The state of lipid metabolism in patients with diabetic nephropathy

Abstract

Aim

This study aimed to evaluate the state of lipid metabolism in patients with diabetic nephropathy.

Methods

In this open label, randomised, prospective study. The study included 120 patients with type 2 diabetes, whose average age was 58.79 ± 1.27 years. In general, the average diabetes experience was 7 ± 3.16 years, HbA1C-9.3 ± 1.82 %, BMI-28.05 ± 3.45. Non-HDL cholesterol levels were calculated (non-HDL cholesterol = total cholesterol - HDL).

Results

As a result of the analysis, a negative relationship of moderate strength was revealed between eGFRcr levels in the blood of TCh (r = -0.32; p < 0.01), triglycerides (r = -0.51; p < 0.018), non-HDL (r = –0.44; p < 0.01) and weak positive association with HDL (r = 0.28; p = 0.01). Negative relationships were also established between the A/Cr index and the blood level of TCh (r = -0.37; p < 0.01), triglycerides (r = –0.42; p < 0.01), non-HDL (r = – 0.35; p < 0.01)/

Conclusion

Therefore, in patients with type 2 diabetes, it is advisable to determine the level of TG in the blood even with reference or slightly elevated levels of TG and non-HDL to predict DN.