Association between dental diseases and stroke

IF 1.7 Q3 DENTISTRY, ORAL SURGERY & MEDICINE Saudi Dental Journal Pub Date : 2024-11-01 DOI:10.1016/j.sdentj.2024.09.012

Haocheng Zhang , Qian Yu , Caidi Ying , Yibo Liu , Xiaoyu Wang , Yinghan Guo , Liang Xu , Yuanjian Fang , Xiaoyue Liao , Sheng Chen

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Abstract

Introduction

This study aimed to analyze the existing evidence on the association between dental diseases and stroke. Various pathogenic mechanisms, including bacteraemia and systemic inflammation, were investigated to explore their impact on stroke occurrence and severity.

Methods

A comprehensive literature search was conducted through the online databases PubMed, Google Scholar, Web of Science, and Scopus. The initial screening process resulted in a total of 138 articles being gathered. Upon subsequent refinement, 52 articles were discarded due to duplication or non-English language, leaving 86 articles for further assessment.

Results

Oral bacteria can travel to the brain’s blood vessels and cause bacteraemia, leading to local inflammation and the release of toxins. This process can result in the blockage or rupture of blood vessels, leading to stroke. Oral infections consistently trigger immune responses and systemic inflammation, with inflammation-related proteins playing a crucial role in stroke development. Notably, periodontal treatment could reduce the risk of stroke.

Conclusion

This review emphasizes the role of dental diseases in promoting stroke occurrence through various mechanisms. Dental diseases contribute to the development of stroke by facilitating bacteraemia and systemic inflammation. Furthermore, through effectively treating and preventing dental diseases, the risk of strokes can be significantly reduced.

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牙科疾病与中风之间的关系

引言本研究旨在分析牙科疾病与中风之间关系的现有证据。方法通过在线数据库 PubMed、Google Scholar、Web of Science 和 Scopus 进行了全面的文献检索。经过初步筛选，共收集到 138 篇文章。结果口腔细菌可进入脑血管并引起菌血症，导致局部炎症和毒素释放。这一过程可导致血管堵塞或破裂，从而引发中风。口腔感染会持续引发免疫反应和全身炎症，与炎症相关的蛋白质在中风的发生中起着至关重要的作用。本综述强调了牙科疾病通过各种机制促进中风发生的作用。牙科疾病通过促进菌血症和全身性炎症而导致中风的发生。此外，通过有效治疗和预防牙科疾病，可大大降低中风的风险。

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来源期刊

Saudi Dental Journal DENTISTRY, ORAL SURGERY & MEDICINE-

CiteScore

3.60

自引率

0.00%

发文量

审稿时长

22 weeks

期刊介绍： Saudi Dental Journal is an English language, peer-reviewed scholarly publication in the area of dentistry. Saudi Dental Journal publishes original research and reviews on, but not limited to: • dental disease • clinical trials • dental equipment • new and experimental techniques • epidemiology and oral health • restorative dentistry • periodontology • endodontology • prosthodontics • paediatric dentistry • orthodontics and dental education Saudi Dental Journal is the official publication of the Saudi Dental Society and is published by King Saud University in collaboration with Elsevier and is edited by an international group of eminent researchers.