Exploring the molecular mechanisms and therapeutic benefits of L-theanine in counteracting inflammation

Abstract

Chronic inflammation, a persistent condition that can significantly impact the body, is linked to the development and progression of numerous chronic degenerative diseases. Understanding its complex role is essential for discovering innovative therapeutic approaches, particularly those derived from natural sources. These strategies aim to reduce chronic inflammation and mitigate its associated diseases. Historically, natural products have been used for their therapeutic properties, including anti-inflammatory effects. They often offer advantages such as abundant availability, cost-effectiveness, and fewer side effects compared to synthetic drugs. L-theanine, an amino acid primarily found in tea leaves, has garnered significant attention for its potential health benefits, especially its anti-inflammatory properties. Research suggests that L-theanine may decrease levels of inflammatory markers in the body and modulate the immune system, preventing excessive inflammatory responses. While the growing evidence supports L-theanine's ability to attenuate harmful inflammation, the exact molecular mechanisms underlying its action remain largely unknown. This review seeks to elucidate these mechanisms, providing a comprehensive understanding of its role in modulating inflammation and its potential as a natural therapeutic agent.