapy in the regeneration of skin wounds in recent pre-clinical and clinical studies.</div></div>","PeriodicalId":23201,"journal":{"name":"Tissue & cell","volume":"91 ","pages":"Article 102611"},"PeriodicalIF":2.7000,"publicationDate":"2024-11-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Tissue & cell","FirstCategoryId":"99","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S0040816624003124","RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"ANATOMY & MORPHOLOGY","Score":null,"Total":0}

引用次数: 0

Abstract

In the medical field, wound healing poses significant challenges due to its complexity and time-consuming nature. Cell-free wound repair, notably the utilization of exosomes (EXOs), has made significant progress in recent years. Urine, saliva, umbilical cord, blood, mesenchymal stem cells and breast milk cells can be used to extract and purify EXOs, which are Nano-sized lipid bilayer vesicles. Besides their relatively little toxicity, non-specific immunogenicity and excellent biocompatibility, EXOs also contain bioactive molecules such as proteins, lipids, microRNAs (miRNAs), and messenger RNAs (mRNAs). Their bioactive compounds have anti-inflammatory properties and can speed up wound healing. Various medicinal agents can also be contained within the EXOs. This review briefly provides new information on the different aspects of EXOs and evaluate the application of EXOs as a promising therapy in the regeneration of skin wounds in recent pre-clinical and clinical studies.

查看原文

微信好友朋友圈 QQ好友复制链接

本刊更多论文

外泌体在皮肤伤口再生中的应用：原理、最新应用和局限性。

在医学领域，伤口愈合因其复杂性和耗时长而构成重大挑战。近年来，无细胞伤口修复，特别是利用外泌体（EXOs）取得了重大进展。尿液、唾液、脐带血、血液、间充质干细胞和母乳细胞均可用于提取和纯化外泌体，外泌体是一种纳米级的脂质双层囊泡。EXOs除了具有毒性小、非特异性免疫原性和良好的生物相容性外，还含有生物活性分子，如蛋白质、脂类、微小核糖核酸（miRNA）和信使核糖核酸（mRNA）。它们的生物活性化合物具有抗炎特性，可加快伤口愈合。EXOs中还含有各种药剂。本综述简要介绍了EXOs各方面的新信息，并评估了EXOs作为一种有前景的疗法在最近的临床前和临床研究中对皮肤伤口再生的应用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文去求助

来源期刊

Tissue & cell 医学-解剖学与形态学

CiteScore

3.90

自引率

0.00%

发文量

234

期刊介绍： Tissue and Cell is devoted to original research on the organization of cells, subcellular and extracellular components at all levels, including the grouping and interrelations of cells in tissues and organs. The journal encourages submission of ultrastructural studies that provide novel insights into structure, function and physiology of cells and tissues, in health and disease. Bioengineering and stem cells studies focused on the description of morphological and/or histological data are also welcomed. Studies investigating the effect of compounds and/or substances on structure of cells and tissues are generally outside the scope of this journal. For consideration, studies should contain a clear rationale on the use of (a) given substance(s), have a compelling morphological and structural focus and present novel incremental findings from previous literature.