Multifunctional hydrogels loaded with tellurium nanozyme for spinal cord injury repair

IF 8.7 1区医学 Q1 ENGINEERING, BIOMEDICAL Materials Today Bio Pub Date : 2024-11-12 DOI:10.1016/j.mtbio.2024.101339

Jian Meng , Jingjing Sun , Jiali Kang , Shilei Ren , Miaomiao Xu , Runzhi Li , Xuhui Zhao , Yitong Yuan , Lei Xin , Ruiping Zhang

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Abstract

Spinal cord injury (SCI) results in severe neurological deficits due to disrupted neural pathways. While the spinal cord possesses limited self-repair capabilities, recent advancements in hydrogel-based therapies have shown promise. Polyphenol-based hydrogels, known for their neuroprotective properties, offer a suitable microenvironment for neural regeneration. In this study, a novel poly(lipoic acid)/poly(dopamine) adhesive hydrogel was developed as a versatile platform for delivering therapeutic agents. This hydrogel was loaded with methylcobalamin, a neurotrophic factor, and tellurium nanoenzymes, potent antioxidants. The nanoenzymes effectively mitigated oxidative stress and inflammation, while methylcobalamin promoted nerve regeneration. The combined therapeutic effects of the nanoenzymatic hydrogel demonstrated significant efficacy in repairing spinal cord injuries, highlighting its potential as a promising strategy for treating this debilitating condition.

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用于脊髓损伤修复的负载碲纳米酶的多功能水凝胶

脊髓损伤（SCI）会导致神经通路中断，造成严重的神经功能缺损。虽然脊髓的自我修复能力有限，但基于水凝胶的疗法的最新进展已显示出前景。以多酚为基础的水凝胶因其神经保护特性而闻名，为神经再生提供了合适的微环境。本研究开发了一种新型聚（硫辛酸）/聚（多巴胺）粘合水凝胶，作为输送治疗药物的多功能平台。这种水凝胶含有神经营养因子甲基钴胺素和强效抗氧化剂碲纳米酶。纳米酶有效缓解了氧化应激和炎症，而甲基钴胺素则促进了神经再生。纳米酶水凝胶的综合治疗效果在修复脊髓损伤方面显示出显著疗效，突显了其作为治疗这种衰弱病症的一种有前途的策略的潜力。

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来源期刊

Materials Today Bio Multiple-

CiteScore

8.30

自引率

4.90%

发文量

303

审稿时长

30 days

期刊介绍： Materials Today Bio is a multidisciplinary journal that specializes in the intersection between biology and materials science, chemistry, physics, engineering, and medicine. It covers various aspects such as the design and assembly of new structures, their interaction with biological systems, functionalization, bioimaging, therapies, and diagnostics in healthcare. The journal aims to showcase the most significant advancements and discoveries in this field. As part of the Materials Today family, Materials Today Bio provides rigorous peer review, quick decision-making, and high visibility for authors. It is indexed in Scopus, PubMed Central, Emerging Sources, Citation Index (ESCI), and Directory of Open Access Journals (DOAJ).