Association of cardiovascular-kidney-metabolic health and social connection with the risk of depression and anxiety.

IF 5.9 2区医学 Q1 PSYCHIATRY Psychological Medicine Pub Date : 2024-11-18 DOI:10.1017/S0033291724002381

Xinghe Huang, Jie Liang, Junyu Zhang, Jiayi Fu, Wuxiang Xie, Fanfan Zheng

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Abstract

Background: To explore the association of cardiovascular-kidney-metabolic (CKM) health with the risk of depression and anxiety and to investigate the joint association of CKM health and social connection with depression and anxiety.

Methods: This prospective cohort study included 344 956 participants from the UK Biobank. CKM syndrome was identified as a medical condition with the presence of metabolic risk factors, cardiovascular disease, and chronic kidney disease, and was classified into five stages (stage 0-4) in this study. Loneliness and social isolation status were determined by self-reported questionnaires. Cox proportional hazards models were applied for analyses.

Results: Compared with participants in stage 0, the HRs for depression were 1.17 (95% CI 1.10-1.25), 1.40 (95% CI 1.33-1.48), and 2.14 (95% CI 1.98-2.31) for participants in stage 1, 2-3, and 4, respectively. Similarly, participants in stage 2-3 (HR = 1.20, 95% CI 1.14-1.26) and stage 4 (HR = 1.63, 95% CI 1.51-1.75) had greater risks of incident anxiety. We found additive interactions between loneliness and CKM health on the risk of depression and anxiety. Participants simultaneously reported being lonely and in stage 4 had the greatest risk of depression (HR = 4.44, 95% CI 3.89-5.07) and anxiety (HR = 2.58, 95% CI 2.21-3.01) compared with those without loneliness and in stage 0. We also observed an additive interaction between social isolation and CKM health on the risk of depression.

Conclusions: Our findings suggest the importance of comprehensive interventions to improve CKM health and social connection to reduce the disease burden of depression and anxiety.

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心血管-肾脏-代谢健康和社会关系与抑郁和焦虑风险的关系。

背景：目的：探讨心血管-肾脏-代谢（CKM）健康与抑郁和焦虑风险的关系，并研究CKM健康和社会关系与抑郁和焦虑的共同关系：这项前瞻性队列研究包括英国生物库中的 344 956 名参与者。CKM综合征被认定为一种存在代谢风险因素、心血管疾病和慢性肾病的病症，在本研究中被分为五个阶段（0-4期）。孤独感和社会隔离状况由自我报告问卷确定。分析采用 Cox 比例危险模型：与 0 期参与者相比，1、2-3 和 4 期参与者的抑郁 HR 分别为 1.17（95% CI 1.10-1.25）、1.40（95% CI 1.33-1.48）和 2.14（95% CI 1.98-2.31）。同样，处于第 2-3 阶段（HR = 1.20，95% CI 1.14-1.26）和第 4 阶段（HR = 1.63，95% CI 1.51-1.75）的参与者发生焦虑的风险更大。我们发现，孤独感和 CKM 健康状况对抑郁和焦虑的风险有叠加作用。与没有孤独感且处于第 4 阶段的参与者相比，同时报告孤独感且处于第 4 阶段的参与者患抑郁症（HR = 4.44，95% CI 3.89-5.07）和焦虑症（HR = 2.58，95% CI 2.21-3.01）的风险最大。我们还观察到，社会隔离和 CKM 健康状况对抑郁症的风险具有相加作用：我们的研究结果表明，必须采取综合干预措施，改善 CKM 的健康状况和社会联系，以减轻抑郁和焦虑的疾病负担。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Psychological Medicine 医学-精神病学

CiteScore

11.30

自引率

4.30%

发文量

711

审稿时长

3-6 weeks

期刊介绍： Now in its fifth decade of publication, Psychological Medicine is a leading international journal in the fields of psychiatry, related aspects of psychology and basic sciences. From 2014, there are 16 issues a year, each featuring original articles reporting key research being undertaken worldwide, together with shorter editorials by distinguished scholars and an important book review section. The journal''s success is clearly demonstrated by a consistently high impact factor.