{"title":"Exploration of silk-hyaluronic acid hydrogels crosslinked by the Fenton reaction","authors":"Yeong Won Park, Dong Yun Lee, Jaewon Choi","doi":"10.1016/j.matlet.2024.137682","DOIUrl":null,"url":null,"abstract":"<div><div>Herein, HRP-free silk-HA hybrid hydrogels are generated using the Fenton reaction. The findings reveal that a higher HA concentration, at an appropriate crosslinking density, increases the random coil content while decreasing the <em>β</em>-sheet content by reducing the interactions of Fe<sup>3+</sup> ions with silk fibroin. This facilitates the formation of homogeneous hydrogel networks with enhanced optical transparency. The crosslinking strategies presented here offer a basis for the fabrication of hybrid hydrogel scaffolds based on proteins or polymers having phenolic hydroxyl moieties, without the use of HRP-catalyzed reactions, for a broad range of biomedical applications.</div></div>","PeriodicalId":384,"journal":{"name":"Materials Letters","volume":"379 ","pages":"Article 137682"},"PeriodicalIF":2.7000,"publicationDate":"2024-11-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Materials Letters","FirstCategoryId":"88","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S0167577X24018226","RegionNum":4,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"MATERIALS SCIENCE, MULTIDISCIPLINARY","Score":null,"Total":0}
引用次数: 0
Abstract
Herein, HRP-free silk-HA hybrid hydrogels are generated using the Fenton reaction. The findings reveal that a higher HA concentration, at an appropriate crosslinking density, increases the random coil content while decreasing the β-sheet content by reducing the interactions of Fe3+ ions with silk fibroin. This facilitates the formation of homogeneous hydrogel networks with enhanced optical transparency. The crosslinking strategies presented here offer a basis for the fabrication of hybrid hydrogel scaffolds based on proteins or polymers having phenolic hydroxyl moieties, without the use of HRP-catalyzed reactions, for a broad range of biomedical applications.
期刊介绍：
Materials Letters has an open access mirror journal Materials Letters: X, sharing the same aims and scope, editorial team, submission system and rigorous peer review.
Materials Letters is dedicated to publishing novel, cutting edge reports of broad interest to the materials community. The journal provides a forum for materials scientists and engineers, physicists, and chemists to rapidly communicate on the most important topics in the field of materials.
Contributions include, but are not limited to, a variety of topics such as:
• Materials - Metals and alloys, amorphous solids, ceramics, composites, polymers, semiconductors
• Applications - Structural, opto-electronic, magnetic, medical, MEMS, sensors, smart
• Characterization - Analytical, microscopy, scanning probes, nanoscopic, optical, electrical, magnetic, acoustic, spectroscopic, diffraction
• Novel Materials - Micro and nanostructures (nanowires, nanotubes, nanoparticles), nanocomposites, thin films, superlattices, quantum dots.
• Processing - Crystal growth, thin film processing, sol-gel processing, mechanical processing, assembly, nanocrystalline processing.
• Properties - Mechanical, magnetic, optical, electrical, ferroelectric, thermal, interfacial, transport, thermodynamic
• Synthesis - Quenching, solid state, solidification, solution synthesis, vapor deposition, high pressure, explosive
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