Archives of Gerontology and Geriatrics Plus最新文献

Ferritin at admission as a prognostic marker in older adults hospitalized for COVID-19: A retrospective cohort study 入院时铁蛋白作为COVID-19住院老年人的预后标志物：一项回顾性队列研究

Archives of Gerontology and Geriatrics Plus

Pub Date : 2024-12-01 DOI: 10.1016/j.aggp.2024.100105

Janet Ramírez Torres , Ana Luisa Sanchez Arizmendi , César J. Serrano Andrade , Carlos D. Coronado-Alvarado

Background: Older adults remain vulnerable to COVID-19 waves, particularly in low-income countries with health disparities, so the discovery and validation of accessible clinical tools are required. Despite the expected changes associated with aging, little has been studied on ferritinemia as a prognostic marker, specifically in this population. Objective: Evaluate the use of serum ferritin levels at hospital admission as a prognostic marker in older adults hospitalized for COVID-19. Material and methods: This monocentric study included people over 60 hospitalized for COVID-19 between 2021 and 2022. Disease presence was assessed with polymerase chain reaction and ferritin with spectrophotometry. Multiple logistic regression models, as well as ROC and Kaplan-Meier curves, were used. Results: In 239 older adults, the association between serum ferritin and mortality was modified by the presence of clinical severity data at admission, being a poor prognosis factor only for those with severe COVID-19 (OR=2.82, p = 0.028, controlling for age and immunization doses). The best cut-off point was 355 ng/dl (Sensitivity: 88.3 %; Specificity: 27.4 %). However, there were no differences in survival curves. Conclusions: Serum ferritin levels could help guide therapeutic decisions in older adults with severe COVID-19 but do not predict mortality independently.

背景：老年人仍然容易受到COVID-19浪潮的影响，特别是在存在卫生差距的低收入国家，因此需要发现和验证可获得的临床工具。尽管预期与衰老相关的变化，很少研究铁蛋白血症作为预后标志物，特别是在这一人群中。目的：评价入院时血清铁蛋白水平作为COVID-19住院老年人预后指标的作用。材料和方法：这项单中心研究包括了在2021年至2022年期间因COVID-19住院的60岁以上的人。用聚合酶链反应和铁蛋白分光光度法评估疾病的存在。采用多元logistic回归模型、ROC曲线和Kaplan-Meier曲线。结果：239例老年人中，血清铁蛋白与死亡率之间的相关性因入院时临床严重程度数据的存在而被修正，仅在重症COVID-19患者中成为不良预后因素（OR=2.82, p = 0.028，控制年龄和免疫剂量）。最佳临界值为355 ng/dl(灵敏度：88.3%；特异性：27.4%)。然而，在生存曲线上没有差异。结论：血清铁蛋白水平可以帮助指导老年重症COVID-19患者的治疗决策，但不能独立预测死亡率。

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引用次数: 0

Dance programme for older adults with pre-frailty: A mixed-methods feasibility study 舞蹈节目为老年人与前期虚弱：一个混合方法的可行性研究

Archives of Gerontology and Geriatrics Plus

Pub Date : 2024-12-01 DOI: 10.1016/j.aggp.2024.100104

Tianma Xu, Vivian Soo, Hui Yi Clara Chang, Maegan Leong, Nur Haidi Hakim Bin Mahmod, Jing Shi

The prevalence of older adults with frailty and pre-frailty is increasing with the rapidly ageing population in Singapore. This study aimed to evaluate the feasibility of a 12-week Dance-Up program and test its effects on the physical and psychosocial well-being of older adults with pre-frailty in the community setting in Singapore. A mixed-method approach was used. Pre-post assessments in physical and mobility functions, fear of falling, pain and goal achievements were statistically analysed to detect any changes. Participants’ attendance, drop-out rate, and perception of the program via semi-structured interviews were gathered post-intervention to determine its feasibility. Thirteen eligible participants (mean age: 78.7 years) with mild frailty (Clinical Frailty Scale scored 3 and 4) enrolled in the program and nine completed the 12-week intervention. The majority (n = 8) were female. The average attendance rate was 83 %. Only some assessment tools (e.g. Dynamic Gait Index, Goal Attainment Scale) were sensitive to detect changes pre-/post-intervention. Thematic analysis of the interviews revealed: 1) the acceptance of the program among participants; 2) both positive factors (e.g. self-belief of the importance of regular dance practice) and negative factors (e.g. functional limitations and other commitments) may have influenced the program's outcomes. Participants provided recommendations for future implementation. The Dance-up programme was well received by participants but requires fine-tuning and other assessment tools should be explored in future studies.

随着新加坡人口的迅速老龄化，老年人体弱和体弱前期的患病率正在增加。本研究旨在评估一项为期12周的Dance-Up项目的可行性，并测试其对新加坡社区中身体虚弱的老年人的身体和心理健康的影响。采用混合方法。对身体和活动功能、对摔倒的恐惧、疼痛和目标实现的前后评估进行统计分析，以发现任何变化。干预后，通过半结构化访谈收集参与者的出勤率、辍学率和对该计划的看法，以确定其可行性。13名轻度虚弱（临床虚弱量表评分为3分和4分）的符合条件的参与者（平均年龄：78.7岁）参加了该计划，其中9名完成了为期12周的干预。大多数（n = 8）为女性。平均出勤率为83%。只有一些评估工具（如动态步态指数，目标实现量表）对检测干预前后的变化敏感。访谈的专题分析揭示：1)参与者对节目的接受程度；2)积极因素（如对定期舞蹈练习重要性的自信）和消极因素（如功能限制和其他承诺）都可能影响项目的结果。与会者提出了今后执行的建议。Dance-up计划受到参与者的欢迎，但需要进行微调，在未来的研究中应探讨其他评估工具。

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引用次数: 0

Impact of dual caregiving on well-being and loneliness among ever-married women in Japan: A pre- and post-COVID-19 pandemic comparison 双重照顾对日本已婚女性幸福感和孤独感的影响：covid -19大流行前后的比较

Archives of Gerontology and Geriatrics Plus

Pub Date : 2024-12-01 DOI: 10.1016/j.aggp.2024.100101

Makiko Kawabe , Yoko Moriyama , Takehiro Sugiyama , Nanako Tamiya

Background

The COVID-19 pandemic has significantly impacted people involved in a combination of childcare and elderly care (dual caregivers). As their number is expected to rise in some countries, there remains limited research on the impact of the pandemic on their well-being and loneliness.

Methods

We utilized repeated cross-sectional data from a large internet survey conducted between 2019 and 2021 to examine the association between informal caregiving status (no care, childcare only, elderly care only, and dual care) and the deterioration of well-being and loneliness among married women aged 20–59.

Results

In 2019, the total sample size was 7,357 (60 dual care, 3,630 elderly care only, 3,470 childcare only, and 3,197 no care). In 2021, the sample comprised 6,645 (77 dual care, 3,164 elderly care only, 148 childcare only, and 3,256 no care). In 2019, the adjusted odds ratio (95 % confidence interval [CI]) for lower well-being and higher loneliness in informal caregiving statuses (childcare only, elderly care only, and dual care) compared to no care was 1.38 (1.03–1.86), significant only for elderly care only. In 2021, elderly care only remained significant, with an odds ratio of 1.84 (1.15–2.97), while dual care was associated with lower well-being (1.55 (1.11–2.20) and higher loneliness (2.08 (1.24–3.49).

Conclusions

Our study found that dual caregivers experienced greater declines in well-being and increased loneliness following the pandemic than non-caregivers. This highlights the importance of enhancing support for dual caregivers during current and future crises to prevent worsening well-being and loneliness.

COVID-19大流行对儿童保育和老年人护理（双重照顾者）的人产生了重大影响。由于在一些国家，这一数字预计会上升，但关于这一流行病对他们的福祉和孤独感的影响的研究仍然有限。方法利用2019年至2021年进行的一项大型网络调查的重复横断面数据，研究20-59岁已婚女性的非正式照顾状况（无照顾、只照顾儿童、只照顾老人和双重照顾）与幸福感恶化和孤独感之间的关系。结果2019年，总样本量为7357人，其中双重护理60人、老年护理3630人、托儿护理3470人、无护理3197人。到2021年，样本包括6645个（77个双重护理，3164个只照顾老人，148个只照顾儿童，3256个不照顾）。2019年，与没有护理相比，非正式护理状态（仅托儿、仅老年人护理和双重护理）较低的幸福感和较高的孤独感的调整优势比（95%置信区间[CI]）为1.38(1.03-1.86)，仅在老年人护理中具有显著性。2021年，只有老年人护理仍然显著，比值比为1.84(1.15-2.97)，而双重护理与较低的幸福感(1.55（1.11-2.20）和较高的孤独感(2.08（1.24-3.49）相关。一项研究发现，与非照顾者相比，双重照顾者在大流行后幸福感下降幅度更大，孤独感增加。这突出了在当前和未来危机期间加强对双重照顾者的支持的重要性，以防止福祉和孤独感恶化。

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引用次数: 0

Negative attitudes toward the majority and perceived hostile and modern prejudices: Focus on older adults and people with disabilities 对大多数人的消极态度以及被认为具有敌意的现代偏见：关注老年人和残疾人

Archives of Gerontology and Geriatrics Plus

Pub Date : 2024-11-19 DOI: 10.1016/j.aggp.2024.100102

Yuho Shimizu

With the growing emphasis on diversity in recent years, we need to form a society wherein older adults and people with disabilities can play active roles together with younger and able-bodied people. However, hostile and modern prejudices against older adults and people with disabilities have inhibited their participation in society. This study examined the association between perceived prejudices against older adults and people with disabilities and their attitudes toward younger and able-bodied people. We administered an online survey to 503 older adults (aged 65–97, M = 74.08 years; 267 women) and 518 people with disabilities (aged 18–64, M = 40.25 years; 180 women). The results showed that older adults (people with disabilities) with more perceived hostile and modern prejudices had more negative attitudes toward younger (able-bodied) people.

近年来，随着对多元化的日益重视，我们需要建立一个老年人和残疾人能够与年轻人和健全人一起发挥积极作用的社会。然而，对老年人和残疾人的敌意和现代偏见阻碍了他们参与社会。本研究探讨了对老年人和残疾人的偏见与他们对年轻人和健全人的态度之间的关系。我们对 503 名老年人（65-97 岁，男 = 74.08 岁；女 267 人）和 518 名残疾人（18-64 岁，男 = 40.25 岁；女 180 人）进行了在线调查。结果表明，老年人（残疾人）对年轻人（健全人）的敌对和现代偏见感知较强，他们对年轻人（健全人）的负面态度也较强。

引用次数: 0

Cognitive decline gap between male and female in Indian context: Examining the contribution of underlying factors using non-linear decomposition analysis 印度男女认知能力下降的差距：利用非线性分解分析法研究潜在因素的作用

Archives of Gerontology and Geriatrics Plus

Pub Date : 2024-11-16 DOI: 10.1016/j.aggp.2024.100103

Subhadeep Saha, Priya Das, Tanu Das, Partha Das, Tamal Basu Roy

Background

Cognitive decline denotes the condition of having memory loss, reduced or slower thinking skills. It is an alarming issue with the increasing age of individuals and sometimes it hinders the smooth functioning of daily activities in life. Affirmations from both developed and developing countries manifest that older people are at risk of cognitive decline; however, the study about male-female differential remained scanty. So, the study examines gender-specific differences in cognitive decline among middle-aged and older adults by identifying the significant covariates responsible for the change in cognitive decline through the FDA.

Methods

The study used information collected from 52,569 participants (females 26,665 and males 25,904) aged 45 years and above from the latest cross-sectional dataset of LASI. Descriptive statistics, multivariable logistic regression, and FDA techniques were utilized.

Results

Multivariable logistic regression revealed that female individuals had 1.90 times [95% CI: (1.77-2.05)] higher odds of cognitive decline than male individuals. In addition, the FDA revealed that school attainment alone was found enough to narrate the difference in the pervasiveness of cognitive decline among individuals between males and females by 54.75%. Marital status, working status, and reading habits were found to express a profound impact on the male-female gap in the prevalence of cognitive decline by 9.41%, 6.47%, and 12.25% respectively.

Conclusions

Findings suggest that there is a need for comprehensive public service intervention like community healthcare and formulation of various health programs to address the cognitive decline, more so for female individuals without neglecting the male ones.

背景认知功能衰退是指记忆力减退、思维能力下降或迟钝。随着年龄的增长，认知能力下降是一个令人担忧的问题，有时会妨碍日常生活的顺利进行。发达国家和发展中国家的研究都表明，老年人有认知能力下降的风险；然而，关于男女差异的研究仍然很少。因此，本研究通过确定导致中老年人认知能力下降变化的重要协变量，研究了中老年人认知能力下降的性别差异。结果多变量逻辑回归显示，女性认知能力下降的几率是男性的 1.90 倍 [95% CI：(1.77-2.05)]。此外，FDA 还发现，仅学校教育程度一项就足以说明男性和女性在认知能力下降的普遍程度上存在 54.75% 的差异。结论研究结果表明，有必要采取全面的公共服务干预措施，如社区医疗保健和制定各种健康计划，以解决认知能力下降问题，尤其是在不忽视男性的情况下解决女性认知能力下降问题。

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引用次数: 0

Do healthy older adults use SNS? Focus on LINE, Facebook, Twitter (now X), and Instagram 健康的老年人使用 SNS 吗？关注 LINE、Facebook、Twitter（现为 X）和 Instagram

Archives of Gerontology and Geriatrics Plus

Pub Date : 2024-11-14 DOI: 10.1016/j.aggp.2024.100096

Kanon Tsukada , Tomoya Takahashi , Yuho Shimizu , Yan Li , Toshihito Tsuchiya , Kiyo Kawakubo , Tomoya Sagara , Koki Ito , Tomoki Furuya , Hiroyuki Suzuki

Background

The use of social networking services (SNS) by older adults within the context of the digital divide has become a hot topic. Several studies have shown that SNS use among older adults is related to their health status; however, few studies have examined the association between health and specific SNS platforms.

Objective

This study investigates the relationship between older adults’ use of four major SNS platforms in Japan (LINE, Facebook, Twitter [now X], and Instagram) and the health of older adults. Subjective health and frequency of going out were used as health indicators. Method: A survey was conducted among participants in a health promotion program for older adults in Tokyo between 2020 and 2022. A total of 391 older adults participated in the study (M = 72.11 years, 65–86 years, 363 women).

Results

Logistic regression analysis revealed that subjective health was higher in users of Facebook, Twitter [now X], and Instagram (but not LINE) compared to non-users. Frequency of going out was not associated with SNS use.

Conclusions

Older adults with higher subjective health may be more likely to use SNS platforms due to their willingness to learn new skills and actively participate in social activities. Additionally, SNS may help improve the health of older adults by enabling communication with distant family and friends, even for those who are unable to go out frequently due to health problems.

背景老年人在数字鸿沟背景下使用社交网络服务（SNS）已成为一个热门话题。本研究调查了日本老年人使用四种主要 SNS 平台（LINE、Facebook、Twitter [现在的 X] 和 Instagram）与老年人健康之间的关系。以主观健康状况和外出频率作为健康指标。调查方法在 2020 年至 2022 年期间，对东京老年人健康促进计划的参与者进行了调查。结果逻辑回归分析表明，Facebook、Twitter [now X] 和 Instagram（但不包括 LINE）用户的主观健康状况高于非用户。结论主观健康状况较好的老年人可能更倾向于使用 SNS 平台，因为他们愿意学习新技能并积极参与社交活动。此外，即使是那些因健康问题而无法经常外出的老年人，也可以通过 SNS 与远方的家人和朋友进行交流，从而帮助改善老年人的健康状况。

{"title":"Do healthy older adults use SNS? Focus on LINE, Facebook, Twitter (now X), and Instagram","authors":"Kanon Tsukada , Tomoya Takahashi , Yuho Shimizu , Yan Li , Toshihito Tsuchiya , Kiyo Kawakubo , Tomoya Sagara , Koki Ito , Tomoki Furuya , Hiroyuki Suzuki","doi":"10.1016/j.aggp.2024.100096","DOIUrl":"10.1016/j.aggp.2024.100096","url":null,"abstract":"<div><h3>Background</h3><div>The use of social networking services (SNS) by older adults within the context of the digital divide has become a hot topic. Several studies have shown that SNS use among older adults is related to their health status; however, few studies have examined the association between health and specific SNS platforms.</div></div><div><h3>Objective</h3><div>This study investigates the relationship between older adults’ use of four major SNS platforms in Japan (LINE, Facebook, Twitter [now X], and Instagram) and the health of older adults. Subjective health and frequency of going out were used as health indicators. Method: A survey was conducted among participants in a health promotion program for older adults in Tokyo between 2020 and 2022. A total of 391 older adults participated in the study (<em>M</em> = 72.11 years, 65–86 years, 363 women).</div></div><div><h3>Results</h3><div>Logistic regression analysis revealed that subjective health was higher in users of Facebook, Twitter [now X], and Instagram (but not LINE) compared to non-users. Frequency of going out was not associated with SNS use.</div></div><div><h3>Conclusions</h3><div>Older adults with higher subjective health may be more likely to use SNS platforms due to their willingness to learn new skills and actively participate in social activities. Additionally, SNS may help improve the health of older adults by enabling communication with distant family and friends, even for those who are unable to go out frequently due to health problems.</div></div>","PeriodicalId":100119,"journal":{"name":"Archives of Gerontology and Geriatrics Plus","volume":"1 4","pages":"Article 100096"},"PeriodicalIF":0.0,"publicationDate":"2024-11-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142704803","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

“There's a lot of factors”: Researcher reflections on using I-poetry to empathetically understand vaccine hesitant individuals "因素很多"：研究人员对使用 I- 诗歌以感同身受的方式理解疫苗接种犹豫者的思考

Archives of Gerontology and Geriatrics Plus

Pub Date : 2024-11-12 DOI: 10.1016/j.aggp.2024.100100

Bryce Van Vleet M.S. , Heather R. Fuller Ph.D. , Andrea Huseth-Zosel Ph.D.

Background

Despite higher vaccination rates compared to other age groups, many US older adults remain under-vaccinated against preventable diseases leading to increased risk of serious illness, hospitalization, or death posed from disease. This study investigates the underlying reasons for older adults not getting vaccinated.

Methods

From a larger interview study conducted in North Dakota, eight older adults (Mean Age = 73) were identified as being vaccine hesitant. Participants were asked, “How do you decide about whether or not to get a specific vaccine?” Then, participants' responses were analyzed using the I-poetry qualitative methodology, which involves creating a poem from interview transcripts to capture the essence of participants' experiences.

Results

Poetic findings clarify interacting sources of immunization unease and highlight potential intervention avenues for medical professionals. Specifically, the poetic analysis revealed themes of mistrust in the healthcare system, preference for natural immunity, and concerns about vaccine side effects. The study suggests that healthcare professionals should consider using empathetic communication strategies to address vaccine hesitancy in older adults.

Conclusions

Understanding vaccine hesitancy as a tapestry instead of individual factors may be more useful for older adults who culminate their hesitant beliefs from prior life experiences. Additionally, to improve trust in healthcare providers, it is suggested that more first-person narratives of older adult experiences are used and solicited by healthcare providers. Possible interventions are discussed.

背景尽管与其他年龄组相比，美国老年人的疫苗接种率较高，但许多老年人对可预防疾病的疫苗接种仍然不足，导致他们患重病、住院或因病死亡的风险增加。本研究调查了老年人不接种疫苗的根本原因。方法在北达科他州进行的一项规模较大的访谈研究中，8 名老年人（平均年龄 = 73 岁）被确认为疫苗接种犹豫不决者。参与者被问到："您如何决定是否接种特定疫苗？然后，使用 I-poetry 定性分析方法对参与者的回答进行分析，该方法包括从访谈记录中创作一首诗，以捕捉参与者经历的精髓。结果诗歌研究结果澄清了免疫接种不安的互动来源，并强调了医疗专业人员的潜在干预途径。具体来说，诗歌分析揭示了对医疗系统的不信任、对自然免疫的偏好以及对疫苗副作用的担忧等主题。研究表明，医疗保健专业人员应考虑使用移情沟通策略来解决老年人的疫苗犹豫不决问题。结论将疫苗犹豫不决理解为一种织锦，而不是个别因素，可能对那些从以前的生活经历中总结出犹豫信念的老年人更有用。此外，为了提高对医疗服务提供者的信任，建议医疗服务提供者使用和征求更多老年人的第一人称叙述。本文还讨论了可能的干预措施。

{"title":"“There's a lot of factors”: Researcher reflections on using I-poetry to empathetically understand vaccine hesitant individuals","authors":"Bryce Van Vleet M.S. , Heather R. Fuller Ph.D. , Andrea Huseth-Zosel Ph.D.","doi":"10.1016/j.aggp.2024.100100","DOIUrl":"10.1016/j.aggp.2024.100100","url":null,"abstract":"<div><h3>Background</h3><div>Despite higher vaccination rates compared to other age groups, many US older adults remain under-vaccinated against preventable diseases leading to increased risk of serious illness, hospitalization, or death posed from disease. This study investigates the underlying reasons for older adults not getting vaccinated.</div></div><div><h3>Methods</h3><div>From a larger interview study conducted in North Dakota, eight older adults (Mean Age = 73) were identified as being vaccine hesitant. Participants were asked, “How do you decide about whether or not to get a specific vaccine?” Then, participants' responses were analyzed using the I-poetry qualitative methodology, which involves creating a poem from interview transcripts to capture the essence of participants' experiences.</div></div><div><h3>Results</h3><div>Poetic findings clarify interacting sources of immunization unease and highlight potential intervention avenues for medical professionals. Specifically, the poetic analysis revealed themes of mistrust in the healthcare system, preference for natural immunity, and concerns about vaccine side effects. The study suggests that healthcare professionals should consider using empathetic communication strategies to address vaccine hesitancy in older adults.</div></div><div><h3>Conclusions</h3><div>Understanding vaccine hesitancy as a tapestry instead of individual factors may be more useful for older adults who culminate their hesitant beliefs from prior life experiences. Additionally, to improve trust in healthcare providers, it is suggested that more first-person narratives of older adult experiences are used and solicited by healthcare providers. Possible interventions are discussed.</div></div>","PeriodicalId":100119,"journal":{"name":"Archives of Gerontology and Geriatrics Plus","volume":"1 4","pages":"Article 100100"},"PeriodicalIF":0.0,"publicationDate":"2024-11-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142651605","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The link between periodontitis and Alzheimer's disease – Brunei context 牙周炎与阿尔茨海默病之间的联系 - 文莱背景

Archives of Gerontology and Geriatrics Plus

Pub Date : 2024-11-12 DOI: 10.1016/j.aggp.2024.100097

Sarah Nabihah Mohamad Fadzli , Jagjit Singh Dhaliwal , Faiza Alam , Jacqueline Kamaluddin , Hanif Abdul Rahman

Aim

The study aims to explore the relationship between periodontitis and Alzheimer's disease, focusing on the association and their potential impact on cognitive health.

Methods

A retrospective study was conducted utilizing data obtained from the Brunei Health Information Management System (Bru-HIMS). The research study examined the correlation between periodontitis and Alzheimer's disease in individuals admitted to government healthcare settings between January 2014 and December 2023. Logistic regression and survival analysis were applied.

Results

After diagnosis of periodontitis, 81.6 %, 59.2 % and 40.8 % developed Alzheimer's disease after 1–3- and 5-years, respectively. Women (34.3 %) had significantly lower proportion of developing Alzheimer's disease after 5 years compared to men (46.3 %). Furthermore, those with history of tooth extraction has a high risk of developing Alzheimer's disease (Adjusted Hazard Ratio = 5.00; 95 % CI: 2.04, 12.28; p < 0.001).

Conclusion

The study highlights the importance of understanding periodontal health in Alzheimer's patients and suggests further research and targeted interventions to mitigate its impact on cognitive function.

目的本研究旨在探讨牙周炎与阿尔茨海默病之间的关系，重点关注两者之间的关联及其对认知健康的潜在影响。方法本研究利用从文莱卫生信息管理系统（Bru-HIMS）中获取的数据开展了一项回顾性研究。研究调查了2014年1月至2023年12月期间政府医疗机构收治的牙周炎患者与阿尔茨海默病之间的相关性。结果确诊牙周炎后，分别有 81.6%、59.2% 和 40.8%的人在 1-3 年和 5 年后患上阿尔茨海默病。与男性（46.3%）相比，女性（34.3%）5 年后罹患阿尔茨海默病的比例明显较低。此外，有拔牙史的人罹患阿尔茨海默病的风险较高（调整危险比 = 5.00; 95 % CI: 2.04, 12.28; p < 0.001）。

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引用次数: 0

Spirituality, forgiveness and self-esteem throughout adulthood in France 法国成年期的精神、宽恕和自尊

Archives of Gerontology and Geriatrics Plus

Pub Date : 2024-11-09 DOI: 10.1016/j.aggp.2024.100098

Agli Océane , Bailly Nathalie , Cuervo-Lombard Christine-Vanessa

Purpose

It appears that spirituality, forgiveness, and self-esteem are important values which transcend human actions. This transversal study aims to observe spirituality, forgiveness, and self-esteem during aging.

Methods

A quantitative protocol was conducted with 206 participants divided into two groups: younger adults (M = 23.05 years old) and older people (M = 73.09 years old). Three tests measured spirituality, forgiveness and self-esteem.

Principal results

Results showed that older people have higher scores than younger adults in spirituality (peace dimension), forgiveness (transcendence and emotional factors) and self-esteem. Moreover, all dimensions of spirituality (peace, mean, faith) were correlated with the transcendence and emotional factors of forgiveness and with self-esteem during aging.

Major conclusion

It seems that with age, individuals have a better self-esteem linked to more pronounced spiritual needs (sense of peace, meaning of life, faith) and manage to forgive more unconditionally with less resentment than younger people.

目的精神、宽恕和自尊似乎是超越人类行为的重要价值观。本横向研究旨在观察老龄化过程中的灵性、宽恕和自尊。方法将 206 名参与者分为两组：年轻成年人（男 = 23.05 岁）和老年人（男 = 73.09 岁）。主要结果结果显示，老年人在灵性（和平维度）、宽恕（超越和情感因素）和自尊方面的得分高于年轻人。主要结论随着年龄的增长，个人的自尊似乎与更明显的精神需求（和平感、生命意义、信仰）有关，并且能够比年轻人更无条件地宽恕他人，怨恨更少。

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引用次数: 0

Circulating miR-323–3p as a novel potential plasma biomarker for multimorbidity burden and cognitive decline in middle-aged and older adults: Results from the national institute for longevity sciences–longitudinal study of aging in Japan 循环 miR-323-3p 作为中老年人多病负担和认知能力下降的潜在新型血浆生物标记物：日本国立长寿科学研究所老龄化纵向研究的结果

Archives of Gerontology and Geriatrics Plus

Pub Date : 2024-11-07 DOI: 10.1016/j.aggp.2024.100099

Wei-Min Chu , Mio Goto , Keiko Kabetani , Yukiko Nishita , Shu Zhang , Hiroshi Shimokata , Meng-Chih Lee , Akiko Satoh , Rei Otsuka

Background

Several circulating microRNAs (miRNAs) in the blood are indicators of chronic diseases, but their association with multimorbidity burden is unknown. The aim of this study was to assess the association of plasma levels of circulating miR-323–3p and miR-135–3p with age, cognitive performance, and number of comorbidities in middle-aged and older individuals.

Methods

Data from 295 community dwellers (≥40 years) who participated in the second wave (2000‒2002) of the National Institute for Longevity Sciences-Longitudinal Study of Aging in Japan were analyzed. miRNAs were isolated from the plasma, and miR-323–3p and miR-135–3p levels were measured using quantitative reverse-transcription polymerase chain reaction and normalized, with miR-16 as an endogenous reference gene. Cognitive performance was assessed using the Information and Similarities subtests and the Digit Symbol Substitution Test of the Wechsler Adult Intelligence Scale-Revised Short Form (WAIS-R-SF). Correlation tests and multivariate general linear regression analyses were performed to examine the relationship among circulating miRNA levels, burden of multimorbidity, and cognitive performance.

Results

The mean age of the participants was 59.15 ± 10.26 years. Pearson's correlation analysis revealed that the miR-323–3p level positively correlated with age and number of comorbidities but negatively correlated with WAIS-R-SF subtest performance. In men, miR-323–3p level negatively correlated with the performance of all three WAIS-R-SF subtests. The general linear regression analysis showed that the miR-323–3p level increased in participants with four comorbidities compared with those with one comorbidity.

Conclusion

Circulating miR-323–3p level is associated with the burden of multimorbidity and decreased cognitive performance in middle-aged and older adults.

背景血液中的几种循环微RNA（miRNA）是慢性疾病的指标，但它们与多病负担的关系尚不清楚。本研究旨在评估中老年人血浆中循环 miR-323-3p 和 miR-135-3p 的水平与年龄、认知能力和合并症数量的关系。从血浆中分离出 miRNA，用定量反转录聚合酶链反应法测定 miR-323-3p 和 miR-135-3p 的水平，并以 miR-16 作为内源性参考基因进行归一化处理。认知能力采用韦氏成人智能量表-修订简表（WAIS-R-SF）的信息和相似性分测验和数字符号替换测验进行评估。研究人员进行了相关性检验和多变量一般线性回归分析，以探讨循环 miRNA 水平、多病负担和认知能力之间的关系。皮尔逊相关分析表明，miR-323-3p水平与年龄和合并症数量呈正相关，但与WAIS-R-SF分测验成绩呈负相关。在男性中，miR-323-3p 水平与 WAIS-R-SF 所有三个分测验的成绩呈负相关。一般线性回归分析表明，与患有一种疾病的人相比，患有四种疾病的人的 miR-323-3p 水平会升高。

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引用次数: 0