The prospect of electroceutical intervention and its implementation toward intractable neuromuscular diseases

IF 4.7 3区工程技术 Q2 ENGINEERING, BIOMEDICAL Current Opinion in Biomedical Engineering Pub Date : 2024-10-19 DOI:10.1016/j.cobme.2024.100563

Aseer Intisar , Minseok S. Kim

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Abstract

The treatment of intractable neuromuscular diseases (INMDs) via biochemical interventions has remained challenging. Treatments using electrical stimulation (ES), or electroceuticals, can potentially shift the paradigm in the treatment of INMDs, since (1) their localized nature minimizes the risks for systemic side effects and (2) they conform with the innate neuromuscular communication. In addition, the recent developments in electrical interfaces for the neuromuscular system can advance the possibility of the clinical adoption of electroceuticals. In this review, we first introduce the studies that have explored the potential of ES in the treatment or management of INMDs. We then highlight the recent advancements in interfaces to deliver ES to the neuromuscular system, focusing on their miniaturization, flexibility, and non-invasive implantation. This review sheds light on the therapeutic benefits and implementation of electroceuticals toward INMDs and will hopefully encourage further in-depth research that can transform their treatment landscape.

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电疗干预的前景及其在难治性神经肌肉疾病中的应用

通过生化干预治疗难治性神经肌肉疾病（INMDs）仍然具有挑战性。使用电刺激（ES）或电药物进行治疗有可能改变治疗 INMDs 的模式，因为（1）电刺激的局部性将全身副作用的风险降至最低，（2）电刺激符合神经肌肉的先天交流。此外，神经肌肉系统电接口的最新发展也为电疗法的临床应用提供了可能。在本综述中，我们首先介绍了探索 ES 在治疗或管理 INMDs 方面潜力的研究。然后，我们着重介绍了将 ES 输送到神经肌肉系统的接口的最新进展，重点关注其微型化、灵活性和无创植入。这篇综述揭示了电疗法对 INMDs 的治疗益处和实施情况，希望能鼓励进一步的深入研究，从而改变其治疗格局。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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