Autophagy in reproduction and pregnancy-associated diseases

IF 4.6 2区综合性期刊 Q1 MULTIDISCIPLINARY SCIENCES iScience Pub Date : 2024-10-28 DOI:10.1016/j.isci.2024.111268

Asmita Singh , Maira L. Perez , Oleksandr Kirsanov , Elizabeth Padilla-Banks , Carlos M. Guardia

引用次数: 0

Abstract

As advantageous as sexual reproduction is during progeny generation, it is also an expensive and treacherous reproductive strategy. The viviparous eukaryote has evolved to survive stress before, during, and after pregnancy. An important and conserved intracellular pathway for the control of metabolic stress is autophagy. The autophagy process occurs in multiple stages through the coordinated action of autophagy-related genes. This review summarizes the evidence that autophagy is an integral component of reproduction. Additionally, we discuss emerging in vitro techniques that will enable cellular and molecular studies of autophagy and its associated pathways in reproduction. Finally, we discuss the role of autophagy in the pathogenesis and progression of several pregnancy-related disorders such as preterm birth, preeclampsia, and intra-uterine growth restriction, and its potential as a therapeutic target.

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自噬在生殖和妊娠相关疾病中的作用

虽然有性生殖在后代产生过程中具有优势，但它也是一种昂贵而危险的生殖策略。胎生真核生物在妊娠前、妊娠中和妊娠后都在进化以应对压力。自噬是控制代谢应激的一个重要而保守的细胞内途径。自噬过程通过自噬相关基因的协调作用分多个阶段进行。本综述总结了自噬是生殖不可或缺的组成部分的证据。此外，我们还讨论了新出现的体外技术，这些技术将有助于对自噬及其在生殖过程中的相关途径进行细胞和分子研究。最后，我们讨论了自噬在早产、子痫前期和宫内生长受限等几种妊娠相关疾病的发病机制和进展中的作用，以及自噬作为治疗靶点的潜力。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

iScience Multidisciplinary-Multidisciplinary

CiteScore

7.20

自引率

1.70%

发文量

1972

审稿时长

6 weeks

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