Materials Today Bio最新文献

Nanomaterial-enabled rheumatoid arthritis treatment: An advanced investigation into photonic - acoustic - gaseous multimodal therapy 纳米材料支持的类风湿关节炎治疗：光子-声学-气体多模态治疗的最新研究

IF 10.2 1区医学 Q1 ENGINEERING, BIOMEDICAL

Materials Today Bio

Pub Date : 2026-04-01 Epub Date: 2026-01-06 DOI: 10.1016/j.mtbio.2026.102772

Yuxin Chen, Yasi Deng, Bin Li, Yupei Yang, Hanwen Yuan, Huihong Duan, Wei Wang, Huanghe Yu

Rheumatoid arthritis (RA) is a chronic systemic autoimmune disease. Current treatments mainly involve drugs and surgery, but face limitations like adverse effects, invasive complications, and poor outcomes. Emerging nanomaterial-mediated modalities, particularly photothermal therapy (PTT), photodynamic therapy (PDT), photoacoustic (PA) imaging, sonodynamic therapy (SDT), and gas therapy, have demonstrated the potential to address these limitations. PTT leverages near-infrared (NIR)-responsive nanomaterials to induce localised hyperthermia, triggering apoptosis in pathogenic synovial tissues. PDT relies on photoactivated nanophotosensitizers to precisely eliminate hyperplastic synovium through spatiotemporally controlled reactive oxygen species (ROS) production. PA imaging uses NIR light to excite nanoparticles, generating ultrasound signals that are reconstructed into images, enabling real-time monitoring and assessment of RA joints. SDT employs ultrasound-activated nanosensitizers to produce cytotoxic ROS for the targeted ablation of inflammatory cells. Complementing these approaches, gas therapy, mediated by hydrogen-releasing nanomaterials, exerts immunomodulatory effects by scavenging ROS and regulating the inflammatory microenvironment. This review examines cutting-edge nanotherapeutic strategies that integrate photonic, acoustic, and gaseous modalities for RA management. Through an analysis of innovative nanosystem designs and their therapeutic mechanisms, this review highlights the emerging paradigm of synergistic multimodality approaches, which improve efficacy while reducing systemic adverse effects. This review will provide novel perspectives for advancing next-generation multimodal precision therapies for autoimmune diseases.

类风湿性关节炎（RA）是一种慢性全身自身免疫性疾病。目前的治疗主要包括药物和手术，但存在副作用、侵入性并发症和预后差等局限性。新兴的纳米材料介导的治疗方式，特别是光热治疗（PTT）、光动力治疗（PDT）、光声成像（PA）、声动力治疗（SDT）和气体治疗，已经证明了解决这些限制的潜力。PTT利用近红外（NIR）响应纳米材料诱导局部热疗，触发致病性滑膜组织的细胞凋亡。PDT依靠光激活的纳米光敏剂通过时空控制活性氧（ROS）的产生来精确消除滑膜增生。PA成像使用近红外光激发纳米粒子，产生超声信号，并将其重建为图像，从而实现对RA关节的实时监测和评估。SDT采用超声激活的纳米增敏剂产生细胞毒性ROS，靶向消融炎症细胞。与这些方法互补的是，由氢释放纳米材料介导的气体疗法，通过清除ROS和调节炎症微环境来发挥免疫调节作用。本文综述了整合光子、声学和气体模式的尖端纳米治疗策略。通过对创新纳米系统设计及其治疗机制的分析，本综述强调了协同多模态方法的新兴范例，这些方法在提高疗效的同时减少了全身不良反应。这一综述将为推进下一代自身免疫性疾病的多模式精确治疗提供新的视角。

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引用次数: 0

Fiber-integrated hydrogels: a versatile platform to improve structural and biological performance in 3D biofabrication 纤维集成水凝胶：一个多功能平台，以提高结构和生物性能的3D生物制造

IF 10.2 1区医学 Q1 ENGINEERING, BIOMEDICAL

Materials Today Bio

Pub Date : 2026-04-01 Epub Date: 2026-01-19 DOI: 10.1016/j.mtbio.2026.102799

Annabelle Neuhäusler , Nils Lindner , Andreas Blaeser

Hydrogels emerged as versatile biomaterials for tissue engineering due to their extra cellular matrix similarity and mechanical and biochemical properties. Still, hydrogels expose limited stiffness, anisotropy and nutrient diffusion. By reinforcing hydrogels with synthetic and natural fibers, these drawbacks can be effectively addressed, thereby enabling the modeling of advanced biomimetic tissue. This review discusses recent progress in the fabrication of fiber-integrated hydrogels and brings together developments from biomaterials, biofabrication, mechanobiology, and organ-model engineering. Fiber-addition impact on viscoelastic, time-dependent und nonlinear material properties, on multiscale and hierarchical constructs and on mechanical and biological readouts are analyzed. Specifically, the integration of both synthetic and natural fibers into hydrogel matrices is highlighted which significantly broaden their structural and biochemical versatility. These fiber-added hydrogels display improved properties including enhanced stiffness (up to 10-fold increase), anisotropy (>80 % alignment) and nutrient diffusion (4-fold increase). Moreover, the incorporation of fibers directly impacts cellular behavior by promoting adhesion, migration, proliferation and differentiation. Finally, bone, muscle and nerve tissue are exemplary presented in more detail to highlight the broad potential of these composite materials. In conclusion, fiber-embedded hydrogels represent a decisive step toward enhanced 4D-metamaterials.

水凝胶由于其细胞外基质的相似性以及机械和生化特性而成为组织工程中通用的生物材料。尽管如此，水凝胶暴露出有限的刚度、各向异性和营养扩散。通过用合成纤维和天然纤维增强水凝胶，可以有效地解决这些缺点，从而使先进的仿生组织建模成为可能。本文综述了纤维集成水凝胶制备的最新进展，并从生物材料、生物制造、机械生物学和器官模型工程等方面进行了综述。分析了纤维添加对粘弹性、时变和非线性材料性能、多尺度和分层结构以及力学和生物读数的影响。具体来说，合成纤维和天然纤维在水凝胶基质中的整合被强调，这大大拓宽了它们的结构和生化通用性。这些添加纤维的水凝胶显示出改善的性能，包括增强的刚度（增加10倍），各向异性（>； 80%对齐）和营养扩散（增加4倍）。此外，纤维的掺入通过促进粘附、迁移、增殖和分化直接影响细胞行为。最后，以骨、肌肉和神经组织为例，更详细地介绍了这些复合材料的广泛潜力。总之，纤维嵌入的水凝胶代表了增强4d超材料的决定性一步。

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引用次数: 0

Copper-based nanozymes synergistically enhance Cuproptosis for psoriasis treatment 铜基纳米酶对银屑病治疗有协同作用

IF 10.2 1区医学 Q1 ENGINEERING, BIOMEDICAL

Materials Today Bio

Pub Date : 2026-04-01 Epub Date: 2026-01-29 DOI: 10.1016/j.mtbio.2026.102855

Junyu Zhou , Nianzhou Yu , Xiaoxin Yang , Shanghong Li , Mi Huang , Tianyi Pang , Dong Zhong , Yu Wen , Hong Liu

Psoriasis is a chronic inflammatory skin disease characterized by abnormal keratinocyte proliferation and sustained skin inflammation. Cuproptosis, a novel regulated cell death pathway, inhibits proliferation by promoting cellular demise, offering a promising therapeutic strategy for psoriasis. Herein, we first identified that cuproptosis induction is a potential therapeutic avenue for psoriasis treatment. Then, a copper-based nanozyme (Cu-NZ) was developed to enhance cuproptosis through cascade catalytic therapy, leveraging multi-enzymatic effects for psoriasis treatment. The Cu-NZs exhibited distinct multi-enzymatic activities, including catalase (CAT)-, superoxide dismutase (SOD)-, oxidase (OXD)-, and peroxidase (POD)-like activities, which sustained the generation of cytotoxic Reactive Oxygen Species (ROS), relieved hypoxia via O₂ release, and ultimately triggered augmented cuproptosis. In vitro results demonstrated that Cu-NZs suppressed HaCaT cells proliferation and inflammatory factor expression while inducing mitochondrial dysfunction through ROS elevation. Mechanistically, Cu-NZs modulated the expression of cuproptosis-related genes and proteins (DLAT, FDX1, LIAS). In vivo studies confirmed that topical Cu-NZs gel significantly alleviated imiquimod (IMQ)-induced psoriatic phenotypes in mice without inducing systemic organ toxicity. Collectively, Cu-NZs mitigated psoriasis manifestations by triggering cuproptosis in keratinocytes, thereby inhibiting their pathological activation and proliferation. These findings provided a theoretical foundation for the clinical translation of Cu-NZs-based therapies.

银屑病是一种慢性炎症性皮肤病，其特征是角质细胞异常增殖和持续的皮肤炎症。cuprotosis是一种新的调节细胞死亡途径，通过促进细胞死亡来抑制增殖，为银屑病的治疗提供了一种有希望的治疗策略。在此，我们首先确定了铜变诱导是治疗牛皮癣的潜在治疗途径。然后，开发了一种铜基纳米酶（Cu-NZ），通过级联催化疗法增强铜降解，利用多酶效应治疗银屑病。Cu-NZs表现出明显的多酶活性，包括过氧化氢酶(CAT)-、超氧化物歧化酶(SOD)-、氧化酶(OXD)-和过氧化物酶（POD）样活性，这些活性维持细胞毒性活性氧（ROS）的产生，通过释放O2缓解缺氧，最终引发铜还原增强。体外实验结果表明Cu-NZs抑制HaCaT细胞增殖和炎症因子表达，同时通过ROS升高诱导线粒体功能障碍。从机制上讲，Cu-NZs调节铜质增生相关基因和蛋白（DLAT, FDX1， LIAS）的表达。体内研究证实，局部Cu-NZs凝胶可显著减轻咪喹莫特（IMQ）诱导的小鼠银屑病表型，而不会引起全身器官毒性。总的来说，Cu-NZs通过触发角化细胞中的铜沉积，从而抑制其病理活化和增殖，从而减轻银屑病的表现。这些发现为cu - nzs为基础的治疗方法的临床转化提供了理论基础。

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引用次数: 0

Atomically preserved MXene quantum dots as a redox-responsive nanoplatform for light-controlled bidirectional ROS engineering 原子保存MXene量子点作为光控双向ROS工程的氧化还原响应纳米平台。

IF 10.2 1区医学 Q1 ENGINEERING, BIOMEDICAL

Materials Today Bio

Pub Date : 2026-04-01 Epub Date: 2026-01-28 DOI: 10.1016/j.mtbio.2026.102864

Dejia Hu , Tianhao Xia , Danyang Xiao , Bufeng Liang , Yuyi Li , Jinkun Li , Zhongliao Zeng , Jianxiong Ma , Yan Li

MXene quantum dots (MQDs) combine the intrinsic reductive properties of MXenes with the photoactivity induced by quantum confinement, positioning them as promising agents for dynamic redox regulation in therapeutic applications. However, their translation into practice has been limited by persistent synthetic issues, including transition-metal leaching and oxidative degradation. To address these challenges, a sodium ascorbate-mediated coordination and reduction strategy was developed for hydrothermal synthesis of structurally intact Ti₂C MQDs with improved crystallinity and high titanium retention. The resulting MQDs exhibit a unique extension of optical absorption into the visible range, which facilitates efficient ROS generation under visible-light irradiation and confers potent antibacterial properties against pathogenic bacteria. Concurrently, the MQDs demonstrate broad-spectrum ROS scavenging ability. At the cellular level, they effectively reduced oxidative stress and inflammation while promoting M2 macrophage polarization. Capitalizing on these dual redox activities and excellent biocompatibility, a collagen–alginate microneedle patch (MQDs@Col-SA MN) was designed to evaluate their therapeutic potential. In a diabetic wound model, this system achieved ∼80 % smaller wound area than untreated controls at Day 10, while also outperforming a positive control dressing. This study represents the first report of structurally preserved MQDs capable of adaptive redox regulation, underscoring their utility as a versatile platform for microenvironment modulation and regenerative medicine.

MXene量子点（MQDs）结合了MXene的固有还原特性和量子约束诱导的光活性，使其成为有前途的治疗应用的动态氧化还原调控剂。然而，它们转化为实践受到持续合成问题的限制，包括过渡金属浸出和氧化降解。为了解决这些挑战，研究人员开发了一种抗坏血酸钠介导的配位和还原策略，用于水热合成结构完整的Ti2C mqd，具有更好的结晶度和高钛保留率。由此产生的mqd具有独特的光吸收延伸到可见光范围，这有助于在可见光照射下高效生成ROS，并具有对致病菌的有效抗菌性能。同时，mqd显示出广谱ROS清除能力。在细胞水平上，它们有效地减少氧化应激和炎症，同时促进M2巨噬细胞极化。利用这些双重氧化还原活性和良好的生物相容性，设计了胶原-海藻酸盐微针贴片（MQDs@Col-SA MN）来评估其治疗潜力。在糖尿病伤口模型中，该系统在第10天的伤口面积比未治疗的对照组小约80 %，同时也优于阳性对照敷料。这项研究首次报道了结构上保存的mqd能够进行适应性氧化还原调节，强调了它们作为微环境调节和再生医学的通用平台的实用性。

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引用次数: 0

Orchestrating the immuno-chondrogenic microenvironment via a bio-inorganic hybrid microsphere system for tendon-to-bone healing 通过生物-无机混合微球系统协调肌腱-骨愈合的免疫-软骨微环境。

IF 10.2 1区医学 Q1 ENGINEERING, BIOMEDICAL

Materials Today Bio

Pub Date : 2026-04-01 Epub Date: 2026-01-27 DOI: 10.1016/j.mtbio.2026.102851

Wencai Liu , Yuhao Yu , Hui Xu , Weiming Lin, Xin Wang, Yiming Li, Xiping Jiang, Chenrui Yuan, Yifei Wang, Xinyue Yang, Di Wu, Lingzhi Kong, Weilin Yu, Wei Song, Yaohua He

The structural failure of rotator cuff repair is largely attributed to fibrovascular scar formation driven by a persistent inflammatory microenvironment and insufficient fibrocartilage regeneration at the tendon-to-bone interface. To address this, a microfluidic-generated GelMA microsphere system co-encapsulating Zeolitic Imidazolate Framework-8 (ZIF-8) nanoparticles and bone marrow mesenchymal stem cell (BMSC)-derived small extracellular vesicles (sEVs) is developed. This composite system (ZIF-8/sEVs@MS) enables the sustained release of Zn²⁺ and sEVs, which synergistically reprogram macrophages (Mφ) from a pro-inflammatory M1 phenotype to a reparative M2 state and restore the CXCL12/CXCR4 axis for endogenous stem cell recruitment. Transcriptomic analysis elucidates that the system reactivates the PI3K/AKT signaling pathway, thereby reversing inflammation-mediated inhibition and driving chondrogenic differentiation. In a rat rotator cuff repair model, the functionalized microspheres significantly enhance fibrocartilaginous enthesis regeneration, biomechanical structural integrity, and limb function. This study establishes a dual-functional “immuno-chondrogenic” strategy that coordinates immune microenvironment modulation with tissue-specific differentiation to facilitate functional tendon-to-bone healing.

肌腱袖修复的结构失败主要是由于持续的炎症微环境和肌腱-骨界面纤维软骨再生不足导致的纤维血管瘢痕形成。为了解决这个问题，研究人员开发了一种微流体生成的凝胶微球系统，该系统将沸石咪唑酸框架-8 （ZIF-8）纳米颗粒和骨髓间充质干细胞（BMSC）衍生的小细胞外囊泡（sev）共封装。这种复合系统（ZIF-8/sEVs@MS）能够持续释放Zn2+和sev，它们协同重编程巨噬细胞（Mφ），使其从促炎M1表型转变为修复性M2状态，并恢复CXCL12/CXCR4轴，以促进内源性干细胞募集。转录组学分析表明，该系统重新激活PI3K/AKT信号通路，从而逆转炎症介导的抑制并驱动软骨分化。在大鼠肩袖修复模型中，功能化微球显著增强纤维软骨内腔再生、生物力学结构完整性和肢体功能。本研究建立了一种双功能的“免疫-软骨”策略，协调免疫微环境调节和组织特异性分化，促进功能性肌腱到骨愈合。

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引用次数: 0

Research progress of blood-brain barrier penetrating and brain diseases therapy by natural biopolymer - based nanomedicine delivery systems 基于天然生物聚合物的纳米药物输送系统穿透血脑屏障及治疗脑病的研究进展

IF 10.2 1区医学 Q1 ENGINEERING, BIOMEDICAL

Materials Today Bio

Pub Date : 2026-04-01 Epub Date: 2026-01-25 DOI: 10.1016/j.mtbio.2026.102849

Lijing Qin , Xiu Wang , Tongjuan Liang , Yongyi Bi , Zhijun Guo , Wenzhong Li , Wanjun Liang

Brain diseases are one of the most critical threats to human health. The blood-brain barrier (BBB) prevents drugs from entering the brain, rendering standard treatments for neurological illnesses ineffective. In recent years, there has been an increase in interest in nanotechnology-based research to develop innovative drug delivery systems (NDDS) for drug loading, BBB penetration, and precision delivery to diseased areas. Nanocarriers made from natural biomaterials, in particular, solve the drawbacks of standard nanocarriers, such as low stability and inadequate targeting, while simultaneously providing benefits such as simplicity of modification and good biodegradability. This review focuses on the most recent advances in NDDS based on natural biomaterials for overcoming the BBB in treating brain diseases, with a particular emphasis on the methods and mechanisms by which natural biopolymers—such as polysaccharides, peptides, and polynucleotides—break through the BBB and enhance brain-targeted delivery. We explore current challenges and future application prospects of natural biopolymers in permeable nanomedicine delivery systems for the BBB, aiming to provide key insights for advancing cross-BBB delivery platforms toward smarter, multifunctional development, subsequent research, and translational applications.

脑部疾病是对人类健康最严重的威胁之一。血脑屏障（BBB）阻止药物进入大脑，使得神经系统疾病的标准治疗无效。近年来，人们对基于纳米技术的研究越来越感兴趣，以开发创新的药物递送系统（NDDS），用于药物装载，血脑屏障渗透和精确递送到患病区域。特别是由天然生物材料制成的纳米载体，解决了标准纳米载体稳定性低、靶向性不足等缺点，同时具有修饰简单、生物降解性好等优点。本文综述了基于天然生物材料的抗脑屏障药物治疗脑疾病的最新进展，重点介绍了天然生物聚合物（如多糖、多肽和多核苷酸）突破脑屏障并增强脑靶向递送的方法和机制。我们探讨了天然生物聚合物在血脑屏障可渗透纳米药物递送系统中的当前挑战和未来应用前景，旨在为推动跨血脑屏障递送平台朝着更智能、多功能的发展、后续研究和转化应用提供关键见解。

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引用次数: 0

Alendronic acid modified PLGA drug delivery system loaded with 17β-Estradiol and vitamin D3 has anti-osteoporotic effect 阿仑膦酸修饰PLGA载17β-雌二醇和维生素D3给药系统具有抗骨质疏松作用

IF 10.2 1区医学 Q1 ENGINEERING, BIOMEDICAL

Materials Today Bio

Pub Date : 2026-04-01 Epub Date: 2026-01-12 DOI: 10.1016/j.mtbio.2026.102789

Yonghui Wang , Sidi Zhang , Xinrun Ma , Donghao Hu , Junran Liu , Lu Wei , Xue Lei , Yan Hu , Fuyou Li , Yanhong Gao

Postmenopausal osteoporosis caused by estrogen deficiency often requires hormone replacement therapy (HRT), but its systemic side effects limit clinical application. Here, we developed a bone-targeted Poly (lactic-co-glycolic acid) (PLGA) nanocarrier modified with Alendronic acid (ADA) to co-deliver 17β-Estradiol (E2) and Vitamin D3 (VitD3), aiming to enhance efficacy and safety. The ADA-functionalized nanoparticles (E2+VD@PLGA_IR780ADA) showed high drug loading (7.2 wt% for E2 and 2.3 wt% for VitD3), sustained release (>90 % over 48 h). In ovariectomized (OVX) mice, targeted delivery significantly improved bone mineral density, restored trabecular structure, and reduced serum bone resorption markers, while markedly alleviating E2-induced endometrial thickening. In vivo imaging confirmed selective bone accumulation. Mechanistically, co-administration of VitD3 and E2 elicits enhanced pro-osteogenic effects by virtue of VitD3-mediated Vitamin D Receptor (VDR) upregulation and amplified E2-induced estrogen receptor (ER) expression, which collectively drive robust activation of the PI3K/AKT/mTOR signaling cascade.This bone-specific nanoplatform offers a promising and safer strategy for osteoporosis therapy beyond conventional HRT.

雌激素缺乏引起的绝经后骨质疏松症通常需要激素替代治疗（HRT），但其全身副作用限制了临床应用。本研究以阿仑膦酸（ADA）修饰的聚乳酸-羟基乙酸（PLGA）为骨靶向纳米载体，共同递送17β-雌二醇（E2）和维生素D3 (VitD3)，旨在提高其疗效和安全性。ada功能化纳米颗粒（E2+VD@PLGAIR780ADA）显示出高载药量（E2为7.2 wt%， VitD3为2.3 wt%），缓释（48小时内缓释90%）。在卵巢切除（OVX）小鼠中，靶向递送显著改善骨密度，恢复小梁结构，降低血清骨吸收标志物，同时显著减轻e2诱导的子宫内膜增厚。体内成像证实选择性骨积聚。从机制上讲，通过VitD3介导的维生素D受体（VDR）上调和E2诱导的雌激素受体（ER）表达扩增，VitD3和E2联合使用可增强促成骨作用，从而共同驱动PI3K/AKT/mTOR信号级联的强大激活。这种骨特异性纳米平台为骨质疏松症治疗提供了一种比传统激素替代疗法更有前途和更安全的策略。

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引用次数: 0

Dual-responsive PDA-HP hydrogel enables mitochondria-targeted mild photothermal therapy for spinal cord repair 双响应PDA-HP水凝胶使线粒体靶向轻度光热治疗脊髓修复

IF 10.2 1区医学 Q1 ENGINEERING, BIOMEDICAL

Materials Today Bio

Pub Date : 2026-04-01 Epub Date: 2026-01-14 DOI: 10.1016/j.mtbio.2026.102783

Yi Li , Jiaxuan Hu , Bing Ran , Huisheng Zhong , Nayin Zhong , Yi Zhong , Xinyu Fu , Xinying Liu , Guanghua Wu , Qinwen Zhong , Juan Li

Spinal cord injury (SCI) is a devastating neurological disorder with substantial economic and psychological burdens, underscoring the urgent need for effective therapeutic strategies. Here, we developed a dual-responsive hydrogel composed of polydopamine (PDA) and heparin-poloxamer (HP) that enables controllable mild photothermal stimulation under near-infrared (NIR) irradiation. The PDA-HP hydrogel exhibited excellent biocompatibility, biodegradability, and stable photothermal conversion. In a mouse SCI model, in situ administration of PDA-HP combined with NIR irradiation markedly improved locomotor recovery and mitigated tissue damage. Mechanistically, PDA-HP/NIR therapy reduced oxidative stress, preserved mitochondrial structure, restored ATP production, and—most notably—normalized the maladaptive overexpression of heat-shock protein 70 (HSP70) induced by SCI, thereby decreasing apoptosis and promoting neuronal survival. Quantitative proteomics further identified stress-chaperone and mitochondrial pathways as major targets of this intervention. To our knowledge, this is the first study demonstrating that PDA-HP-mediated mild photothermal modulation restores mitochondrial function through HSP70 normalization in SCI. These findings highlight a mitochondria-targeted mild photothermal strategy as a promising and clinically translatable approach for spinal cord repair.

脊髓损伤（SCI）是一种毁灭性的神经系统疾病，具有巨大的经济和心理负担，迫切需要有效的治疗策略。在这里，我们开发了一种由聚多巴胺（PDA）和肝素-波洛沙姆（HP）组成的双响应水凝胶，可以在近红外（NIR）照射下实现可控的轻度光热刺激。PDA-HP水凝胶具有良好的生物相容性、生物降解性和稳定的光热转化。在小鼠脊髓损伤模型中，原位给药PDA-HP联合近红外照射可显著改善运动恢复并减轻组织损伤。在机制上，PDA-HP/NIR治疗可减少氧化应激，保存线粒体结构，恢复ATP的产生，最值得注意的是，可使脊髓损伤引起的热休克蛋白70 （HSP70）的过度表达正常化，从而减少细胞凋亡，促进神经元存活。定量蛋白质组学进一步确定了应激伴侣和线粒体途径是这种干预的主要目标。据我们所知，这是第一个研究表明，在脊髓损伤中，pda - hp介导的轻度光热调节通过HSP70正常化恢复线粒体功能。这些发现强调了线粒体靶向的轻度光热策略作为脊髓修复的一种有前途和临床可翻译的方法。

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引用次数: 0

Escape from cell uptake: Drug-Free cancer therapeutics regulated by hydrophobicity and negative charge 逃避细胞摄取：由疏水性和负电荷调节的无药物癌症治疗

IF 10.2 1区医学 Q1 ENGINEERING, BIOMEDICAL

Materials Today Bio

Pub Date : 2026-04-01 Epub Date: 2025-12-30 DOI: 10.1016/j.mtbio.2025.102752

Kazuki Moroishi , Masahiko Nakamoto , Satoshi Fujita , Marie Kawahara , Ryohei Katayama , Michiya Matsusaki

Self-aggregation and inducing cell membrane disruption in response to tumor microenvironment-stimuli is expected to be a promising approach for cancer treatment, but is limited by its insufficient stimuli-responsive cytotoxicity due to a lack of in-depth understanding of molecular characteristics, resulting in low selectivity of cell death induction. In this study, we focused on engineering polymer aggregation in detail to further improve tumor microenvironment-responsive cytotoxicity. PVA-U with grafting degrees (G.D.) of 3 % (PVA-U3), 15 % (PVA-U15), and 25 % (PVA-U25) were synthesized and their aggregation properties cytotoxicity was evaluated. The difference in half maximal inhibitory concentration (IC₅₀) values between pH 7.4 and pH 6.5 for PVA-U15 was 4.3-fold, which was greater than that of PVA-U25 at 2.8-fold, suggesting that tumor microenvironment-responsive cytotoxicity could be regulated by controlling G.D. of UDCA. Interestingly, PVA-U15 formed aggregates in the pericellular environment and adsorbed on the cell, effectively inducing cell death whereas PVA-U3 and PVA-U25 showed internalization in the cell. These results indicated that the balance of the surface charge and hydrophobicity could contribute to the adsorption on the cell membrane. These findings are expected to contribute to the development of membrane disruption strategies to control the aggregation properties and cell membrane interaction.

肿瘤微环境刺激下的自聚集诱导细胞膜破裂有望成为一种很有前景的癌症治疗方法，但由于缺乏对分子特性的深入了解，其刺激反应性细胞毒性不足，导致诱导细胞死亡的选择性低。在本研究中，我们将重点关注工程聚合物聚集，以进一步提高肿瘤微环境响应性细胞毒性。合成了接枝度分别为3% （PVA-U3）、15% （PVA-U15）和25% （PVA-U25）的PVA-U，并对其聚合性能进行了细胞毒性评价。在pH 7.4和pH 6.5之间，PVA-U15的半数最大抑制浓度（IC50）值相差4.3倍，大于PVA-U25的2.8倍，表明通过控制UDCA的G.D.可以调节肿瘤微环境反应性细胞毒性。有趣的是，PVA-U15在细胞周围环境中形成聚集体并吸附在细胞上，有效诱导细胞死亡，而PVA-U3和PVA-U25则在细胞内内化。这些结果表明，表面电荷和疏水性的平衡有助于在细胞膜上吸附。这些发现有望促进膜破坏策略的发展，以控制聚集特性和细胞膜相互作用。

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引用次数: 0

A novel dual-reactive primer enhances bond durability and builds chemical interlocking structures at the caries-affected dentin–biomaterial interface 一种新型的双反应引物增强了牙本质-生物材料界面的结合耐久性和化学连锁结构

IF 10.2 1区医学 Q1 ENGINEERING, BIOMEDICAL

Materials Today Bio

Pub Date : 2026-04-01 Epub Date: 2026-01-09 DOI: 10.1016/j.mtbio.2026.102793

Kai Tang , Rongchen Xu , Longyan Duan , Zhenyu Yang , Xinkai Cui , Wen Niu , Wei Zhou , Franklin R. Tay , Lina Niu , Fu Wang , Jihua Chen

Dental caries remains a major challenge in clinical dentistry, with successful resin restoration relying on the formation of a durable dentin–resin interface. In minimally invasive dentistry (MID), caries-affected dentin (CAD) is routinely preserved and often becomes the primary bonding substrate. However, bonding to CAD is suboptimal, and current strategies to improve this interface are limited. Here, we present a novel bonding strategy based on a dual-reactive functional monomer, ITCM, in combination with pretreatment application techniques. A simple 5-s ITCM pretreatment significantly enhanced both immediate and aged bond strength to CAD. Acting as a “molecular bridge”, ITCM bridges hydrophilic CAD layer with hydrophobic adhesive layer, facilitating the formation of a chemical interlocking structure, increasing CAD surface energy, and promoting deep adhesive infiltration. In addition, ITCM improves collagen enzymatic resistance and functions as a non-zinc-binding inhibitor of MMPs. Biocompatibility assessments demonstrated acceptable in vitro and in vivo safety, supporting its clinical potential. This study addresses a critical challenge in dentistry by introducing a chemical bonding strategy tailored to CAD. The ITCM pretreatment strategy provides a foundation for next-generation adhesives aimed at reinforcing the CAD–resin interface, extending restoration longevity, and preventing secondary caries.

龋齿仍然是临床牙科的主要挑战，成功的树脂修复依赖于持久的牙本质-树脂界面的形成。在微创牙科（MID）中，龋齿影响的牙本质（CAD）通常被保留，并经常成为主要的粘接基质。然而，与CAD的结合是次优的，并且目前改善该接口的策略是有限的。在这里，我们提出了一种基于双反应功能单体ITCM结合预处理应用技术的新型键合策略。简单的5-s ITCM预处理显著提高了与CAD的即时和时效结合强度。ITCM作为“分子桥”，将亲水CAD层与疏水粘接层架起桥梁，有利于形成化学联锁结构，增加CAD表面能，促进粘接剂深度渗透。此外，ITCM还能提高胶原的酶抗性，并作为MMPs的非锌结合抑制剂发挥作用。生物相容性评估显示出可接受的体外和体内安全性，支持其临床潜力。本研究通过引入针对CAD的化学键策略来解决牙科中的一个关键挑战。ITCM预处理策略为下一代粘合剂提供了基础，旨在增强cad -树脂界面，延长修复寿命，防止继发性龋齿。

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