Role of Granisetron in preventing hypotension after spinal anaesthesia with Levobupivacaine in rheumatic patients undergoing elective cesarean section: A randomized controlled trial

Abstract

Background

Heart disease, which carries a high risk, is the main factor contributing to maternal death and morbidity during pregnancy. In this trial, we examined how well intravenous (IV) granisetron prevented bradycardia and hypotension in rheumatic patients undergoing elective cesarean delivery.

Patients and methods

There were 102 patients total in the study, 51 in each of the two groups. Patients in Group G received 1 mg of IV granisetron diluted to 5 ml before the start of spinal anaesthesia, while those in Group S received 5 ml of 0.9 % normal saline. It has been recorded how much atropine and vasopressor were used overall. The Apgar scores at one and five minutes were also examined.

Results

In Group S, the prevalence of hypotension was 60.7 %, compared to 33.3 % in Group G (p < 0.05). As a result, patients in Group S needed considerably more ephedrine (p < 0.05). Patients in Group G had their hemodynamic parameters well maintained for the duration of the research. The Apgar score measured the neonatal outcome at 0-, 1-, and 5 min following birth, and it was equivalent between the two study groups.

Conclusion

Before spinal anaesthesia, intravenous granisetron 1 mg can lower hypotension in cardiac parturients without negatively affecting the mother or the baby.